Skin mirrors human aging

Nikolakis, Georgios; Makrantonaki, Evgenia; Zouboulis, Christos C.

doi:10.1515/hmbci-2013-0018

Cited by 32 publications

(19 citation statements)

References 184 publications

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“…Any possible combination of benign and malignant collision skin lesions (CSLs) comprising melanocytic, epithelial, dermal or adnexal cells can occur in human skin [ 13 – 34 , 36 – 43 ]. Both intrinsic and extrinsic factors contribute to the likelihood of having two unrelated skin lesions occurring adjacent and contiguous with each other [ 44 ].…”

Section: Discussionmentioning

confidence: 99%

Collision skin lesions—results of a multicenter study of the International Dermoscopy Society (IDS)

Blum

Siggs²,

Marghoob

et al. 2017

Dermatol Pract Concept

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BackgroundCollision lesions as two independent and unrelated skin tumors often manifest an atypical morphology.ObjectiveTo determine the combinations of collision skin lesions (CSLs).MethodsTwenty-one pigmented lesion clinics in nine countries included 77 histopathologically proven CSLs in this retrospective observational study.ResultsSeventy-seven CSLs from 75 patients (median age 59.8 years) were analyzed; 24.7% of CSLs were located on the head and neck area, 5.2% on the upper extremities, 48.1% on the trunk, and 11.7% on the lower extremities; 40.3% revealed a melanocytic component (median age 54.7 years), followed by 45.5% with a basal cell carcinoma (BCC) (median age 62.4 years) and 11.7% with a seborrheic keratosis (median age 64.7 years). CSLs with a BCC component were more often found on the head and neck area compared to tumors with a melanocytic component (34.3% versus 16.1%). Lesions with a melanocytic component were more often detected on the trunk compared to lesions with a BCC (64.5% versus 37.1%). Patients with CSLs with epidermal-epidermal cell combination were older than patients with epidermal-dermal cell combination (63 versus 55.2 years), were more often male than female (63% versus 43.3%), more often had the lesion on the head and neck area (32.6% versus 13.3%), and less often on the upper (2.2 % versus 10%) or lower extremities (8.7% versus 16.6%).ConclusionsCSLs consist of a heterogeneous group of lesions of varying cell types. They are associated with advancing age and cumulative UV-exposure. CSLs manifest a complex morphology making it challenging to diagnose correctly.

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Section: Discussionmentioning

confidence: 99%

Collision skin lesions—results of a multicenter study of the International Dermoscopy Society (IDS)

Blum

Siggs²,

Marghoob

et al. 2017

Dermatol Pract Concept

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“…Aging is a complex, inevitable process influenced by a combination of endogenous and exogenous factors. Both types of factors induce cumulative morphological and physiological alterations and progressive changes in each layer of skin as well as influence the appearance of skin [1][2][3]. However, the most pronounced changes occur in elements of the dermis [2,4], which predominantly consists of connective tissue.…”

Section: Introductionmentioning

confidence: 99%

Transcriptome Profile of Human Fibroblasts in an Ex Vivo Culture

et al. 2020

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Implantation of autologous fibroblasts is a method used to correct age-related changes in facial skin. The aim of this study was to establish the optimal population of cultured human fibroblasts according to the organization of the extracellular matrix in the dermis. Transcriptome profile analysis of cells derived from three consecutive passages indicated that fibroblasts after the second passage were the population with the greatest number of upregulated genes encoding the critical biological processes responsible for skin regeneration, such as extracellular matrix organization, collagen fibril organization, and cell adhesion. Furthermore, genes encoding proteinases responsible for the degradation of dermal extracellular matrix proteins were noticeably downregulated at this stage of culture. Autologous fibroblasts seem to be an optimal and safe biological filler for the renewal of all skin structures.

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“…The skin is a mirror of aging [3]. Aging can be influenced by endogenous (intrinsic aging) and exogenous (extrinsic aging) factors.…”

Section: Introductionmentioning

confidence: 99%

Relation of Redox and Structural Alterations of Rat Skin in the Function of Chronological Aging

Janković

Saso

Korać

et al. 2019

Oxidative Medicine and Cellular Longevity

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Accumulation of oxidative insults on molecular and supramolecular levels could compromise renewal potency and architecture in the aging skin. To examine and compare morphological and ultrastructural changes with redox alterations during chronological skin aging, activities of antioxidant defense (AD) enzymes, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR), thioredoxin reductase (TR), and methionine sulfoxide reductase A (MsrA), and the markers of oxidative damage of biomolecules—4-hydroxynonenal (HNE) and 8-oxoguanine (8-oxoG)—were examined in the rat skin during life (from 3 days to 21 months). As compared to adult 3-month-old skin, higher activities of CAT, GSH-Px, and GR and a decline in expression of MsrA are found in 21-month-old skin. These changes correspond to degenerative changes at structural and ultrastructural levels in epidermal and dermal compartments, low proliferation capacity, and higher levels of HNE-modified protein aldehydes (particularly in basal lamina) and 8-oxoG positivity in nuclei and mitochondria in the sebaceous glands and root sheath. In 3-day-old skin, higher activities of AD enzymes (SOD, CAT, GR, and TR) and MsrA expression correspond to intensive postnatal development and proliferation. In contrast to 21-month-old skin, a high level of HNE in young skin is not accompanied by 8-oxoG positivity or any morphological disturbances. Observed results indicate that increased activity of AD enzymes in elderly rat skin represents the compensatory response to accumulated oxidative damage of DNA and proteins, accompanied by attenuated repair and proliferative capacity, but in young rats the redox changes are necessary and inherent with processes which occur during postnatal skin development. Мorphological and ultrastructurаl changes are in line with the redox profile in the skin of young and old rats.

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Skin mirrors human aging

Cited by 32 publications

References 184 publications

Collision skin lesions—results of a multicenter study of the International Dermoscopy Society (IDS)

Collision skin lesions—results of a multicenter study of the International Dermoscopy Society (IDS)

Transcriptome Profile of Human Fibroblasts in an Ex Vivo Culture

Relation of Redox and Structural Alterations of Rat Skin in the Function of Chronological Aging

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