Skin Protective Effect of Epigallocatechin Gallate

Kim, Eunji; Hwang, Kyeonghwan; Lee, Jongsung; Han, Sang Yun; Kim, Eun‐Mi; Park, Junseong; Cho, Jae Youl

doi:10.3390/ijms19010173

Cited by 115 publications

(88 citation statements)

References 54 publications

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“…Catechins also directly affect the skin by activating collagen synthesis and inhibiting the production of matrix metalloproteinase enzymes (Arct et al 2003). Because of the hydroxyl in the gallate group, EGCG and ECG are highly effective free-radical scavengers compared with many other standard anti-oxidants, such as ascorbic acid, tocopherol, and trolox (Gulati et al 2009;Matsubara et al 2013;Kim et al 2018). Because of these useful actions, tea catechins are increasingly used in medical, pharmaceutical, and cosmetic products and are being actively studied in a variety of approaches.…”

Section: Introductionmentioning

confidence: 99%

Activity of catechins and their applications

et al. 2020

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Background: Catechins, which are polyphenol compounds found in many plants and are an important component of tea leaves, are strong anti-oxidants. Research: Many studies seek to enhance the effects of catechins on the human body and boost their protective power against UV radiation. There are many examples of the positive anti-microbial, anti-viral, anti-inflammatory, anti-allergenic, and anti-cancer effects of catechins. Catechins increase the penetration and absorption of healthy functional foods and bio cosmetics into the body and the skin, thus improving their utility. High value-added antioxidant substances have been extracted from food and plant sludge, and experiments have shown that catechins are safe when applied to the human body. The stability of catechins is very important for their absorption into the human body and the effectiveness of their anti-oxidant properties.Conclusion: Continued research on the strong anti-oxidant effects of catechins is expected to result in many advances in the food, cosmetics, and pharmaceutical industries.

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Section: Introductionmentioning

confidence: 99%

Activity of catechins and their applications

et al. 2020

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“…MAPKs, which are composed of the ERK, JNK, and p38 subfamilies, are involved in various cellular responses, such as cell proliferation and differentiation, through the AP-1 signaling pathway [19,40]. HAS is enhanced through MAPK and IκBα-signaling pathways [40,41], and TGM-1 is regulated by the p38/MAPK pathway and NF-κB signaling [42]. To determine the mechanism of DTA in skin hydration and keratinocyte differentiation, we measured the phosphorylation of MAPKs and AP-1-mediated luciferase activity in DTA-treated cells.…”

Section: Discussionmentioning

confidence: 99%

In Vitro Effects of Dehydrotrametenolic Acid on Skin Barrier Function

et al. 2019

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Dehydrotrametenolic acid (DTA) is a lanostane-type triterpene acid isolated from Poria cocos Wolf (Polyporaceae). Several studies have reported the anti-inflammatory and antidiabetic effects of DTA; however, its effects on the skin are poorly understood. In this study, we investigated the effects of DTA on skin barrier function in vitro and its regulatory mechanism in human keratinocyte cell line HaCaT cells. DTA increased the microRNA (mRNA) expression of natural moisturizing factor-related genes, such as HAS-2, HAS-3, and AQP3 in HaCaT cells. DTA also upregulated the mRNA expression of various keratinocyte differentiation markers, including TGM-1, involucrin, and caspase-14. Moreover, the protein expression of HAS-2, HAS-3, and TGM-2 were significantly increased by DTA. To examine the regulatory mechanisms of DTA, Western blotting, luciferase-reporter assays, and RT-PCR were conducted. The phosphorylation of mitogen-activated protein kinases (MAPKs) and IκBα were increased in DTA-treated HaCaT cells. In addition, AP-1 and NF-κB transcriptional factors were dose-dependently activated by DTA. Taken together, our in vitro mechanism studies indicate that the regulatory effects of DTA on skin hydration and keratinocyte differentiation are mediated by the MAPK/AP-1 and IκBα/NF-κB pathways. In addition, DTA could be a promising ingredient in cosmetics for moisturizing and increased skin barrier function.

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“…Results showed no significant changes to lifespan (Strong et al, 2012). Although, the limited research of EGCG in connection to aging does not allow for definite conclusions, it has been widely used as a cosmetic for its potential skin protective effects its widely researched as a cosmetic additive having shown skin protective effects (Kim et al, 2018) and is available commercially in the form of green tea extract tablets.…”

Section: Green Tea Catechinsmentioning

confidence: 97%

An Appraisal on the Value of Using Nutraceutical Based Senolytics and Senostatics in Aging

Kaur

Macip

Stover

2020

Front. Cell Dev. Biol.

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The average human life expectancy has increased globally, and continues to rise, owing to the substantive progress made in healthcare, medicine, sanitation, housing and education. This ultimately enriches society with a greater proportion of elderly people. Sustaining a healthy aged population is key to diminish the societal and economic impact of age-related infirmities. This is especially challenging because tissue function, and thus wellbeing, naturally progressively decline as humans age. With age increasing the risk of developing diseases, one of the therapeutic options is to interfere with the molecular and cellular pathways involved in age-related tissue dysfunction, which is in part caused by the accumulation of senescent cells. One strategy to prevent this could be using drugs that selectively kill these cells (senolytics). In parallel, some compounds have been identified that prevent or slow down the progression of senescence or some of its features (senostatics). Senolytic and senostatic therapies have been shown to be efficient in vivo, but they also have unwanted dose-dependent side effects, including toxicity. Important advances might be made using bioactive compounds from plants and foods (nutraceuticals) if, as is proposed, they offer similar effectiveness with fewer side effects. The focus of this review is on the use of nutraceuticals in interfering with cellular senescence.

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Skin Protective Effect of Epigallocatechin Gallate

Cited by 115 publications

References 54 publications

Activity of catechins and their applications

Activity of catechins and their applications

In Vitro Effects of Dehydrotrametenolic Acid on Skin Barrier Function

An Appraisal on the Value of Using Nutraceutical Based Senolytics and Senostatics in Aging

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