Skin protection against UV radiation using thin films of cerium oxide

Ortiz, E.; Martínez-Gómez, L.; Valdés-Galicia, J. F.; Cuevas-García, R.; Anzorena, M.; Escalera, L. Martínez de la

doi:10.1051/radiopro/2019002

Cited by 3 publications

(2 citation statements)

References 15 publications

(16 reference statements)

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“…The main issues for organic UV filters are related to narrow UV absorbance, insufficient photostability, and toxicity, , whereas inorganic UV filters, such as TiO 2 , ZnO, and CeO 2 , are broad UV absorbers and highly photostable. − Unlike larger inorganic particles that can leave behind a chalky white residue, metal oxide nanoparticles (NPs) offer transparency, but concerns regarding nanosafety and photocatalytic activity exist . Overall, the use of inorganic UV blockers may be preferable considering recent studies linking the bleaching of coral reef to organic UV filters in sunscreens , and other studies showing the promise of CeO 2 NPs in skin protection. − …”

Section: Introductionmentioning

confidence: 99%

Nanocellulose-Based Hybrid Materials for UV Blocking and Mechanically Robust Barriers

Abitbol

Ahniyaz

Álvarez-Asencio

et al. 2020

ACS Appl. Bio Mater.

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Nanocellulose (NC)-based hybrid coatings and films containing CeO2 and SiO2 nanoparticles (NPs) to impart UV screening and hardness properties, respectively, were prepared by solvent casting. The NC film-forming component (75 wt % of the overall solids) was composed entirely of cellulose nanocrystals (CNCs) or of CNCs combined with cellulose nanofibrils (CNFs). Zeta potential measurements indicated that the four NP types (CNC, CNF, CeO2, and SiO2) were stably dispersed in water and negatively charged at pH values between 6 and 9. The combination of NPs within this pH range ensured uniform formulations and homogeneous coatings and films, which blocked UV light, the extent of which depended on film thickness and CeO2 NP content, while maintaining good transparency in the visible spectrum (∼80%). The addition of a low amount of CNFs (1%) reduced the film hardness, but this effect was compensated by the addition of SiO2 NPs. Chiral nematic self-assembly was observed in the mixed NC film; however, this ordering was disrupted by the addition of the oxide NPs. The roughness of the hybrid coatings was reduced by the inclusion of oxide NPs into the NC matrix perhaps because the spherical oxide NPs were able to pack into the spaces between cellulose fibrils. We envision these hybrid coatings and films in barrier applications, photovoltaics, cosmetic formulations, such as sunscreens, and for the care and maintenance of wood and glass surfaces, or other surfaces that require a smooth, hard, and transparent finish and protection from UV damage.

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Section: Introductionmentioning

confidence: 99%

Nanocellulose-Based Hybrid Materials for UV Blocking and Mechanically Robust Barriers

Abitbol

Ahniyaz

Álvarez-Asencio

et al. 2020

ACS Appl. Bio Mater.

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“…Similar SPF and UV‐shielding were observed for CeO 2 and TiO 2 , however, great improvement in photocatalytic activities and reduction of free radical generation were obtained by Ca 2+ coated CeO 2 nanoparticles 21 . In silico studies compared CeO 2 and TiO 2 films between 5 and 15 nm thick and showed that CeO 2 reduced the radiation dose more than 10% when compared to TiO 2 22 . Despite the necessity of tests to evaluate the stability, performance, and interaction with organic UV filters, CeO 2 showed a great potential as active ingredient.…”

Section: Cerium Dioxidementioning

confidence: 99%

A short review of alternative ingredients and technologies of inorganic UV filters

Nery

Martinez

Velasco

et al. 2020

J of Cosmetic Dermatology

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Background The growing need to use sunscreens is a concrete reality, and it is associated with the increase in the population's awareness of the ultraviolet (UV) radiation damage. Inorganic UV filters promote the formation of particles/pigments film over the skin surface, reflecting, dispersing, and absorbing the radiation. Investigations of this class of filters demonstrate the emergence of alternative ingredients and new technologies. Aims and Methods In this review, we presented potential candidates for alternative UV inorganic filters, such as hydroxyapatite, cerium dioxide, and hydrotalcite. Results Specialized literature identified hydroxyapatite and cerium dioxide as actives with good performances, with a broad spectrum of absorption against UV radiation. Both of them were considered safe against degradation and skin erythema formation. Inorganic compounds as an alternative to circumvent degradation problems of organic UV filters containing PABA were also analyzed, with hydrotalcite having a good performance in improving the performance of classic ingredients, bypassing photoinstability, and improving safety, in addition to preventing skin irritability. Conclusion Further investigations of these ingredients and interactions with sunscreen formulations are necessary to overall explore their safety and efficacy, encouraging future researches for more inorganic UV filters.

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Investigation of twenty metal, metal oxide, and metal sulfide nanoparticles' impact on differentiated Caco-2 monolayer integrity

et al. 2020

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The use of engineered nanomaterials (ENMs) in foods and consumer products is rising, increasing the potential for unintentional ingestion. While the cytotoxicity of many ENMs has been investigated, less attention has been given to adverse impact on the intestinal barrier integrity. Chronical disruption of gastrointestinal integrity can have far reaching health implications.Using fully differentiated Caco-2 cells, the perturbation of intestinal barrier function and cytotoxicity were investigated for 20 metal, metal oxide, and metal sulfide ENMs. Caco-2 cells were exposed to 50 μg/mL ENMs for 24 hours. ENM formulations were characterized at 0 and 24 hours, and In Vitro Sedimentation, Diffusion and Dosimetry Modeling was applied to calculate the effective dose of exposure during 24 hours. The apparent permeability coefficient (P app ) was determined for fluorescent labeled dextran (3,000 Da) and tight junction integrity was evaluated by immunofluorescence microscopy. Cytotoxicity was investigated by determining lactate dehydrogenase release (LDH) and cell metabolic activity (tetrazolium based MTS) assays.

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Skin protection against UV radiation using thin films of cerium oxide

Cited by 3 publications

References 15 publications

Nanocellulose-Based Hybrid Materials for UV Blocking and Mechanically Robust Barriers

Nanocellulose-Based Hybrid Materials for UV Blocking and Mechanically Robust Barriers

A short review of alternative ingredients and technologies of inorganic UV filters

Investigation of twenty metal, metal oxide, and metal sulfide nanoparticles' impact on differentiated Caco-2 monolayer integrity

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