Skin melanoma survival is not superior in females in the new stage IIID of the 8th edition of the staging system: an analysis of data from the Surveillance, Epidemiology, and End Results (SEER) database

Mo, Ran; Chen, Chen; Ma, Lin; Ma, Zhouji; Tan, Qian

doi:10.21037/atm-20-3332

Cited by 7 publications

(6 citation statements)

References 19 publications

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“…On the other hand, once melanoma is diagnosed with central nervous system metastasis, its prognosis is abysmal (median OS is only 4 months) (23). The revision of the 8th edition of the AJCC (26,27). Moreover, our nomogram model suggested that stage IV CM patients without ulceration were better candidates for surgery for the first time.…”

Section: Discussionmentioning

confidence: 90%

“…Ulceration status is defined based on histopathologic examination of the absence of the complete epidermal allodermis over any part of the primary tumor with associated host response, and both the seventh and eighth editions of the AJCC staging guidelines consider ulceration as an additional T-category criterion ( 4 , 25 ). Previous studies have shown that both breslow tumor thickness and ulceration are independent prognostic factors for OS in CM patients; therefore, we discussed T-staging into two variables: Breslow tumor thickness (T1, T2, T3, and T4) and ulceration (Yes and No) during the study ( 26 , 27 ). Moreover, our nomogram model suggested that stage IV CM patients without ulceration were better candidates for surgery for the first time.…”

Section: Discussionmentioning

confidence: 99%

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Construction, validation and, visualization of a web-based nomogram to identify the best candidates for primary tumor resection in advanced cutaneous melanoma patients

Wei²,

Zheng³

et al. 2023

Front. Surg.

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BackgroundExisting studies have shown whether primary site resection (PSR) in cutaneous melanoma (CM) patients with stage IV is controversial. Our study aimed to identify the clinical characteristics of CM patients with stage IV who benefited from PSR on a population-based study.MethodsWe retrospectively reviewed stage IV CM patients in the Surveillance, Epidemiology, and End Results (SEER) database from 2004 to 2015. Patients were divided into surgical and non-surgical groups according to whether PSR was performed or not. According to the median cancer-specific survival (CSS) time of the non-surgery group, the surgical group was divided into the surgery-benefit group and the non-surgery-benefit group. Multivariate cox regression analysis was used to explore independent CSS prognostic factors in the surgical group. Then, based on the independent prognostic factors of the surgical group, we established a web-based nomogram based on logistics regression.ResultsA total of 574 stage IV CM patients were included in our study, and 491 (85.60%) patients were included in the surgical group. The clinical characteristics (benefit group and non-benefit group) included age, M stage, lesion location, and ulceration status. These independent prognostic factors were includeed to construct a web-based nomogram.ConclusionsWe constructed a web-based nomogram. This model was suitable for identifying the best candidates suitable for PSR in stage IV CM patients.

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Construction, validation and, visualization of a web-based nomogram to identify the best candidates for primary tumor resection in advanced cutaneous melanoma patients

Wei²,

Zheng³

et al. 2023

Front. Surg.

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“…High-risk melanomas are associated with equal to or greater than 50% risk of recurrence or death in 5-year perspective [23]. The introduction of the 8 th AJCC melanoma staging system caused controversies, nonetheless, it allowed to divide more accurately subgroups at high risk of relapse and death from the heterogeneous stage III group [24,25]. The predicted 5-year OS in accordance with the 7 th AJCC staging system varied from 78% to 40% (IIIA-C) and after the 8th update from 93% to 32% (IIIA-D) [19].…”

Section: Discussionmentioning

confidence: 99%

Survival of patients with stage IIIC and IIID melanomas with nodal metastases in the light of new therapies

