Skin hydration as a tool to control the distribution and molecular effects of intermediate polarity compounds in intact stratum corneum

Pham, Quoc Dat; Grégoire, Sébastien; Biatry, Bruno; Cassin, G.; Topgaard, Daniel; Sparr, Emma

doi:10.1016/j.jcis.2021.06.097

Cited by 7 publications

(4 citation statements)

References 55 publications

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“…The corneocytes can be seen as water-rich regions filled with keratin filaments, containing both hydrophilic and hydrophobic amino acids . Previous studies , also showed that chemicals can be taken up by corneocytes even under dry condition without water.…”

Section: Resultsmentioning

confidence: 99%

“…It is also possible that the dissolution of any added chemical inside the SC will lead to a shift in the solid–fluid balance toward higher content of fluid components. This may also lead to changes in the mobility of added chemicals in SC. , …”

Section: Resultsmentioning

confidence: 99%

“…This may also lead to changes in the mobility of added chemicals in SC. 7,53 The present methodology can be extended to also determine the distribution of an added chemical between different regions of a complex biomaterial by measuring the solubility in each of the regions in conditions that correspond to the same equilibrium. With respect to the present system, it is possible to extract the distribution of an added compound between the corneocytes and the extracellular lipids within the SC.…”

Section: Methods To Distinguish and Quantify Molecules That Are Taken...mentioning

confidence: 99%

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Solubility of Foreign Molecules in Stratum Corneum Brick and Mortar Structure

et al. 2023

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The barrier function of the skin is mainly assured by its outermost layer, stratum corneum (SC). One key aspect in predicting dermal drug delivery and in safety assessment of skin exposure to chemicals is the need to determine the amount of chemical that is taken up into the SC. We here present a strategy that allows for direct measures of the amount of various solid chemicals that can be dissolved in the SC in any environmental relative humidity (RH). A main advantage of the presented method is that it distinguishes between molecules that are dissolved within the SC and molecules that are not dissolved but might be present at, for example, the skin surface. In addition, the method allows for studies of uptake of hydrophobic chemicals without the need to use organic solvents. The strategy relies on the differences in the molecular properties of the added molecules in the dissolved and the excess states, employing detection methods that act as a dynamic filter to spot only one of the fractions, either the dissolved molecules or the excess solid molecules. By measuring the solubility in SC and delipidized SC at the same RHs, the same method can be used to estimate the distribution of the added chemical between the extracellular lipids and corneocytes at different hydration conditions. The solubility in porcine SC is shown to vary with hydration, which has implications for the molecular uptake and transport across the skin. The findings highlight the importance of assessing the chemical uptake at hydration conditions relevant to the specific applications. The methodology presented in this study can also be generalized to study the solubility and partitioning of chemicals in other heterogeneous materials with complex composition and structure.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Methods To Distinguish and Quantify Molecules That Are Taken...mentioning

confidence: 99%

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Solubility of Foreign Molecules in Stratum Corneum Brick and Mortar Structure

et al. 2023

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“…Given that PCA‐Na has a lower vapor pressure than water, it acts as a barrier, impeding the biogel from undergoing dehydration. [ 18 ] Furthermore, PCA‐Na, with its mobile Na + ions, imparts ionic conductivity to GP biogel. The conductivity of the biogel increases with increasing PCA‐Na concentration, reaching ≈25 mS cm −1 in GP biogel with 40 wt% PCA‐Na (black curve in Figure 2f).…”

Section: Resultsmentioning

confidence: 99%

Skin‐Inspired All‐Natural Biogel for Bioadhesive Interface

Lan,

Ping,

et al. 2024

Advanced Materials

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Natural material‐based hydrogels are considered ideal candidates for constructing robust bio‐interfaces due to their environmentally sustainable nature and biocompatibility. However, these hydrogels often encounter limitations such as weak mechanical strength, low water resistance, and poor ionic conductivity. Here, inspired by the role of natural moisturizing factor (NMF) in skin, we propose a straightforward yet versatile strategy for fabricating all‐natural ionic biogels that exhibit high resilience, ionic conductivity, resistance to dehydration, and complete degradability, without necessitating any chemical modification. A well‐balanced combination of gelatin and sodium pyrrolidone carboxylic acid (an NMF compound) gives rise to a significant enhancement in the mechanical strength, ionic conductivity, and water retention capacity of the biogel compared to pure gelatin hydrogel. The biogel manifests temperature‐controlled reversible fluid‐gel transition properties attributed to the triple‐helix junctions of gelatin, which enables in situ gelation on diverse substrates, thereby ensuring conformal contact and dynamic compliance with curved surfaces. Due to its salutary properties, the biogel can serve as an effective and biocompatible interface for high‐quality and long‐term electrophysiological signal recording. These findings provide a general and scalable approach for designing natural material‐based hydrogels with tailored functionalities to meet diverse application needs.This article is protected by copyright. All rights reserved

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How to induce antiaging in plastic surgery

Tosun

Bagci

2023

Beauty, Aging, and AntiAging

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Skin hydration as a tool to control the distribution and molecular effects of intermediate polarity compounds in intact stratum corneum

Cited by 7 publications

References 55 publications

Solubility of Foreign Molecules in Stratum Corneum Brick and Mortar Structure

Solubility of Foreign Molecules in Stratum Corneum Brick and Mortar Structure

Skin‐Inspired All‐Natural Biogel for Bioadhesive Interface

How to induce antiaging in plastic surgery

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