Skin manifestations of arsenicosis in two villages in Bangladesh

Kadono, Takafumi; Inaoka, Tsukasa; Murayama, Nobuko; Ushijima, Kayo; Nagano, Makoto; Nakamura, Satoshi; Watanabe, Chiho; Tamaki, Kunihiko; Ohtsuka, Ryutaro

doi:10.1046/j.1365-4362.2002.01668.x

Cited by 79 publications

(36 citation statements)

References 12 publications

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“…The evidence for burden of disease of arsenic due to drinking groundwater is still very sparse and accumulating (Rahman et al 2009). Arsenic leads to non-cancerous (non-malignant) and cancerous (malignant) health effects including cardiovascular disease (National Research Council 2001;Lee et al 2005;Chen et al 2009;Rahman et al 2009), peripheral neuropathy , decreased intellectual function (von Ehrenstein et al 2007), skin lesions (Haque et al 2003;McDonald et al 2007; Kadono et al 2002), skin cancers (Karagas et al 2001;Chen and Ahsan 2004), bladder cancer (Bates et al 2004) and lung cancer (Ferreccio et al 1998). Non-cancerous health effects of arsenic are commoner than cancerous health effects and lead to high burden of disease (Rahman et al 2009).…”

Section: Introductionmentioning

confidence: 99%

Lung function decrement with arsenic exposure to drinking groundwater along River Indus: a comparative cross-sectional study

Nafees

Kazi

Fatmi

et al. 2010

Environ Geochem Health

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This study was designed to determine the association between chronic arsenic exposure through drinking groundwater and decrement in lung function, particularly among individuals who do not have signs of arsenic lesions, among an adult population. This was a comparative cross-sectional study conducted during the months of January to March 2009. One hundred participants ≥15 years of age in each group, i.e. exposed (≥100 μg/l) and unexposed (≤10 μg/l) to arsenic, determined by testing drinking water samples (using portable kits), were compared for effects on lung function using spirometry. A structured and validated questionnaire was administered. Examination for arsenic skin lesions was also done. There was a decline in the mean adjusted FEV1 of 154.3 ml (95% CI: -324.7, 16.0; p = 0.076), in mean adjusted FVC of 221.9 ml (95% CI: -419.5, -24.3; p = 0.028), and in FEV1/FVC ratio of 2.0 (95% CI: -25.3, 29.4; p = 0.884) among participants who were exposed to arsenic compared to those unexposed. A separate model comprising a total of 160 participants, 60 exposed to arsenic concentrations ≥250 μg/l and 100 unexposed at arsenic concentrations of ≤10 μg/l, showed a decrement in mean adjusted FEV1 of 226.4 ml (95% CI: -430.4, -22.4; p = 0.030), in mean adjusted FVC of 354.8 ml (95% CI: -583.6, -126.0; p = 0.003), and in FEV1/FVC ratio of 9.9 (95% CI: -21.8, 41.6; p = 0.539) among participants who were exposed to arsenic in drinking groundwater. This study demonstrated that decrement in lung function is associated with chronic exposure to arsenic in drinking groundwater, occurring independently, and even before any manifestation, of arsenic skin lesions or respiratory symptoms. The study also demonstrated a dose-response effect of arsenic exposure and lung function decrement.

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Section: Introductionmentioning

confidence: 99%

Lung function decrement with arsenic exposure to drinking groundwater along River Indus: a comparative cross-sectional study

Nafees

Kazi

Fatmi

et al. 2010

Environ Geochem Health

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“…Nath et al [152] reported similar findings in their study population of Baruipur, South 24 Parganas district, West Bengal. Medical screening in the Bangladesh region [153] showed that most of the study populations were affected by keratosis and melanosis, whereas a few subjects were affected by chronic bronchitis and whole-body infection. In the West Bengal region, the individuals studied exhibited a full range of arsenical skin lesions, including hyperkeratosis, Bowen's disease (suspected), and non-healing ulcers (suspected cancer) [15,23,154].…”

Section: Bangladesh and West Bengal (India)mentioning

confidence: 99%

Natural Arsenic in Global Groundwaters: Distribution and Geochemical Triggers for Mobilization

et al. 2016

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The elevated concentration of arsenic (As) in the groundwaters of many countries worldwide has received much attention during recent decades. This article presents an overview of the natural geochemical processes that mobilize As from aquifer sediments into groundwater and provides a concise description of the distribution of As in different global groundwater systems, with an emphasis on the highly vulnerable regions of Southeast Asia, the USA, Latin America, and Europe. Natural biogeochemical processes and anthropogenic activities may lead to the contamination of groundwaters by increased As concentrations. The primary source of As in groundwater is predominantly natural (geogenic) and mobilized through complex biogeochemical interactions within various aquifer solids and water. Sulfide minerals such as arsenopyrite and As-substituted pyrite, as well as other sulfide minerals, are susceptible to oxidation in the near-surface environment and quantitatively release significant quantities of As in the sediments. The geochemistry of As generally is a function of its multiple oxidation states, speciation, and redox transformation. The reductive dissolution of As-bearing Fe(III) oxides and sulfide oxidation are the most common and significant geochemical triggers that release As from aquifer sediments into groundwaters. The mobilization of As in groundwater is controlled by adsorption onto metal oxyhydroxides and clay minerals. According to recent estimates, more than 130 million people worldwide potentially are exposed to As in drinking water at levels above the World Health Organization's (WHO's) guideline value of 10 μg/L. Hence, community education to strengthen public awareness, the involvement and capacity building of local stakeholders in targeting As-safe aquifers, and direct action and implementation of best practices in identifying safe groundwater sources for the installation of safe drinking water wells through action and enforcement by local governments and international water sector professionals are urgent necessities for sustainable As mitigation on a global scale.

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“…Arsenical hyperkeratosis appears predominantly on the palms and soles, and it has been found that keratosis on the soles is the most sensitive marker for the detection of arsenicosis at an early stage 38 . Keratoses are graded as mild, [Fig-4] moderate, or severe depending on the extent and severity 15 .…”

Section: Keratosismentioning

confidence: 99%