Skin lesions in angioimmunoblastic lymphadenopathy: histological and immunological studies

Abstract

Angioimmunoblastic lymphadenopathy with drysproteinaemia is reported (AILD) in four patients with different skin pictures. As the disease progresses two main forms predominate; papulonodular and erythroderma. In all cases the histological picture of the skin mirrors that of the lymph-node. Our results point to an increase in the peripheral blood, lymph-nodes and skin of T and subsequently of B lymphocytes suggesting that a proliferation of helper T cells and hence activation of the B-cell subpopulation may be involved in the pathogenesis of some cases of AILD.

Polymorphism analysis of Epstein-Barr virus isolates from patients with cutaneous natural killer/T-cell lymphoproliferative disorders: A possible relation to the endemic occurrence of these diseases in Japan

“…In our study, however, none of the healthy Japanese adults harbored EBV subtype 2 in their oropharyngeal regions. Dual infection with EBV subtypes 1 and 2 usually occurs in patients with immunodeficiency [Bernengo et al, 1981;Borisch et al, 1993] but rarely in patients with infectious mononucleosis and EBV-seropositive individuals with a normal immune response to EBV [Lung et al, 1988;Sculley et al, 1990]. In this study, co-infection was found in a patient with NK-cell lymphocytosis (Table I).…”

Cutaneous Involvement in Patients With Angioimmunoblastic Lymphadenopathy With Dysproteinemia<subtitle>A Clinical, Immunohistological, and Molecular Analysis</subtitle>

“…[21][22][23] Indeed, only 2 of 10 patients presented with infiltrated plaques that were clinically suggestive of a cutaneous T-cell lymphoma. On the contrary, 8 patients presented with nonspecific cutaneous features such as maculopapular morbilliform eruptions and urticarial or purpuric lesions.…”

Lymphomes T angio-immunoblastiques

“…La présentation dermatologique est le plus souvent aspécifique, peu évocatrice du diagnostic de lymphome, et plus en faveur d'un exanthème viral ou d'une réaction d'hypersensibilité médi-camenteuse [16]. Il s'agit dans la plupart des cas d'éruptions morbilliformes ou maculopapuleuses, parfois transitoires, prédo-minant au niveau du tronc ou généralisées [16,17,[27][28][29]. D'autres types de lésions peuvent être observés : un purpura infiltré ou non, parfois nécrotique, des plaques infiltrées, des nodules, en général violacés, une urticaire ou une érythroder-mie avec desquamation secondaire [16,17,[27][28][29][30][31].…”