Ziętek¹,

Zdzienicki²,

Wierzbicki³

et al. 2022

pdia

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Introduction: Within stage III melanoma prognosis and outcomes significantly vary. Advances in systemic therapy improved prognosis in metastatic melanoma. Adjuvant therapy in stage III significantly lowered relapses, although the effect on survival is less evident. Analysis of treatment results in stage IIIC and IIID before introduction of the modern adjuvant therapy, but after introduction of the effective systemic therapy in metastatic relapse, is needed. Aim: To analyse the clinical outcomes in patients with stage IIIC and IIID melanoma before the introduction of the novel adjuvant therapy. Material and methods: Consecutive stage IIIC and IIID melanoma patients treated in 2015-2018 in 4 reference centres in Poland were enrolled in the analysis of RFS and OS (in-transit metastases excluded). Median follow-up was 26.6 months (1.7-67. 2).Results: There were 224 stage IIIC and 49 stage IIID patients. Recurrence was observed in 170 (62.2%); 102 (45.5%) deaths in stage IIIC and 28 (57.1%) in stage IIID were reported. RFS and OS were better in stage IIIC compared to stage IIID. RFS and OS in the IIIC group were 19.7 and 36.2 months, respectively, and in IIID -8.9 and 27.8 months, respectively. Conclusions: The survival of patients with high-risk melanomas has improved in recent years, however, it is still unsatisfactory. The major changes in melanoma management related to the introduction of the adjuvant therapy require further careful observation.

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“…[14][15][16] Traditional prognostic factors for melanoma, including primary tumor thickness, ulceration, and age have been widely utilized for survival prediction. 14,[17][18][19] However, these factors may not fully capture the complexities associated with NM in the head and neck region. Therefore, there is a need to develop a survival prediction model that incorporates specific clinical and pathological characteristics relevant to NM in the head and neck.…”

Section: Introductionmentioning

confidence: 99%

A Prognostic Model for Cancer‐Specific Survival Among Patients with Nodular Melanoma in Head and Neck

Fan,

Gou,

et al. 2024

The Laryngoscope

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ObjectivesThis study aims to evaluate the correlation between risk factors and treatment methods affecting nodular melanoma (NM) in the head and neck, as well as cancer‐specific survival (CSS), and provide personalized predictive tools for clinical physicians.MethodsThe retrospective study data of 1848 patients were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. All variables were included in the correlation analysis using the Spearman method. Significant prognostic factors were extracted and integrated through Cox risk regression analysis to construct a nomogram. To assess the performance of the nomogram, Harrell's concordance index (C‐index) and a receiver operating characteristic (ROC) curve analysis were employed.ResultsSpearman's correlation analysis revealed a positive correlation between radiotherapy and lymph node metastasis, whereas chemotherapy showed a stronger association with distant metastasis. However, Cox risk regression analysis demonstrated that Mohs surgery and wide excision with margins exceeding 1 cm yielded substantial therapeutic advantages. Five independent risk prognostic factors (Breslow thickness, ulceration, N classification, M classification, and surgery type) were employed to construct a nomogram. The C‐index for this nomogram was 0.713 for the training set and 0.720 for the validation set. In the training set, the 3‐, 5‐, and 8‐year areas under the curve (AUCs) for CSS were 0.752, 0.723, and 0.720, whereas the validation set's AUCs were 0.754, 0.763, and 0.760, respectively. Calibration curves indicated the nomogram's strong discriminative ability for predicting CSS.ConclusionIn this study, we identified independent prognostic factors for patients with NM in head and neck and developed a relatively accurate model to predict the survival probability of them, which could contribute to the tumor assessment and clinical decision‐making.Level of EvidenceLevel 3 Laryngoscope, 2024

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Skin melanoma survival is not superior in females in the new stage IIID of the 8th edition of the staging system: an analysis of data from the Surveillance, Epidemiology, and End Results (SEER) database

Cited by 7 publications

References 19 publications

Construction, validation and, visualization of a web-based nomogram to identify the best candidates for primary tumor resection in advanced cutaneous melanoma patients

Construction, validation and, visualization of a web-based nomogram to identify the best candidates for primary tumor resection in advanced cutaneous melanoma patients

Survival of patients with stage IIIC and IIID melanomas with nodal metastases in the light of new therapies

A Prognostic Model for Cancer‐Specific Survival Among Patients with Nodular Melanoma in Head and Neck

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