Skin microbiome alterations in seborrheic dermatitis and dandruff: A systematic review

Tao, Rong; Li, Ruoyu; Wang, Ruojun

doi:10.1111/exd.14450

Cited by 45 publications

(57 citation statements)

References 44 publications

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“…Our findings of the alteration of the skin fungal community in SD were consistent with those of previous studies. 3,14 A recent systematic review showed that SD was associated with lower fungal diversity compared with healthy individuals, which is consistent with our findings. 3 On investigation of the fungal community and clinical parameters, our study showed a positive correlation between the abundance of Malassezia and disease diversity, indicating that this yeast is an important factor in the pathogenesis of SD.…”

Section: Discussionsupporting

confidence: 92%

Ketoconazole 2% cream alters the skin fungal microbiome in seborrhoeic dermatitis: a cohort study

Tao

Wang

Wan

et al. 2022

Clinical and Experimental Dermatology

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Summary Background Seborrhoeic dermatitis (SD) is a common chronic inflammatory dermatosis. Current theories on the pathogenesis of SD highlight the role of microbes on the skin surface. Ketoconazole is commonly used for the treatment of SD; however, there are limited data focusing on the effects of ketoconazole in shaping the skin microbiome in patients with SD. Aim In this prospective cohort study, we used a high‐throughput DNA sequencing method to characterize the cutaneous microbial communities of patients with SD before and after topical ketoconazole treatment. Methods In total, 30 patients with facial SD and 15 age‐ and sex‐matched healthy controls (HCs) were enrolled in this study. Skin swabs were collected from SD lesional sites of the cheek at baseline, after ketoconazole treatment and 2 weeks post‐treatment. DNA was extracted from skin samples. The bacterial 16S V3V4 rRNA and fungal internal transcribed spacer 1–5F regions were sequenced, and the microbial community compositions were analysed. Results Significantly lower bacterial and fungal diversities were detected at the lesional sites of facial SD compared with HCs. A decreased relative abundance of Cutibacterium and increased abundances of Malassezia and Staphylococcus were found in facial SD. Disease diversity was positively correlated with the relative abundances of Malassezia, Staphylococcus and Corynebacterium, while transepidermal water loss was negatively associated with the relative abundance of Cutibacterium. After ketoconazole treatment, fungal Shannon diversity and the relative abundances of Candida and Aspergillus were significantly increased at the lesional sites, and the relative abundance of Malassezia showed a decreasing trend. These changing trends were maintained until 2 weeks post‐treatment. Conclusion Facial SD showed lower fungal diversity accompanied by increased relative abundances of Malassezia and Staphylococcus and decreased relative abundance of Cutibacterium. Ketoconazole treatment reduced Malassezia and increased fungal diversity to restore skin microbial communities.

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Section: Discussionsupporting

confidence: 92%

Ketoconazole 2% cream alters the skin fungal microbiome in seborrhoeic dermatitis: a cohort study

Tao

Wang

Wan

et al. 2022

Clinical and Experimental Dermatology

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“…Staphyloccus is linked with epidermal barrier damage, including increased transepidermal water losses and pH, while Cutibacterium increases water content. Malassezia has also been associated with increased pruritus and disease severity ( Xu et al, 2016 ; Park et al, 2017 ; Tao et al, 2021 ).…”

Section: Seborrheic Dermatitismentioning

confidence: 99%

The Human Skin Microbiome in Selected Cutaneous Diseases

Carmona-Cruz

Orozco‐Covarrubias

Sáez‐de‐Ocariz

2022

Front. Cell. Infect. Microbiol.

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The human skin harbors a wide variety of microbes that, together with their genetic information and host interactions, form the human skin microbiome. The role of the human microbiome in the development of various diseases has lately gained interest. According to several studies, changes in the cutaneous microbiota are involved in the pathophysiology of several dermatoses. A better delineation of the human microbiome and its interactions with the innate and adaptive immune systems could lead to a better understanding of these diseases, as well as the opportunity to achieve new therapeutic modalities. The present review centers on the most recent knowledge on skin microbiome and its participation in the pathogenesis of several skin disorders: atopic and seborrheic dermatitis, alopecia areata, psoriasis and acne.

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“…Until present, heterogeneity exists between studies assessing the skin microbiome of psoriatic patients, especially the changing trend in the relative abundance of specific bacteria such as Staphylococcus 24–26 . These discrepancies may be due to differences in study population, sampling method, sequencing techniques and analysis method 25,27 . The choice of primers and sequencing targets is the main points of attention in skin microbiome design, and it has strong impact on study results 28 …”

Section: Discussionmentioning

confidence: 99%

“…[24][25][26] These discrepancies may be due to differences in study population, sampling method, sequencing techniques and analysis method. 25,27 The choice of primers and sequencing targets is the main points of attention in skin microbiome design, and it has strong impact on study results. 28 In our analysis, the abundance of T. rubrum, which is the most common pathogenic species of onychomycosis, was slightly higher in subjects with NP than psoriatic subjects without nail involvement (7.85% vs. 2.06%, NS).…”

Section: Con Clus I On and Per S Pec Tive Smentioning

confidence: 99%

Dysbiosis of nail microbiome in patients with psoriasis

Wang

Song

et al. 2022

Experimental Dermatology

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Shifts in skin microbiome are considered to be involved in the pathogenesis of psoriasis. However, data on the microbial dysbiosis of nail psoriasis are scarce. In this study, we aim to investigate and characterize the nail bacterial and fungal microbiome in patients with psoriasis. Nail samples were collected prospectively from 36 subjects with nail psoriasis, 24 psoriatic subjects without nail involvement and 32 healthy controls. Amplicon sequencing was performed to evaluate the bacterial and fungal community compositions. Significant alterations in the bacterial microbiome were found in the nail samples of psoriatic patients. The unaffected nails in psoriatic patients were associated with higher bacterial diversity, and a higher relative abundance of Enhydrobacter, whereas nail psoriasis was correlated with a decreased relative abundance of Anaerococcus. Shifts in fungal community composition were reflected by a higher proportion of Malassezia in the unaffected nails of psoriatic patients and an increased proportion of Candida in psoriatic nails. Shifts in the nail microbiome in psoriasis suggest a potential role of microbes in the development of nail psoriasis. Future researches focusing on these microorganisms may help to explain the pathogenesis of psoriasis.

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Skin microbiome alterations in seborrheic dermatitis and dandruff: A systematic review

Cited by 45 publications

References 44 publications

Ketoconazole 2% cream alters the skin fungal microbiome in seborrhoeic dermatitis: a cohort study

Ketoconazole 2% cream alters the skin fungal microbiome in seborrhoeic dermatitis: a cohort study

The Human Skin Microbiome in Selected Cutaneous Diseases

Dysbiosis of nail microbiome in patients with psoriasis

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