Skin layer mechanics

Geerligs, M Marion

doi:10.6100/ir657803

Cited by 5 publications

(1 citation statement)

References 116 publications

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“…Its multilayer structure provides mechanical protection against external stimuli, obstruction of pathogenic microorganisms invasion and regulation of homeostasis related processes. Skin tissue layers can be broadly classified in three main categories: (i) the first layer known as epidermis hosts a number of different cell types such as keratinocytes, melanocytes, Langerhans and Merkel cells, constituting the first line of defense but with limited mechanical stability, (ii) the intermediate layer known as dermis, which can be divided into the papillary outer portion that comprises a loose interpenetrating network of fibrils and the reticular matrix that retains much thicker fibril formulations, thus resulting in enhanced mechanical tensile strength and (iii) the outmost inner layer designated as hypodermis, which is rich in lipid cells that are glued together by the mediation of small ECM isles [ 200 ].…”

Section: Applications Of Bioprinting In Tissue and Organ Regenerationmentioning

confidence: 99%

Advances in 3D bioprinting for regenerative medicine applications

Loukelis,

Koutsomarkos,

Mikos

et al. 2024

Regenerative Biomaterials

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Biofabrication techniques allow for the construction of biocompatible and biofunctional structures composed from biomaterials, cells and biomolecules. Bioprinting is an emerging 3D printing method which utilizes biomaterial-based mixtures with cells and other biological constituents into printable suspensions known as bioinks. Coupled with automated design protocols and based on different modes for droplet deposition, 3D bioprinters are able to fabricate hydrogel-based objects with specific architecture and geometrical properties, providing the necessary environment that promotes cell growth and directs cell differentiation towards application-related lineages. For the preparation of such bioinks, various water-soluble biomaterials have been employed, including natural and synthetic biopolymers, and inorganic materials. Bioprinted constructs are considered to be one of the most promising avenues in regenerative medicine due to their native organ biomimicry. For successful application, the bioprinted constructs should meet particular criteria such as optimal biological response, mechanical properties similar to the target tissue, high levels of reproducibility and printing fidelity, but also increased upscaling capability. In this review, we highlight the most recent advances in bioprinting, focusing on the regeneration of various tissues including bone, cartilage, cardiovascular, neural, skin, and other organs such as liver, kidney, pancreas, and lungs. We discuss the rapidly developing co-culture bioprinting systems used to resemble the complexity of tissues and organs and the crosstalk between various cell populations towards regeneration. Moreover, we report on the basic physical principles governing 3D bioprinting, and the ideal bioink properties based on the biomaterials’ regenerative potential. We examine and critically discuss the present status of 3D bioprinting regarding its applicability and current limitations that need to be overcome to establish it at the forefront of artificial organ production and transplantation.

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Section: Applications Of Bioprinting In Tissue and Organ Regenerationmentioning

confidence: 99%

Advances in 3D bioprinting for regenerative medicine applications

Loukelis,

Koutsomarkos,

Mikos

et al. 2024

Regenerative Biomaterials

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Polymeric micelle gel with luliconazole: in vivo efficacy against cutaneous candidiasis in Wistar rats

Singh,

Narang

2024

Naunyn-Schmiedeberg's Arch Pharmacol

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Influencia de los Parámetros Tribológicos en el Coeficiente de Fricción entre Polipropileno y Piel

2014

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ResumenSe adquirieron los datos sobre la topología superficial de sockets para amputados transfermorales utilizando un microscopio de fuerzas atómicas (AFM), se caracterizaron las propiedades tribológicas de 12 zonas significativas, a partir de estos datos se crearon superficies virtuales con geometría sinusoidal de 250m de área, las cuales fueron empleadas para llevar a cabo una simulación numérica para encontrar cual era la relación entre dichos parámetros y el coeficiente de fricción entre el polipropileno del socket y la piel. La piel se modeló como un material híper-elástico y el polipropileno como un material elástico lineal, se impuso un desplazamiento inicial de contacto y un desplazamiento tangencial de las probetas para calcular el coeficiente de fricción, adicionalmente, se aplicó una presión a la parte superior de las probetas de polipropileno que simulan las presiones generadas por el calzado de la prótesis y las fuerzas generadas durante la fase de apoyo de la marcha humana. Se encontró que existe una correlación entre los 1

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Skin layer mechanics

Cited by 5 publications

References 116 publications

Advances in 3D bioprinting for regenerative medicine applications

Advances in 3D bioprinting for regenerative medicine applications

Polymeric micelle gel with luliconazole: in vivo efficacy against cutaneous candidiasis in Wistar rats

Influencia de los Parámetros Tribológicos en el Coeficiente de Fricción entre Polipropileno y Piel

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