Skin-infiltrating T cells and cytokine expression in Icelandic horses affected with insect bite hypersensitivity: A possible role for regulatory T cells

Heimann, M.; Janda, Jozef; Sigurðardóttir, Ólöf; Svansson, Vilhjálmur; Klukowska, J.; Tscharner, C. von; Doherr, Marcus G.; Broström, Hans; Andersson, Lisa; Einarsson, Sigurjón; Marti, Eliane; Torsteinsdóttir, Sigurbjörg

doi:10.1016/j.vetimm.2010.11.016

Cited by 48 publications

(53 citation statements)

References 59 publications

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“…In addition, C. nubeculosus-specific IgE serum levels were found in IBH-affected horses (Heimann et al, 2011). Such a finding is comparable with the situation in other animals such as the dog, where significantly higher flea-specific IgE levels where found in cases of flea allergy dermatitis (FAD) than in healthy dogs (Halliwell andLongino, 1985, McKeon andOpdebeeck, 1994).…”

Section: Discussionsupporting

confidence: 71%

“…Differences in cell types present in the skin and as a potential consequence in functional immunological aspects between IBH "on and off" season may be indicative for processes underlying the disease. In general, IBH is thought to be a Type-1 hypersensitivity with a potential Th2 skewed immune responsiveness (Hamza et al, 2007, Heimann et al, 2011.…”

Section: Discussionmentioning

confidence: 99%

“…Expression levels of IL13 mRNA, but not of IL4 or IL5 mRNA, have been described to be significantly elevated in lesional and non-lesional skin of IBHaffected horses (Heimann et al, 2011). On the other hand, IL10 mRNA levels were lower in lesional compared to non-lesional skin, but this difference was not statistically significant (Heimann et al, 2011).…”

Section: Introductionmentioning

confidence: 97%

“…On the other hand, IL10 mRNA levels were lower in lesional compared to non-lesional skin, but this difference was not statistically significant (Heimann et al, 2011). An increase in IL4 mRNA production with a concomitant decrease in IFNγ mRNA production by cultured equine PBMC was observed during the IBH season (Hamza et al, 2007, Hamza et al, 2008, Hamza et al, 2010.…”

Section: Introductionmentioning

confidence: 98%

“…However, Culicoides-specific IgE serum titers have been reported to be higher in horses with IBH (Wilson et al, 2001, Hellberg et al, 2006, Wagner et al, 2006, Heimann et al, 2011) as compared to healthy horses. Correlations between Culicoides-specific IgE titers and histological scores for IBH have not been reported so far, nor have differences in these disease parameters between the IBH season and off season been investigated.…”

Section: Introductionmentioning

confidence: 98%

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Seasonal differences in cytokine expression in the skin of Shetland ponies suffering from insect bite hypersensitivity

Meulenbroeks

Meide

Zaiss

et al. 2013

Veterinary Immunology and Immunopathology

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Insect bite hypersensitivity (IBH) in horses is a seasonal, IgE-mediated, pruritic skin disorder primarily caused by Culicoides spp.We hypothesize that a mixed Th2/Th1-type immune status, off season, alters into Th2-dominated immune reactivity in the skin of IBH-affected ponies in the IBH season. 2To study these immune response patterns Culicoides-specific IgE levels, skin histopathology and cytokine and transcription factor mRNA expression (IL4, IL10, IL13, IFNγ, FoxP3 and CD3 ζ ) in lesional and non-lesional skin of ponies affected by IBH in the IBH season were compared with those of the same animals off season and those in skin of healthy ponies in both seasons.The present study revealed a significantly higher histopathology score in lesional skin of affected ponies than in non-lesional skin and skin of healthy ponies in the IBH season. C. obsoletus-specific IgE serum levels of ponies with IBH were significantly higher than those in healthy ponies in both seasons. obsoletus-specific IgE did not correlate with higher histological scores in LE skin.In summary, our data indicate a general immune activation in the skin of both healthy and IBH-affected ponies during the IBH season that potentially obscures the Culicoides-specific immune reaction pattern, even in lesional skin of IBHaffected animals.3

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Section: Discussionsupporting

confidence: 71%

Section: Discussionmentioning

confidence: 99%