Skin-related enzyme inhibitory activity by hydrolyzable polyphenols in water chestnut (Trapa natans) husk

Abstract

Water chestnut is a floating leaf plant native to Asia and Europe. Its fruit has long been used as an edible and herbal medicine. Water chestnut contains many polyphenols and its consumption can prevent lifestyle-related diseases because it has a suppressive effect on postprandial blood glucose elevation; however, its suitability as a cosmetic material is unknown. Therefore, this study aimed at investigating the antiaging effect of polyphenols contained in the husk of the devil water chestnut (Trapa natans). Six hydrolyzable polyphenols—1,6-di-O-galloyl-β-d-glucopyranose, 1,2,6-tri-O-galloyl-β-d-glucopyranose, 1,6-di-O-galloyl-2,3-O-(S)-hexahydroxydiphenoyl-β-d-glucopyranose (nobotanin D), eugeniin, 1,2,3,6-tetra-O-galloyl-β-d-glucopyranose, and trapain—were collected and isolated from the water chestnut husk. These polyphenols showed high antioxidant and antiglycation activities. In addition, inhibitory activities against hyaluronidase, elastase, and collagenase were observed. Especially, eugeniin and trapain, which have many gallic acids and a hexahydroxy-biphenyl group, showed high inhibitory activities. Thus, the polyphenols in water chestnut are beneficial for antiaging effects.

Targeting Desulfovibrio vulgaris flagellin-induced NAIP/NLRC4 inflammasome activation in macrophages attenuates ulcerative colitis

“…We speculate that eugeniin could be the most effective DVF/NAIP interaction interface inhibitor. Recent studies suggest that eugeniin possesses antioxidant and antiviral properties [58] , [59] . As such, we investigated its role in blocking the DVF/NAIP interaction, leading to suppressed caspase-1 activity and reduced GSDMD cleavage to inhibit macrophage pyroptosis.…”

Trapa bispinosa Roxb. Pericarp Extract Exerts 5α-Reductase Inhibitory Activity in Castrated Benign Prostatic Hyperplasia Model Mice

“…The phytochemical and pharmacological activities of the pericarp, which is considered a waste or byproduct, have been extensively studied [2]. TBE is an excellent source of antioxidants and has anti-glycation activities in vitro [3,4]. TBE is enriched with gallotannin derivatives, such as eugeniin; 1,6-or 2,3-Di-O-galloyl-β-D-glucose (DGG); 1,2,3,6-or 1,2,4,6-tetra-O-galloyl-D-glucose (TGG); 1,2,3,4,6-pentagalloyl glucose (PGG); and valoneic acid dilactone [1].…”