Skin lesions in histoplasmosis

Chang, Patricia; Rodas, Cecilia Beatriz

doi:10.1016/j.clindermatol.2012.01.004

Cited by 72 publications

(50 citation statements)

References 32 publications

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“…However, in DH, skin lesions can be highly variable, and mucous‐membrane lesions are found in 75% of cases . Our patient presented with a haemophagocytic syndrome and may have developed intestinal involvement, both of which have already been reported in DH …”

Section: Discussionmentioning

confidence: 54%

Disseminated histoplasmosis partially mimicking a dermatomyositis in a patient with rheumatoid arthritis

et al. 2015

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Histoplasma capsulatum var. capsulatum is a dimorphic fungus endemic to America and subtropical regions. Several cases of this opportunist mycosis have been reported in immunocompromised patients. We report the case of a patient treated with methotrexate and corticosteroid therapy for rheumatoid arthritis and who presented with disseminated histoplasmosis that partially mimicked a dermatomyositis.

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Section: Discussionmentioning

confidence: 54%

Disseminated histoplasmosis partially mimicking a dermatomyositis in a patient with rheumatoid arthritis

et al. 2015

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“…They are nonspecific, can mimic other etiologies including hematologic malignancy and hemophagocytic syndrome [13], and are responsible for delays in the diagnosis. PDH can also manifest skin involvement with several patterns like maculopapular lesions, pustules, nodules, ulcers, molluscum-like lesions, and keratotic plaques [14]. Skin lesions are reported in about 10% of patients with PDH from North America, while it can reach up to 93% in those from Latin America [14].…”

Section: Discussionmentioning

confidence: 99%

“…PDH can also manifest skin involvement with several patterns like maculopapular lesions, pustules, nodules, ulcers, molluscum-like lesions, and keratotic plaques [14]. Skin lesions are reported in about 10% of patients with PDH from North America, while it can reach up to 93% in those from Latin America [14]. Some authors have explained the higher frequency of skin lesions in patients from Latin America as the result of a delay in the diagnosis in these countries, a different tropism of the fungus and/or a greater virulence [15].…”

Section: Discussionmentioning

confidence: 99%

An Italian Case of Disseminated Histoplasmosis Associated with HIV

Papalini

Belfiori

Martino

et al. 2019

Case Reports in Infectious Diseases

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Histoplasma capsulatum is a dimorphic fungus, endemic in the Americas, Africa (var. duboisii), India, and Southeast Asia. H. capsulatum infection is rarely diagnosed in Italy, while in Latin America, progressive disseminated histoplasmosis (PDH) is one of the most frequent AIDS-defining illnesses and causes of AIDS-related deaths. We report a case of PDH and new HIV infection diagnosis in a Cuban patient, who has been living in Italy for the past 10 years. Bone marrow aspirate and peripheral blood smear microscopy suggested H. capsulatum infection. The diagnosis was confirmed with the culture method identifying its thermal dimorphism. Liposomal amphotericin B was administered alone for 10 days and then for another 2 days, accompanied with voriconazole; the former was stopped for probable side effects (persistent fever and worsening thrombocytopenia), and voriconazole was continued to complete 4 weeks. PDH maintenance treatment consisted of itraconazole for one year. Antiretroviral therapy (ART) was started on the third week of antifungal treatment. At the 3-year follow-up, the patient is adherent on ART, the virus was suppressed, and she has an optimal immune recovery. This case highlights the need to suspect histoplasmosis in the differential diagnosis of opportunistic infections in immunocompromised persons, native to or who have traveled to endemic countries.

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“…Rheumatologic and/or dermatologic manifestations occur in approximately 5% of patients. 2 Immunocompetent individuals usually present an acute pulmonary histoplasmosis which undergoes resolution without treatment.…”

Section: Doi: 101111/jtm12060mentioning

confidence: 99%

The Mycoarray as an Aid for the Diagnosis of an Imported Case of Histoplasmosis in an Italian Traveler Returning From Brazil

et al. 2013

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We describe an imported case of histoplasmosis, whose serological profile was established by means of a protein-based microarray platform, the recently described mycoarray. Because of its peculiarities, such a novel tool greatly facilitates the rapid and multiparametric assessment of patients' serological status and lends itself to be employed as an aid in the diagnosis of primary mycoses, especially in nonendemic countries.

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Skin lesions in histoplasmosis

Cited by 72 publications

References 32 publications

Disseminated histoplasmosis partially mimicking a dermatomyositis in a patient with rheumatoid arthritis

Disseminated histoplasmosis partially mimicking a dermatomyositis in a patient with rheumatoid arthritis

An Italian Case of Disseminated Histoplasmosis Associated with HIV

The Mycoarray as an Aid for the Diagnosis of an Imported Case of Histoplasmosis in an Italian Traveler Returning From Brazil

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