Skin Structure and Function, Wound Healing and Scarring

Sullivan, Justine Victoria; Myers, Simon

doi:10.1016/b978-0-323-65381-7.00001-0

Cited by 6 publications

(9 citation statements)

References 29 publications

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Section: Resultsmentioning

confidence: 99%

“…As shown in Figure 12c, in the inflammation phase, macrophages as inflammatory cells and followed by neutrophils arrive at the wound. After that, in the proliferation phase, keratinocytes begin to proliferate and migrate toward the wound site, and activated fibroblasts by chemically attraction 54 . On the other hand, vimentin‐deficient inhibits fibroblast growth resulting in impaired keratinocyte activity, fibroblast‐deficient and as well as preventing in collagen accumulation.…”

Section: Resultsmentioning

confidence: 99%

“…The wound healing process includes different bimolecular phases, such as inflammation (clot formation, granulation tissue formation, cell attachment, and migration), proliferation (reepithelialization and angiogenesis), and maturation (collagen secretion and wound closure). 54 The degree of wound healing was determined by the H&E and collagen synthesis. As shown in Figure 12a, granulation tissue formation was observed for the A6P7 group at 5 days, while the granulation tissue was formed at 7 days for the A6 and control groups.…”

Section: Wound Healing Effect Of 3d Bioprinting Scaffolds In Skin Def...mentioning

confidence: 99%

“…After that, in the proliferation phase, keratinocytes begin to proliferate and migrate toward the wound site, and activated fibroblasts by chemically attraction. 54 On the other hand, vimentin-deficient inhibits fibroblast growth resulting in impaired keratinocyte activity, fibroblast-deficient and as well as preventing in collagen accumulation. In the other word, vimentin helps to accumulate collagen and activate keratinocytes by controlling the proliferation of fibroblasts, in which leads to wound healing.…”

Section: Wound Healing Effect Of 3d Bioprinting Scaffolds In Skin Def...mentioning

confidence: 99%

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Development of novel alginate‐polyethyleneimine cell‐laden bioink designed for 3D bioprinting of cutaneous wound healing scaffolds

Khoshnood

Zamanian

2022

J of Applied Polymer Sci

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In this work, the novel bioink composed of alginate and polyethyleneimine were prepared with different concentrations of alginate and polyethyleneimine (PEI) and used to measure printability, rheological behavior, and cellular functions. The results indicated that viscosity tends to increase about 1.3 times with increasing the alginate and PEI content, which gradually affected structural fidelity. The presence of PEI can create a bioink that is partially gelled with higher storage modulus, high shape fidelity, and printability than alginate. Increasing in the mechanical strength and decreasing in the swelling rate for alginate/PEI bioink demonstrated the strong effect of PEI on the enhancing of structure rigidity in the alginate‐based bioinks. Finally, the cell viability and cell proliferation of the 3D alginate/PEI scaffolds were examined using live/dead and 40,6‐diamidino‐2‐phenylindole staining to select the best bioink formulation. Fibroblast‐laden bioink of 6% alginate and 7% PEI indicated the high proliferation of the printed cells via increasing in hydrophilicity of the surface. The in‐vivo evaluations on the wound rat model indicated that the 3D scaffold effectively accelerated the wound healing process and promoted tissue regeneration by activation of vimentin along with cytokeratin as well as collagen synthesis. Hair follicles started to form at Day 7 in alginate/PEI scaffold.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Wound Healing Effect Of 3d Bioprinting Scaffolds In Skin Def...mentioning

confidence: 99%

Section: Wound Healing Effect Of 3d Bioprinting Scaffolds In Skin Def...mentioning

confidence: 99%

See 2 more Smart Citations

Development of novel alginate‐polyethyleneimine cell‐laden bioink designed for 3D bioprinting of cutaneous wound healing scaffolds

Khoshnood

Zamanian

2022

J of Applied Polymer Sci

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“…This critical structure endures mechanical damage, ultraviolent radiation, extreme temperatures and microbial presence to maintain the ideal conditions for the internal organs to function. 1 , 2 , 3 The importance of skin translates into a large cost associated with injury and healing. In the US alone, non-healing wounds, scarring, and burns present large problems for the patient and the medical system, accounting for $50, $12, and $7.5 billion respectively every year.…”

Section: Introductionmentioning

confidence: 99%

Angiopoietin-1 derived peptide hydrogel promotes molecular hallmarks of regeneration and wound healing in dermal fibroblasts

Vizely¹,

Wagner²,

Mandla³

et al. 2023

iScience

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Biomaterials for immunomodulation in wound healing

Wang,

Vizely,

et al. 2024

Regenerative Biomaterials

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The substantial economic impact of nonhealing wounds, scarring, and burns stemming from skin injuries is evident, resulting in a financial burden on both patients and the healthcare system. This review paper provides an overview of the skin's vital role in guarding against various environmental challenges as the body's largest protective organ and associated developments in biomaterials for wound healing. We first introduce the composition of skin tissue and intricate processes of wound healing, with special attention to the crucial role of immunomodulation in both acute and chronic wounds. This highlights how the imbalance in the immune response, particularly in chronic wounds associated with underlying health conditions such as diabetes and immunosuppression, hinders normal healing stages. Then, this review distinguishes between traditional wound healing strategies that create an optimal microenvironment and recent peptide-based biomaterials that modulate cellular processes and immune response to facilitate wound closure. Additionally, we highlight the importance of considering the stages of wounds in the healing process. By integrating advanced materials engineering with an in-depth understanding of wound biology, this approach holds promise for reshaping the field of wound management and ultimately offering improved outcomes for patients with acute and chronic wounds.

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Skin Structure and Function, Wound Healing and Scarring

Cited by 6 publications

References 29 publications

Development of novel alginate‐polyethyleneimine cell‐laden bioink designed for 3D bioprinting of cutaneous wound healing scaffolds

Development of novel alginate‐polyethyleneimine cell‐laden bioink designed for 3D bioprinting of cutaneous wound healing scaffolds

Angiopoietin-1 derived peptide hydrogel promotes molecular hallmarks of regeneration and wound healing in dermal fibroblasts

Biomaterials for immunomodulation in wound healing

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