Skin optical properties modifications using optical clearing agents: experimental and modelling results

Blondel, Walter; Rakotomanga, Prisca; Khairallah, Grégoire; Soussen, C.; Wu, Feng; Zhu, Danfeng; Chen, H.; Daul, Christian; Delconte, Alain; Marchal, Frédéric; Amouroux, Marine

doi:10.1109/lo.2018.8435250

Cited by 1 publication

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“…Currently, optical methods, such as photoacoustic and terahertz spectroscopy and visualization, and a number of other methods are widely used for the diagnosis and treatment of various diseases [1][2][3][4][5][6][7][8][9]. The use of optical methods is strongly limited to the small depth of probing tissues [9].…”

Section: Introductionmentioning

confidence: 99%

“…Enhancing image contrast due to dehydration and tissue optical clearing in the area of pathology is extremely important in the diagnosis of precancerous conditions, early stages of cancer and other diseases [1][2][3][4][5][6][15][16]. In a number of works, the difference in the content of free and bound water in the tissues was shown and an increased content of free water in the tumor tissues was found [17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

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Estimation of dehydration of skin by refractometric method using optical clearing agents

Lazareva

Dyachenko

Bucharskaya

et al. 2019

J-BPE

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Optical methods with highly sensitive to water content are important for the development of new diagnostic and therapeutic methods in medicine. The paper presents a quantitative assessment of the dehydration of skin when using optical clearing agents (glycerol and glucose) by the method of multi-wavelength refractometry for the visible and NIR spectral regions. The resulting decrease in the refractive index of the optical clearing solution made it possible to estimate the volume of the fluid extracted from the tissue. The possibility of using the method when conducting in vivo measurements is shown. An assessment was made of the degree of dehydration of rat skin in areas with a subcutaneous tumor neoplasm, which was three times less than for control (healthy) skin areas.

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