Skin manifestations of Kikuchi-Fujimoto disease: case report and review

Abstract

The histopathological findings of cutaneous lesions in KFD are usually similar to those observed in the involved lymph nodes. This report suggests that interface change might be one of the pathological features of the cutaneous manifestations of KFD.

Kikuchi´s disease of the xanthomathous type with cutaneous manifestations

“… 1 , 3 , 4 It has been reported that up to 40% of patients with KD have cutaneous eruptions, but no specific skin changes have been described. 4 , 5 , 6 The most common skin manifestations are erythematous macules, papules, plaques, nodules and ulcers, localized on the face, on the upper and lower extremities and on the trunk. 1 , 4 , 5 , 8 In our patient, the first symptom of KD was the appearing of papules and with central suppuration, on her face and on her left hand.…”

“… 4 , 5 , 6 The most common skin manifestations are erythematous macules, papules, plaques, nodules and ulcers, localized on the face, on the upper and lower extremities and on the trunk. 1 , 4 , 5 , 8 In our patient, the first symptom of KD was the appearing of papules and with central suppuration, on her face and on her left hand. Posteriorly, she also complained of fever and cervical lymphadenopathy and on laboratory examination there was leukopenia.…”

“… 4 Most of the histopathological findings of cutaneous lesions, described in the literature, were perivascular or interstitial infiltration of lymphohistiocytes and nuclear debris. 4 , 5 …”

Interface dermatitis in skin lesions of Kikuchi–Fujimoto’s disease: a histopathological marker of evolution into systemic lupus erythematosus?

“…It mainly affects young people (mean age: 30 years, range: 6-75) 3 , particularly females (male: female ratio of 1:4), 4 with a striking predilection for the cervical nodes 5 (59-98%). 6 Common symptoms are fever (30-50%), 7 malaise (7%), 8 joint pain (7%), 8 chills, weight loss, diarrhoea, nausea, vomiting, sore throat and myalgia. 9,10 Laboratory studies usually reveal leucopenia (25-45.5%) 7 and elevated erythrocyte sedimentation rate (ESR) (40%).…”

“…6 Common symptoms are fever (30-50%), 7 malaise (7%), 8 joint pain (7%), 8 chills, weight loss, diarrhoea, nausea, vomiting, sore throat and myalgia. 9,10 Laboratory studies usually reveal leucopenia (25-45.5%) 7 and elevated erythrocyte sedimentation rate (ESR) (40%). 8 Association with ocular manifestations, [11][12][13] arthritis, 14,15,8 liver dysfunction and neurological complications (aseptic meningitis, [16][17][18][19] mononeuritis multiplex 20 or acute cerebellar ataxia 21 ) has also been described.…”