Skin hyperreactivity. response (pathergy) in Behçet's disease

Gilhar, Amos; Winterstein, G.; Turani, H; Landau, Jacob M.

doi:10.1016/s0190-9622(89)70224-3

Cited by 52 publications

(25 citation statements)

References 14 publications

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“…A distinguishing feature of BS, on the other hand, is the paucity of granuloma formation [41]. A complement system is also not generally activated in BS nor is an immune complex-mediated injury [67]. There has been a recent attempt to amalgamate BS with the autoinflammatory diseases, the prototype of which is familial Mediterranean fever [68].…”

Section: Pathogenesismentioning

confidence: 99%

The Unique Features of Vasculitis in Behçet’s Syndrome

Melikoğlu¹,

Kural-Seyahi²,

Tascilar³

et al. 2008

Clinic Rev Allerg Immunol

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The presence of a true vasculitis is difficult to discern in some of the more common manifestations of Behçet's syndrome, like the papulopustular lesions of the skin. On the other hand, a true vasculitis is seen in all vessel sizes in the majority of the patients. The pathogenesis is not yet known. A Th1-type inflammatory reaction is seen like in some other primary vasculitides. However, in contrast to other vasculitides, granuloma formation is absent. Behçet's syndrome is unique among the vasculitides with its differing geographic distribution in disease expression, the distinctly more severe disease among the male, the predominance of venous disease, and the generally abating disease course with lack of associated increased atherosclerosis.

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Section: Pathogenesismentioning

confidence: 99%

The Unique Features of Vasculitis in Behçet’s Syndrome

Melikoğlu¹,

Kural-Seyahi²,

Tascilar³

et al. 2008

Clinic Rev Allerg Immunol

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“…The pathergy phenomenon seen in BS, that is a cutaneous hyperreactivity following minor trauma [12] , means that patients with BS are prone to problems at the incision site [13] . Fortunately, our patient has not experienced any such complications.…”

Section: Discussionmentioning

confidence: 99%

Colonic perforation in Behçet’s syndrome

Dowling¹,

Hill²,

Malone³

et al. 2008

WJG

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A 17-year-old gentleman was admitted to our hospital for headache, the differential diagnosis of which included Behçet's syndrome (BS). He developed an acute abdomen and was found to have air under the diaphragm on erect chest X-ray. Subsequent laparotomy revealed multiple perforations throughout the colon. This report describes an unusual complication of Behcets syndrome occurring at the time of presentation and a review of the current literature of reported cases.

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“…MSU reaction is the persistence of erythema 48 hours after an intradermal inoculation of MSU crystals. Both reactions demonstrate skin hypersensitivity and are high specific for Behçet's disease (Gilhar et al, 1989). Enrolled patients randomised to receive etanercept (25mg twice a week) or placebo.…”

Section: Mucocutaneous and Joint Diseasementioning

confidence: 99%