Skin physiology in men and women: <i>in vivo</i> evaluation of 300 people including <scp>TEWL</scp>,<scp> SC</scp> hydration, sebum content and skin surface pH

Luebberding, Stefanie; Krueger, Nils; Kerscher, Martina

doi:10.1111/ics.12068

Cited by 172 publications

(170 citation statements)

References 39 publications

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“…While the surface pH of normal RHS in our study slightly exceeded the pH of other normal RHS [20] and normal skin in humans [37], the NMSC models captured a clear trend to increased pH values. The surface pH of the cSCC-ED model was very close to the extracellular pH 6.7-6.9 of solid tumors [38] and resulted from poorly differentiated SCC-12 cells [15].…”

Section: Discussioncontrasting

confidence: 65%

The barrier function of organotypic non-melanoma skin cancer models

Zoschke¹,

Ulrich

Sochorová

et al. 2016

Journal of Controlled Release

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Section: Discussioncontrasting

confidence: 65%

The barrier function of organotypic non-melanoma skin cancer models

Zoschke¹,

Ulrich

Sochorová

et al. 2016

Journal of Controlled Release

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“…Lipid esters were elevated following treatment with the test emollient; however, their penetration was limited. Sebum is a source of triglycerides (lipid esters) on the skin surface, and its production was found to decline in women with advancing age [52]. The level of total lipids, which includes non-physiological lipids (of white soft paraffin and liquid paraffin), increases significantly following treatment with both topical emollients.…”

Section: Discussionmentioning

confidence: 99%

The Effect of an Emollient Containing Urea, Ceramide NP, and Lactate on Skin Barrier Structure and Function in Older People with Dry Skin

Danby

Brown

Higgs-Bayliss

et al. 2016

Skin Pharmacol Physiol

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Xerosis affects up to 75% of older people and develops as a result of a skin barrier defect. Emollients are widely used to treat xerosis; however, there is limited understanding of the differences between them and their effects on the skin barrier in older people. This study aimed to compare the effect of a commercially available emollient containing 5% urea, ceramide NP and lactate (test emollient) to an alternative emollient without these additives (control emollient) on the properties of the skin barrier in older people. Two cohorts of 21 volunteers aged >60 years with dry skin were recruited. The first applied the test emollient to one forearm and no treatment to the other for 28 days. The second compared the test emollient to the control emollient observing the same parameters. Effects on the skin barrier were determined by measuring skin barrier function, hydration, skin surface pH and by analysing Fourier transform infrared spectra before and after treatment. A third cohort of 6 young adults was recruited to investigate the effect of a single treatment with the test emollient on the molecular structure of the skin barrier at greater depths by employing the tape-stripping technique. The test emollient hydrated the skin to a significantly greater extent and for a longer period of time compared to the control emollient, an effect associated with a significant elevation of carboxylate groups (a marker of natural moisturizing factor content) within the stratum corneum. Furthermore, the test emollient imparted additional benefits to the structure and function of the skin barrier not exhibited by the control emollient. In conclusion, the test emollient addressed the pathological features of xerotic aged skin, supporting its use as first-line therapy for xerotic skin conditions in this population.

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“…The biological process of wrinkle development largely depends on an age-related increase in TEWL and a decrease in sebum secretion (21). It is suggested that both an increase in stratum corneum hydration and a reduction of TEWL contribute to these effects.…”

Section: Discussionmentioning

confidence: 99%

Effects of Orally Administered Pyrroloquinoline Quinone Disodium Salt on Dry Skin Conditions in Mice and Healthy Female Subjects

Nakano

Kamimura²,

Watanabe³

et al. 2015

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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Summary Pyrroloquinoline quinone (PQQ) is a coenzyme involved in the redox-cycling system. The supplemental use of PQQ has been examined based on its properties as an antioxidant and redox modulator. Although an animal study on deficiency of PQQ suggested that PQQ contributes to skin conditions, its efficacy in humans has not been reported. The present study aimed to investigate the effects of orally administered PQQ on skin moisture, viscoelasticity, and transepidermal water loss (TEWL) both in dry skin mouse models and in healthy female subjects with a subjective symptom of dry skin. In our dry skin mouse model study, oral intake of PQQ (0.0089%, w/w, in the diet for 6 wk) significantly decreased the number of mast cells in the dermis and the number of CD31 T-cells in the epidermis. In our human study, oral intake of PQQ (20 mg/d for 8 wk) significantly inhibited the increase in TEWL on the forearm. Finally, subject questionnaires showed positive impressions for the improvement of skin conditions. These results suggest that oral intake of PQQ improves skin conditions both in female subjects with dry skin and in mice with a compromised skin barrier function.

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Skin physiology in men and women: in vivo evaluation of 300 people including TEWL, SC hydration, sebum content and skin surface pH

Abstract: Skin physiological distinctions between the sexes exist and are particularly remarkable with regard to sebum production and pH value.

Cited by 172 publications

References 39 publications

The barrier function of organotypic non-melanoma skin cancer models

The barrier function of organotypic non-melanoma skin cancer models

The Effect of an Emollient Containing Urea, Ceramide NP, and Lactate on Skin Barrier Structure and Function in Older People with Dry Skin

Effects of Orally Administered Pyrroloquinoline Quinone Disodium Salt on Dry Skin Conditions in Mice and Healthy Female Subjects

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