Skin Necrosis and Ulcers Induced by Medications

The negative impact of medications on wound healing

“…Heparin can cause adverse effects related to its anticoagulant effect such as purpura and haematomas either at the site of the injection or elsewhere. 46 Another adverse effect is heparin-induced thrombocytopaenia type II (HIT II) which may lead to arterial and venous thrombosis and subsequent skin necrosis. The mechanism of HIT is the formation of autoantibodies against heparin platelet factor 4 complexes.…”

“…The onset of HIT II is usually within the first 10-14 days of treatment, and the prevalence is approximately 0.1-2% of patients treated with heparin. 46 Direct Oral Anticoagulants (DOACs) DOACs are widely used and there have been reports of rare serious cutaneous side effects. 47 There have been two case reports of dabigatran causing leukocytoclastic vasculitis.…”