Skin penetration of caffeine from commercial eye creams and eye creams designed and optimized based on Hansen solubility parameters

Reyes, Roanne; Abou-Dahech, Mariam Sami; Nguyen, Gina; Smith, Amber M.; Homan, Ryan C. Devore; Schiefer, Isaac T.; Chandler, Mark; Baki, Gabriella

doi:10.1016/j.ijpharm.2023.122973

Cited by 4 publications

(1 citation statement)

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“…The surface free energy (γ) and solubility (δ) parameters of substances have received great attention owing to their fundamental and practical importance. − The two important characteristic parameters are closely related to many colloidal and interfacial phenomena such as dispersion, polymer dissolution, adsorption, adhesion, and wetting. − ,,− They are widely used for component selection in composite products such as coatings, pharmaceuticals, and cosmetics. ,− In particular, they have been recently widely used to select effective solvents in the fabrication of nanomaterials. ,− However, their determination for special substances such as solids and nonvolatile liquids is difficult and/or time-consuming. ,,,− It is essential to develop the correlations of the characteristic parameters (γ and δ) of substances with their easily measurable physical quantities so as to easily estimate their γ and δ parameters.…”

Section: Introductionmentioning

confidence: 99%

Correlations of Surface Free Energy and Solubility Parameters with Dielectric Constant, Refractive Index, and Density for Liquids

Wang,

Hou

2024

J. Phys. Chem. B

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There should be some intrinsic correlations between the surface free energy (γ) and solubility (δ) parameters, called characteristic parameters here, of substances with their fundamental physical properties such as the refractive index ( n D), relative dielectric constant (εr), and density (ρ) because they are all related to intermolecular interactions. Understanding the correlations between characteristic parameters and fundamental physical quantities is of great fundamental and practical importance. In the current work, possible relationships between the characteristic parameters (γ and δ) and the physical quantities (n D, εr, and ρ) were explored by a trial-and-error fitting method based on the data of 92 liquids (including 14 nonpolar, 37 polar, and 41 hydrogen-bonded liquids). The γ parameters include total (γt), dispersive (γd), and polar (γp) ones, and the δ parameters include the Hildebrand parameter (δt) and the Hansen-dispersive (δd), polar (δp), and hydrogen-bonded (δh) ones. For each characteristic parameter, its relationship with the physical quantities was established. The applicability of the so-obtained relationships was confirmed using the data of another 66 liquids as an external data set. The empirical relationships can be used to estimate the characteristic parameters of liquids from their easily measurable physical quantities.

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