Skin rejuvenation using cosmetic products containing growth factors, cytokines, and matrikines: a review of the literature

Aldag, Caroline; Teixeira, Diana Nogueira; Leventhal, Phillip S.

doi:10.2147/ccid.s116158

Cited by 103 publications

(104 citation statements)

References 40 publications

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“…Thus, dermal and skin elasticities are important parameters to measure skin aging [23]. Dermal elasticity, however, was not analyzed in previous studies, because molecules loaded on topical cosmetic formulations have difficulty reaching the dermis and thus would not be expected to have a significant effect on the recovery of dermal elasticity [34]. The HO-DMNs solved this problem by overcoming the skin barrier limitation and delivering the HO to the dermis to improve both dermal and skin elasticity.…”

Section: Resultsmentioning

confidence: 99%

Skin Barrier Restoration and Moisturization Using Horse Oil-Loaded Dissolving Microneedle Patches

Lee

Eom

Yang³

et al. 2018

Skin Pharmacol Physiol

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Background: Horse oil (HO) has skin barrier restoration and skin-moisturizing effects. Although cream formulations have been used widely and safely, their limited penetration through the stratum corneum is a major obstacle to maximizing the cosmetic efficacy of HO. Therefore, we aimed to encapsulate HO in a cosmetic dissolving microneedle (DMN) for efficient transdermal delivery. Methods: To overcome these limitations of skin permeation, HO-loaded DMN (HO-DMN) patches were developed and evaluated for their efficacy and safety using in vitro and clinical studies. Results: Despite the lipophilic nature of HO, the HO-DMN patches had a sharp shape and uniform array, with an average length and tip diameter of 388.36 ± 16.73 and 38.54 ± 5.29 µm, respectively. The mechanical strength of the HO-DMN patches was sufficient (fracture force of 0.29 ± 0.01 N), and they could successfully penetrate pig skin. During the 4-week clinical evaluation, HO-DMN patches caused significant improvements in skin and dermal density, skin elasticity, and moisturization. Additionally, a brief safety assessment showed that the HO-DMN patches induced negligible adverse events. Conclusion: The HO-DMNs are efficient, safe, and convenient for wide use in cosmetic applications for skin barrier restoration and moisturization.

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Section: Resultsmentioning

confidence: 99%

Skin Barrier Restoration and Moisturization Using Horse Oil-Loaded Dissolving Microneedle Patches

Lee

Eom

Yang³

et al. 2018

Skin Pharmacol Physiol

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“…Synthetic peptides play an important role in the development of drugs, biomaterials, diagnostics, or cosmetics . Owing to the improvements in the chemical synthesis of peptides, the average length of peptides entering clinical development has increased from about nine amino acids in the 1980's to approximately 20 amino acids in the current decade .…”

Section: Introductionmentioning

confidence: 99%

A traceless catch‐and‐release method for rapid peptide purification

Reimann

Seitz

Sarma

et al. 2018

Journal of Peptide Science

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In contrast to peptide synthesis, peptide purification by high performance liquid chromatography (HPLC) cannot be easily varied in number and scale, which results in production restraints. Catch-and-release purification of peptides may help to ease HPLCrelated limitations and provides thus an alternative, allowing for fast protocols with great potential for parallelization and scale-up. This work depicts a unique combination of base-labile cleavable linkers with oxime-based and hydrazone-based ligation chemistry. For the first time, aminooxy or hydrazine functionalities are presented on site of the linker molecules. Aldehyde-functionalized agarose beads are used for immobilization on the solid phase, allowing a rapid and high yielding purification protocol. In this experimental set-up, many organic solvents or chaotropic reagents are accepted during immobilization, facilitating the dissolution of potentially hydrophobic or aggregation-prone peptides. Feasibility of the system is demonstrated with six peptides ranging from 15 to 31 residues in length, including very hydrophobic and thus challenging sequences like the palmitoyl modified liraglutide and an aggregation prone beta-amyloid fragment. Additionally, limitations of this system and the use of baselabile linkers are discussed and demonstrated.

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“…The skin consists of epidermis, dermis, and subcutaneous tissues, in that order from the outermost layer. 13) The stratum corneum in the outermost layer of the epidermis functions as a barrier against transepidermal water transpiration and physical stimulation from outside the body. 14) Previous reports investigating the effects of α-EG on the skin have mainly focused on the stratum corneum.…”

mentioning

confidence: 99%

“…The dermis consists mainly of collagen, elastin fibers, and other extracellular matrix components, as well as hyaluronic acid. 13,16) The collagen-rich extracellular matrix, produced by fibroblasts, forms the structure of the skin and gives it tensile strength and firmness. 13,17) Thus, dermal fibroblasts are an essential component of the skin and are involved in maintaining the structure of fibers.…”

mentioning

confidence: 99%

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Effects of ethyl-α-d-glucoside on human dermal fibroblasts

Bogaki

Mitani²,

Oura³

et al. 2017

Bioscience, Biotechnology, and Biochemistry

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Ethyl α-d-glucoside (α-EG) is a glycoside present in sake, Japanese rice wine. Previous studies have reported that α-EG suppresses skin roughness after ultraviolet B irradiation, transepidermal water loss, and hepatic function disorder, and has a skin moisturizing effect. In this study, 0.48 μM of α-EG was found to increase the proliferation of normal human dermal fibroblasts (NHDF) by 121.0%, and the amount of collagen I produced by NHDF increased by 159.6% at an α-EG concentration of 0.048 μM, compared to those in cells cultured without α-EG. In NHDF cultured in α-EG-supplemented medium, the expression of fibroblast growth factor I and VII mRNA increased by 148.8 and 153.1%, at an α-EG concentration of 4.8 and 0.048 μM, respectively, as measured by a quantitative reverse transcription-polymerase chain reaction. Transcript levels of type I collagen genes, COL1A1 and COL1A2, increased by 152.4 and 129.7%, respectively, and that of a type III collagen gene, COL3A1, increased by 131.8% at an α-EG concentration of 0.48 μM. These findings supported the possibility that α-EG was involved in the maintenance and improvement of skin homeostasis and moisturizing functions.

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Skin rejuvenation using cosmetic products containing growth factors, cytokines, and matrikines: a review of the literature

Cited by 103 publications

References 40 publications

Skin Barrier Restoration and Moisturization Using Horse Oil-Loaded Dissolving Microneedle Patches

Skin Barrier Restoration and Moisturization Using Horse Oil-Loaded Dissolving Microneedle Patches

A traceless catch‐and‐release method for rapid peptide purification

Effects of ethyl-α-d-glucoside on human dermal fibroblasts

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