Skin lesions in ulcerative colitis.

Abstract

This paper is a study of the skin complications of ulcerative colitis. Between theyearsl949and 1965,415 patients, 230 women and 185 men, were admitted to the Central Middlesex Hospital suffering from this disease. Our object has been to determine the incidence and pattern of the skin disorders in this group and to try to discover if there is any relationship between the skin disease and the severity and extent of the colitis. Twenty patients had dermatoses associated with the bowel disorder and 12 were examined by one of us (H.T.H.W.). The morphological classification is based on these personally observed cases. The sex incidence showed that whereas 55 % of the whole series of colitics were women, 14 (70%) of those who had skin complications were women. Seven developed different types of lesion at different stages of the disease. The main conditions found were erythema nodosum (eight cases), pyoderma gangrenosum (seven cases), papulo-necrotic lesions (five cases), and ulcerating erythematous plaques on the shins (three cases). ERYTHEMA NODOSUMTender red nodes, generally appearing on the shins and associated with exacerbations of the colitis, occurred in eight patients, all women.The age of onset of erythema nodosum varied from 21 to 52 years (mean 29 years) and the skin lesions developed at any time from the onset of the first attack of colitis to 16 years later (mean 5*5 years). Although the attacks of erythema nodosum coincided with exacerbations of the colitis there was no correlation with the extent of the disease.

Mucocutaneous Manifestations of Inflammatory Bowel Disease in Turkey

“…The frequency of dermatologic complications was stated to be 2 to 35% in patients with UC and 9 to 23% in patients with CD in other reports. 22,23 In our study, patients with UC had far more mucocutaneous manifestations than patients with CD, but this difference was not statistically significant. Of 49 patients with mucocutaneous involvement (69.39%), 14 were female and 15 were male in our study.…”

Management of Peristomal Pyoderma Gangrenosum

“…Interestingly, the three patients with UC and the patient with indeterminate colitis had residual disease, which may have contributed to the development of PPG. It is known that PPG may not appear for some time after total colectomy, 23,24 and other authors also report that cutaneous manifestations of IBD do not always mirror disease in the bowel. 25,26 However, Tjandra et al report that the clinical outcome of PPG may be related to the activity of the underlying IBD or low-grade perineal sepsis.…”

Necrotizing vasculitis and ulcerative colitis.

“…Haematoma as the cause of skin necrosis can be ruled out. Pyoderma gangrenosum differs from necrotizing vasculitis-by its appearance and mode of onset and development (Johnson and Wilson, 1969). We have found only one description of a similar case (Goldgraber and Kirsner, 1960), in whioh the colitis was detected only at necropsy.…”