Skin metastasis: A rare localization from laryngeal carcinoma and overview of similar cases

Azarhoush, R; Taziki, Mohammad Hossein; Golalipour, Mohammad Jafar; Arya, Bijan

doi:10.4103/0019-5154.45430

Cited by 6 publications

(9 citation statements)

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“…Squamous cell carcinoma is the most common histology of tumours originating in larynx. 13 They usually arise from glottis (59%), supraglottis (40%), or infraglottis (1%). 14 The disease usually spreads to regional lymph nodes or distant organs.…”

Section: Discussionmentioning

confidence: 99%

“…3 That too, metastasis to skin in a treated case of SCC of the larynx is extremely rare. [4][5][6][7][8][9][10][11][12] It generally denotes impending distant metastatic spread or locoregional recurrence, and poor prognosis. On review of literature, there were only few reports of cutaneous metastasis in treated SCC of larynx and limited information on potential treatment options.…”

Section: Introductionmentioning

confidence: 99%

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Skin metastasis within radiation field in treated squamous cell carcinoma of larynx

Selvaraj

Gudipudi

2020

Int J Otorhinolaryngol Head Neck Surg

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<p class="abstract">Cutaneous metastasis from squamous cell carcinoma (SCC) of larynx is very uncommon. Skin mestatsis in a treated of case of SCC larynx is considered to be a sign of impending distant metastasis and dismal prognosis. There are very few case reports in literature describing such presentations, and very minimal information on treatment options available for these patients. Here, we describe two cases of locally advanced SCC larynx treated with chemoradiation upfront, who later presented with cutaneous metastasis in neck within the previous radiation field. Evaluation for distant metastasis was done and started on palliative chemotherapy. The first patient had complete resolution of cutaneous nodules post 8 cycles of weekly palliative chemotherapy. However, post 18 cycles of chemotherapy, he developed a metachronous primary in upper thoracic oesophagus and disease progressed loco-regionally too. The second patient’s general condition deteriorated after 1st cycle of palliative chemotherapy, hence was offered best supportive care. Cutaneous nodules in a treated SCC of larynx must raise the suspicion of metastasis, warranting histological examination, and whole-body imaging work-up to rule out distant metastasis. Palliative chemotherapy must be advocated in all eligible patients to delay disease progression. Best supportive care can be offered in patients not eligible for chemotherapy.</p>

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Skin metastasis within radiation field in treated squamous cell carcinoma of larynx

Selvaraj

Gudipudi

2020

Int J Otorhinolaryngol Head Neck Surg

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“…This tumor may occur in various areas of the larynx including the supraglottic, such as aryepiglottic, false ropes, and ventricles, the gluteal area containing true vocal cords, anterior and posterior commissures, or the subglottic area below the vocal cords. The mild dysplasia seen in the larynx epithelium of some smokers may progress and lead to severe dysplasia and eventually in situ carcinoma, which is a prerequisite for the development of small invasive cancers and invasive squamous cell carcinoma [30]. Changes in the laryngeal epithelium in carcinoma occur in the form of white or red localized thickening, where irregularities are due to keratosis (increased superficial horny layers).…”

Section: Laryngeal Cancermentioning

confidence: 99%

“…Changes in the laryngeal epithelium in carcinoma occur in the form of white or red localized thickening, where irregularities are due to keratosis (increased superficial horny layers). Laryngeal carcinoma metastases occur during a long process of tumor growth and are usually confined to the surrounding tissues in the neck [31,32].…”

Section: Laryngeal Cancermentioning

confidence: 99%

A Review Study on the Prevalence of Helicobacter Pylori Infection in Laryngeal Carcinoma

2020

jcr

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Introduction: Malignant tumors of the larynx make up 2 to 5 percent of cancers each year. Infections can cause about 15% of the world's cancers with great environmental variations. One of the cases that have been investigated for its etiologic role in laryngeal carcinoma is Helicobacter pylori infection. Object: The aim of this review study is to investigate the available paper that evaluate association between Helicobacter pylori infection and laryngeal carcinoma. Material and method: Extensive research was conducted on some medical and microbiology database of life sciences such as Pub Med, EMBASE, MEDLINE, LILACS database, global independent network of Cochrane. By referencing these databases, a comprehensive literature review was carried out through combining numerous recent studies in terms of laryngeal carcinoma, Helicobacter pylori infection, epidemiology and management in accordance with many related articles published from 2000 to 2020 which could cover this area of recommendations. Conclusions: The Helicobacter pylori infection can affect the larynx cancer. Some studies investigated this relation. In this study we evaluated these studies. Different effect of Helicobacter pylori on larynx cancer was detected in these paper, some study showed strong effect of this infection in larynx cancer while another study reported any relation. So further studies needed to evaluate this relation although the Helicobacter pylori infection is main reason of many disease and its prevention and treatment is necessary.

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“…Nodular, inflammatory, telangiectatic, and bullous are various forms of clinical presentations of skin metastasis. [1] Nodular cutaneous metastasis is most commonly caused by lymphatic dissemination. [2] In a review of 4,020 patients with metastatic squamous cell carcinoma (SCC), cutaneous lesions occurred in 10.4%.…”

Section: Introductionmentioning

confidence: 99%

FDG PET/CT in a rare case of multiple cutaneous metastases in carcinoma larynx

et al. 2012

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Distant metastases in squamous cell carcinoma of the larynx have an incidence of 6.5-7.2% and most commonly involves the lungs, liver, and bone. Metastases to the skin are very rare, but, when present, they are usually considered a poor prognostic sign. This most often affect the supradiaphragmatic area, i.e., the head, neck, thorax, or upper extremities. We have reported 18F-fluorodeoxyglucose positron emission tomography computed tomography (FDG PET/CT) scan of a patient with squamous cell carcinoma of the larynx showing multiple subcutaneous nodules all over the body, which was helpful in the assessment as well as staging of the disease.

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Skin metastasis: A rare localization from laryngeal carcinoma and overview of similar cases

Cited by 6 publications

References 0 publications

Skin metastasis within radiation field in treated squamous cell carcinoma of larynx

Skin metastasis within radiation field in treated squamous cell carcinoma of larynx

A Review Study on the Prevalence of Helicobacter Pylori Infection in Laryngeal Carcinoma

FDG PET/CT in a rare case of multiple cutaneous metastases in carcinoma larynx

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