2018
DOI: 10.1248/bpb.b18-00584
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Skin Sensitization to Fluorescein Isothiocyanate Is Enhanced by Butyl Paraben in a Mouse Model

Abstract: Contact hypersensitivity (CHS) to preservatives is receiving increased attention. Parabens are widely used in foods, pharmaceutics and cosmetics as preservatives. The skin sensitizing activity of parabens remains controversial but a few investigations have been made as to whether parabens could facilitate sensitization to other chemicals. We have shown that di-n-butyl phthalate (DBP), a phthalate ester, has an adjuvant effect in a fluorescein isothiocyanate (FITC)-induced CHS mouse model. We have also demonstr… Show more

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Cited by 7 publications
(2 citation statements)
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References 18 publications
(51 reference statements)
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“…4 lower panel). The response to a DNFB challenge is mediated by Th1 IFN-γ-inducing haptens, [18] whereas the response to a FITC challenge is mediated by a Th2 response [28]. Our results suggest that IL-19 can influence Th1-mediated CHS response through the regulation of IL-17-producing cells such as Th17 cells.…”
Section: Il-19 and Type IV Hypersensitivitymentioning
confidence: 85%
“…4 lower panel). The response to a DNFB challenge is mediated by Th1 IFN-γ-inducing haptens, [18] whereas the response to a FITC challenge is mediated by a Th2 response [28]. Our results suggest that IL-19 can influence Th1-mediated CHS response through the regulation of IL-17-producing cells such as Th17 cells.…”
Section: Il-19 and Type IV Hypersensitivitymentioning
confidence: 85%
“…In the brain, BP (200 mg/kg/d) increases the levels of NO, IL-6 and TNF-α but downregulates IL-1β (Hegazy et al, 2015). Peripherally, it can also enhance dendritic cell (DC) trafficking to draining lymph nodes (dLN) and increases the secretion of IL-4 and IFN-γ from dLNs (Matsuoka et al, 2018). During pregnancy, exposure to BP and PP associate with higher measures of oxidative stress, lower expression of c-reactive protein, and changes in cytokine secretion.…”
Section: Innate Immunity Effectsmentioning
confidence: 99%