Skin Microbiota Content in Children and its Effect on Acne Pathogenesis

The aim of the study was to study the efficacy and tolerability of the sequential use of the fixed combination of clindamycin + BPO in various clinical situations in real practice. Under our supervision there were 32 patients with mild-to-moderate and severe acne of papulo-pustular acne. Among them, 21 (65.6 %) female patients and 11 (34.4 %) male patients. The patients were divided into two groups: group 1 (teenage acne) of 17 people, group 2 (adult acne) of 15 people. The therapy algorithm included the use of a fixed combination of clindamycin + BPO (Zerkalin Intensive) for 4–5 weeks with a sequential transition to the use of a topical agent with adapalene for 6 months. All patients were prescribed specialized dermatocosmetics on an ongoing basis. As a result of therapy, after a week, there was a significantly significant change in all clinical symptoms of acne. So VAS (comedones) at the end of therapy decreased by 88.9 % (p < 0.01) and by 90.5 % (p < 0.01) in groups 1 and 2, respectively. Similar dynamics was noted in relation to inflammatory elements (papules, pustules). VAS (papules) in groups 1 and 2 decreased by 85.4 % (p < 0.01) and by 88.1 % (p < 0.01), VAS (pustules) – by 100 %. Thus, the use of a fixed combination of clindamycin + BPO causes a high therapeutic effect in relation to all clinical symptoms of acne.

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Skin Microbiota Content in Children and its Effect on Acne Pathogenesis

Cited by 2 publications

References 54 publications

Efficacy and safety of a fixed-dose combination of clindamycin and benzoyl peroxide in patients with acne

Efficacy and safety of a fixed-dose combination of clindamycin and benzoyl peroxide in patients with acne

Algorithm for managing patients with papulopustular acne

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