Skin manifestations of the BNT162b2 mRNA COVID‐19 vaccine in healthcare workers. ‘COVID‐arm’: a clinical and histological characterization

Clinical and histopathological views of morbilliform rash after COVID-19 mRNA vaccination mimic those in SARS-CoV-2 virus infection-associated cutaneous manifestations

“…This vaccine comprises of mRNA encoding the SARS-CoV-2 spike protein enveloped in lipid nanoparticles. Recent reports have described that not negligible number of participants in clinical trials with mRNA vaccines, either BNT162b2 or Moderna (mRNA-1273), developed delayed injection site reaction, so called ‘COVID-arm’ [ 4 , 5 ]. However, there has been a quite few reports on maculopapular rash or morbilliform exanthema following mRNA vaccination [ 6 ].…”

Purpuric Skin Rash in a Patient Undergoing Pfizer-BioNTech COVID-19 Vaccination: Histological Evaluation and Perspectives

“…The authors hypothesized a delayed-type or T-cell mediated hypersensitivity reaction [ 23 ]. Fernandez-Nieto et al [ 32 ] and Johnston et al [ 33 ] also reported pruritic and variably painful erythematous reactions near the injection site. The histological picture presented a mild, predominantly perivascular and focal interstitial mixed infiltrate with lymphocytes and eosinophils, consistent with a dermal hypersensitivity reaction.…”

Localized cutaneous reaction to an mRNA COVID‐19 vaccine

“…5 Another study performed in Spain reviewed skin manifestations of 4775 participants who received this mRNA vaccine in a tertiary referral hospital. 6 Of these cases, 49 reported delayed injection site reactions after receiving the first dose. 6 An additional 54 participants reported this reaction following the F I G U R E 1 Cutaneous reaction to COVID-19 mRNA vaccine | 2381 LETTERS TO THE EDITOR second dose of the vaccine.…”

“…6 Of these cases, 49 reported delayed injection site reactions after receiving the first dose. 6 An additional 54 participants reported this reaction following the F I G U R E 1 Cutaneous reaction to COVID-19 mRNA vaccine | 2381 LETTERS TO THE EDITOR second dose of the vaccine. 6 Other reported skin manifestations included recurrent lesions following the second dose in 16 cases, pruritus in 70 cases, disseminated lesions in 5 cases, and urticarial reactions in 2 cases.…”

“…6 An additional 54 participants reported this reaction following the F I G U R E 1 Cutaneous reaction to COVID-19 mRNA vaccine | 2381 LETTERS TO THE EDITOR second dose of the vaccine. 6 Other reported skin manifestations included recurrent lesions following the second dose in 16 cases, pruritus in 70 cases, disseminated lesions in 5 cases, and urticarial reactions in 2 cases. 6 Cutaneous reactions from the vaccine range from mild to severe but are readily treatable.…”