Skin metastasis from squamous cell carcinoma of the cervix to the lower extremities: Case report and review of the literature

Alrefaie, Sumayyah I; Alshamrani, Hussein M; Abduljabbar, Mohammed H; Hariri, Jehad

doi:10.4103/jfmpc.jfmpc_541_19

Cited by 7 publications

(2 citation statements)

References 27 publications

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“…Of these, three presented with cutaneous metastasis which preceded the diagnosis of cervical malignancy, specifically metastatic cervical squamous cell carcinoma and poorly differentiated carcinoma [2][3][4]6]. On review of the literature, four other reported cases have described cutaneous metastasis leading to a diagnosis of cervical cancer since then [7][8][9][10]. All four of these cases described metastatic cervical squamous cell carcinoma.…”

Section: Case Discussionmentioning

confidence: 98%

Cutaneous metastasis as a first sign of adenocarcinoma of the cervix

Gociman,

Florell,

Clarke

2023

DOJ

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Section: Case Discussionmentioning

confidence: 98%

Cutaneous metastasis as a first sign of adenocarcinoma of the cervix

Gociman,

Florell,

Clarke

2023

DOJ

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“…Nodules were the main form [21]. Other clinical manifestations includes maculopapular lesions, scar infiltration, and neoplastic alopecia [23].…”

Section: Discussionmentioning

confidence: 99%

Cutaneous metastasis from cervical cancer to the scalp and trunk: a case report and review of the literature

Dai,

Zhang,

et al. 2023

J Med Case Reports

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Background An estimated 119,300 new cases of cervical cancer occur annually in China, accounting for 372,00 deaths. Cutaneous metastasis from cervical cancer is a rare event, with an incidence of 0.1–1.3% and typically a preterminal occurrence. Scalp metastasis from cervical cancer is exceptionally anecdotal, with only a dozen examples well documented. Case presentation The patient is a 33-year-old Chinese woman who was diagnosed with International Federation of Gynecology and Obstetrics stage IVB cervical cancer in November 2021. From December 2021 to April 2022, the patient was enrolled in the clinical trial of sintilimab combined with chemotherapy and radiotherapy for treatment of stage IV cervical cancer and underwent six cycles of immunotherapy and chemotherapy (sintilimab plus paclitaxel liposome and cisplatin). Treatment was well tolerated and led to a partial response. The masses adjacent to the spine and iliac bone was largely reduced. Thus, radiotherapy of the metastatic residues was carried out and followed by radiotherapy to the primary tumor at the cervix uteri. However, by the time of the radiotherapy completion in October 2022, the patient noticed painless nodules at the left scapular region and the right hypochondrium. The following month, more nodules occurred on the scalp and trunk, including the left axilla, anterior abdomen, and left back, along with a lesion invading the sternum that caused acute bone pain. The cutaneous masses were white, discrete with a rubbery consistency, and fixed to the skin. Several nodules increased in size and eventually ulcerated. Fine‑needle aspiration cytology of the left back swellings revealed metastatic squamous cell carcinoma, P16 positive. No visceral or brain metastasis was observed at this point. Conclusions Cervical cancer metastases to the scalp are extremely uncommon. When a scalp metastasis is present, it might be the only symptomatic sign of disease progression or widespread metastatic lesions. So far, there is no clear guideline regarding skin metastases treatment. Such skin lesions warrant a thorough radiologic and pathologic workup to form a comprehensive management plan.

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Skin metastases originated from cervical cancer: A rare case report

Purbadi

Rustamadji

Purwoto

et al. 2021

Annals of Medicine &Amp; Surgery

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Introduction Metastases in cervical cancer could be spread through direct local invasion, lymphatic dissemination, or hematogenous dissemination. The most common sites of distant metastases are lungs, bone, and liver. Skin metastases from cervical cancer are categorized as a rare occurrence of metastases. This rarity of the cases has led us to report it. Case description A 66-year-old multiparous woman diagnosed with stage IIA cervical cancer seven years ago, then she came into our outpatient clinic complained about a brownish white color mass on the left side of the neck that keeps getting bigger over time came from a skin lesion. The lesion was first treated with topical steroid but there was no improvement. Biopsy was done and the result showed a carcinoma metastasis that led to adenosquamous carcinoma or cervical adenocarcinoma. The patient went through chemoradiation with biosensitizer paclitaxel 120 mg/m 2 for six cycles, which began in August 2019 until October 2019. The treatment progress showed a promising result. We observed the patient during treatment until two months after finishing the treatment. At the last visit, the patient came to our outpatient clinic, the mass size decreased significantly, and the skin showed an excellent regeneration sign. Conclusion The physicians should always consider the patient's history and pay more attention to skin lesions in patients with a history of cervical cancer. The physicians should also perform a thorough physical examination and biopsy to confirm the diagnosis.

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Skin metastasis from squamous cell carcinoma of the cervix to the lower extremities: Case report and review of the literature

Cited by 7 publications

References 27 publications

Cutaneous metastasis as a first sign of adenocarcinoma of the cervix

Cutaneous metastasis as a first sign of adenocarcinoma of the cervix

Cutaneous metastasis from cervical cancer to the scalp and trunk: a case report and review of the literature

Skin metastases originated from cervical cancer: A rare case report

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