Skin Reaction Induced by Aldehydes for Food Flavoring Agents.

Abstract

Guinea pigs were sensitized intracutaneously for 7 days (0.1 ml of 1% aldehyde solution/day) with nine aldehydes (p-anisaldehyde, benzaldehyde, citral, ethylvanillin, furfural, n-octanal, l-perillaldehyde, piperonal and vanillin) which are used as the food flavoring agents. Three weeks later, each aldehyde was injected by different concentrations (0.25-1.0%). Skin reactions were observed 24 hr after the injection of the aldehydes. All aldehydes tested exhibited a positive skin reaction, indicating that these aldehydes are capable of inducing an allergic reaction.

Perilla frutescens extract ameliorates DSS-induced colitis by suppressing proinflammatory cytokines and inducing anti-inflammatory cytokines

“…It has been reported that several bioactive compounds are present in P. frutescens leaves (17). Some volatile components, such as perillaldehyde and perilla ketone, which induce skin allergic reactions (48), were removed during the manufacturing process for the PE used in this study. In P. frutescens, LU, AG, and RA are representative bioactive ingredients.…”

Exploring the Structural Properties of Simple Aldehydes: A Monte Carlo and Small-Angle X-ray Scattering Study

“…As an extensive group of organic compounds, aldehydes are in general important substances that are in widespread use in various industrial processes and are also not to be neglected from the health-risk and ecological points of view. They are used for the synthesis of diverse chemicals and pharmaceuticals, as solvents, disinfectants, repellents, detergents, perfumes, and some even as food additives. − Due to their reactivity (they are able to interact with electron-rich biological macromolecules) they also raise adverse health issues such as general toxicity, allergenic reactions, mutagenicity, and carcinogenicity. − Our present interest lies in the simple aldehydes, i.e. linear alkanals, from propanal, butanal, pentanal, hexanal, heptanal, octanal, to nonanal.…”

“…They are used for the synthesis of diverse chemicals and pharmaceuticals, as solvents, disinfectants, repellents, detergents, perfumes, and some even as food additives. [1][2][3][4][5] Due to their reactivity (they are able to interact with electron-rich biological macromolecules) they also raise adverse health issues such as general toxicity, allergenic reactions, mutagenicity, and carcinogenicity. [5][6][7] Our present interest lies in the simple aldehydes, i.e.…”

Hepatic Metabolism of Methyl Anthranilate and Methyl N-Methylanthranilate as Food Flavoring Agents in Relation to Allergenicity in the Guinea Pig

“…We reported previously that flavoring aldehydes such as p-anisaldehyde and n-octanal elicited skin reactions in guinea pigs. 2) Thus it is very important to assess the safety of food flavoring agents in relation to their toxicokinetics.…”