Skin perfusion pressure measured by radioisotope washout for predicting wound healing in lower limb amputation for arterial occlusive disease

Abstract

T. (1977). Skin perfusion pressure measured as the external pressure required to stop isotope washout. Methodological considerations and normal values on the legs. Scand. J. clin. Lab. Invest. 37,649-659. 11. Bolund, S. & Holstein, P. (1976). Blood flow cessation at external pressure in rat skin flaps. Isotope washout compared to vital capillary microscopy. Microvasc. Res. 11, 381-390. 111. Holstein, P., Nielsen, P. E. & Barras, J.-P. (1979). Blood flow cessation at external pressure in the skin of normal human limbs. Photoelectric recordings compared to isotope washout and to local intra-arterial blood pressure. Microvasc. Res. 17, 71-79.

A comparison of Doppler ankle pressures and skin perfusion pressure in subjects with and without diabetes

“…The same conclusion was reached by Holstein et al (1983) who compared skin perfusion pressure with systolic ankle pressure using a strain gauge in diabetic and non-diabetic subjects. This finding is consistent with the hypothesis that arteries in many diabetic subjects are less compressible than arteries in non-diabetic subjects.…”

“…This finding is consistent with the hypothesis that arteries in many diabetic subjects are less compressible than arteries in non-diabetic subjects. The same conclusion was reached by Holstein et al (1983) who compared skin perfusion pressure with systolic ankle pressure using a strain gauge in diabetic and non-diabetic subjects. Thus the ankle Doppler pressure may be falsely elevated over the whole range of pressures and not just in those with incompressible arteries.…”

“…A comparison of SPP on the dorsum of the foot with digital systolic pressure using a strain gauge may be more accurate (Holstein et al, 1983), but the measurement of digital pressure using a strain gauge is often inappropriate because the digits may be necrotic, may have been amputated, or be too painful for digital pressure measurements. A comparison of SPP on the dorsum of the foot with digital systolic pressure using a strain gauge may be more accurate (Holstein et al, 1983), but the measurement of digital pressure using a strain gauge is often inappropriate because the digits may be necrotic, may have been amputated, or be too painful for digital pressure measurements.…”

“…The relationship between SPP and ankle pressure is complex and this probably explains the low values for the regression coefficients. A comparison of SPP on the dorsum of the foot with digital systolic pressure using a strain gauge may be more accurate (Holstein et al, 1983), but the measurement of digital pressure using a strain gauge is often inappropriate because the digits may be necrotic, may have been amputated, or be too painful for digital pressure measurements.…”

Selection of amputation level in ischemia: Skin blood flow and perfusion pressure equally predictive

“…The benefit of peroperative determination of skin blood flow by the Xenon-133 technique (Moore 1973, Malone et al 1981, Harris et al 1986), as well as skin perfusion by the same method (Lassen et al 1974, Holstein et al 1979, Stackel et al 1982, or by the photoelectric method (Holstein 1985, Stackel et al 1982) is well established.…”