Skin microbiome transplantation and manipulation: Current state of the art

Callewaert, Chris; Knödlseder, Nastassia; Karoglan, Ante; Güell, Marc; Paetzold, Bernhard

doi:10.1016/j.csbj.2021.01.001

Cited by 64 publications

(61 citation statements)

References 88 publications

(60 reference statements)

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“…Several distinct strategies to restore or modulate the composition of the skin microbiome have been proposed [38][39][40] . Microbiome transplantation and bacterial replacement Fig.…”

Section: Modulating the Skin Microbiomementioning

confidence: 99%

Atopic dermatitis: an expanding therapeutic pipeline for a complex disease

Bieber

2021

Nat Rev Drug Discov

326

294

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“…Several distinct strategies to restore or modulate the composition of the skin microbiome have been proposed [38][39][40] . Microbiome transplantation and bacterial replacement Fig.…”

Section: Modulating the Skin Microbiomementioning

confidence: 99%

Atopic dermatitis: an expanding therapeutic pipeline for a complex disease

Bieber

2021

Nat Rev Drug Discov

326

294

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“…The bulk of basic research on skin microbiota and pathogen interaction presents a solid ground for developing probiotics to maintain healthy skin [ 109 ]. Probiotics can improve skin conditions either delivered directly to the skin (topical administration) or indirectly, such as oral probiotics [ 188 , 189 , 190 ]. A rather small number of studies in healthy subjects showed a remarkable positive effect of oral probiotics on skin health.…”

Section: Topical and Oral Probiotics In Skin Health And Diseases: State Of The Artmentioning

confidence: 99%

A Journey on the Skin Microbiome: Pitfalls and Opportunities

Pistone

Meroni

Panelli

et al. 2021

IJMS

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The human skin microbiota is essential for maintaining homeostasis and ensuring barrier functions. Over the years, the characterization of its composition and taxonomic diversity has reached outstanding goals, with more than 10 million bacterial genes collected and cataloged. Nevertheless, the study of the skin microbiota presents specific challenges that need to be addressed in study design. Benchmarking procedures and reproducible and robust analysis workflows for increasing comparability among studies are required. For various reasons and because of specific technical problems, these issues have been investigated in gut microbiota studies, but they have been largely overlooked for skin microbiota. After a short description of the skin microbiota, the review tackles methodological aspects and their pitfalls, covering NGS approaches and high throughput culture-based techniques. Recent insights into the “core” and “transient” types of skin microbiota and how the manipulation of these communities can prevent or combat skin diseases are also covered. Finally, this review includes an overview of the main dermatological diseases, the changes in the microbiota composition associated with them, and the recommended skin sampling procedures. The last section focuses on topical and oral probiotics to improve and maintain skin health, considering their possible applications for skin diseases.

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“…In double blind, placebo-controlled studies, certain probiotic strains were found to be beneficial in the treatment of childhood atopic dermatitis [81]. A full range of skin transplantation competitive exclusion strategies was recently reviewed by Callewaert et al [82].…”

Section: Barrier Integrity Regulation and Protectionmentioning

confidence: 99%

Microbiome First Approaches to Rescue Public Health and Reduce Human Suffering

Dietert¹

2021

Preprint

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The is a sequential article to an initial review suggesting that Microbiome First medical approaches to human health and wellness could both aid the fight against noncommunicable diseases and conditions (NCDs) and help to usher in sustainable healthcare. This current review article specifically focuses on public health programs and initiatives and what has been termed by medical journals as a catastrophic record of recent failures. Included in the review is a discussion of the four priority behavioral modifications (food choices, cessation of two drugs of abuse, and exercise) advocated by the World Health Organization as the way to stop the ongoing NCD epidemic. The lack of public health focus on the majority of cells and genes in the human superorganism, the microbiome, is highlighted as is the “regulatory gap” failure to protect humans, particularly the young, from a series of mass population toxic exposures (e.g., asbestos, trichloroethylene, dioxin, polychlorinated biphenyls, triclosan, bisphenol A and other plasticizers, polyfluorinated compounds, herbicides, food emulsifiers, high fructose corn syrup, certain nanoparticles, endocrine disruptors, obesogens). The combination of early life toxicity for the microbiome and connected human physiological systems (e.g., immune, neurological), plus a lack of attention to the importance of microbial rebiosis has facilitated rather than suppressed, the NCD epidemic. This review article concludes with a call to place the microbiome first and foremost in public health initiatives as a way to both rescue public health effectiveness and reduce the human suffering connected to co-morbid NCDs.

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Skin microbiome transplantation and manipulation: Current state of the art

Cited by 64 publications

References 88 publications

Atopic dermatitis: an expanding therapeutic pipeline for a complex disease

Atopic dermatitis: an expanding therapeutic pipeline for a complex disease

A Journey on the Skin Microbiome: Pitfalls and Opportunities

Microbiome First Approaches to Rescue Public Health and Reduce Human Suffering

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