Skin Flow The Venoarteriolar Response and Capillary Filtration in Diabetics. A 3-year Follow-Up

Belcaro, Gianni; Nicolaides, Andrew; Volteas, N.; León, M.L. Villalobos

doi:10.1177/000331979204300606

Cited by 54 publications

(92 citation statements)

References 9 publications

(1 reference statement)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The present patient did not have congestive heart failure, arrhythmia or hypotension and had not taken vasoconstrictive drugs. However, our patient did have diabetic neuropathy, probably inducing abnormal microcirculation (8). Abnormalneurogenic regulation of microvascular haemodynamicsmay contribute to the deterioration ofmesenteric microcirculation.…”

Section: Discussionmentioning

confidence: 62%

Diabetes Mellitus Accompanied by Nonocclusive Colonic Ischemia.

Nagai¹,

Tomizawa²,

Monden

et al. 1998

Intern. Med.

View full text Add to dashboard Cite

A 70-year-old man with diabetic triopathy was hospitalized with left lower quadrant abdominal pain and tenderness, muscle guarding and absent bowel sounds. Three hours after admission, creatine phosphokinase (CPK) was elevated and an abdominal plain film X-ray showed intestinal gas retention, indicating paralytic ileus due to inferior mesenteric artery occlusion. Urokinase (60,000 units/day) and heparin (10,000 units/day) were administered. Angiography showed no occlusion in the mesenteric artery. On the 16th day, the abdominal signs had disappeared and CPK was normalized. We diagnosed this case as nonocclusive colonic ischemia because of the hemorheological abnormalities due to diabetic triopathy and the hypercoagulable state. (Internal Medicine 37: 454-456, 1998)

show abstract

Section: Discussionmentioning

confidence: 62%

Diabetes Mellitus Accompanied by Nonocclusive Colonic Ischemia.

Nagai¹,

Tomizawa²,

Monden

et al. 1998

Intern. Med.

View full text Add to dashboard Cite

show abstract

“…Our results are comparable to the baseline data from the majority of other studies [7, 8, 33, 34, 35, 37, 38, 39], where BSBF in diabetic patients, although lower in absolute terms, did not differ significantly from BSBF in healthy controls. On the contrary, Belcaro et al [44]found increased resting skin blood flow in the feet of diabetic patients with neuropathy when compared to diabetic patients without neuropathy and control subjects. Similar results were obtained by Fromy et al [45], who found mean BSBF in diabetic patients without neuropathy to be similar to that in control subjects and lower than that in diabetic patients with subclinical and clinical neuropathy.…”

Section: Discussionmentioning

confidence: 96%

Skin Blood Flow in the Upper and Lower Extremities of Diabetic Patients with and without Autonomic Neuropathy

et al. 2004

View full text Add to dashboard Cite

Background: Microvascular blood flow in the human skin is subject to rhythmic variations reflecting the influence of heartbeat, respiration, intrinsic myogenic activity, neurogenic factors and endothelial activity. The aim of our study was to test the hypothesis that basal skin blood flow (BSBF) and its dynamic components differ (1) among diabetic patients without autonomic neuropathy and with it and healthy control subjects, and (2) among the upper and lower extremities. Patients and Methods: BSBF at four recording sites with predominantly nutritive capillary circulation (right and left caput ulnae, right and left medial malleolus) was measured by laser Doppler flowmetry in 25 diabetic patients without cardiovascular autonomic neuropathy (D), 18 neuropathic diabetic patients (DAN) and 36 healthy controls (C). Wavelet transform was applied to the laser Doppler signal. Results: In absolute terms, mean flow, mean amplitude of the total spectrum and mean amplitudes at all frequency intervals were highest in C, followed by DAN and lowest in D. However, these differences were statistically significant only in the left arm. Within all three groups, mean flow and spectral amplitudes were significantly higher in the arms than in the legs, besides there was a significant difference between the two arms in D. Conclusion: We have confirmed the differences in BSBF among D, DAN and C, and demonstrated differences among the four recording sites which have not been previously described. The latter indicates an uneven progression of autonomic neuropathy and allows for speculation that the left arm is the latest to be affected.

show abstract

“…In particular, the capability of effective precapillary vasoconstriction on standing is reduced. This exposes the capillary bed to a high hydrostatic load, producing oedema and thickening of the capillary basement membrane [43]. These stresses are thought to evoke an inflammatory response in the microvascular endothelium, with a subsequent release of extravascular matrix proteins.…”

Section: Structural Microvascular Changes In Diabetesmentioning

confidence: 99%

Microvascular dysfunction in diabetic foot disease and ulceration

Chao

Cheing

2009

Diabetes Metabolism Res

167

129

View full text Add to dashboard Cite

Diabetic foot disease and ulceration is a major complication that may lead to the amputation of the lower limbs. Microangiopathy may play a significant role in the pathogenesis of tissue breakdown in the diabetic foot. However, the precise mechanisms of this process remain unclear and poorly understood. Microvasculature in the skin is comprised of nutritive capillaries and thermoregulatory arteriovenous shunt flow. It is regulated through the complex interaction of neurogenic and neurovascular control. The interplay among endothelial dysfunction, impaired nerve axon reflex activities, and microvascular regulation in the diabetic patient results in the poor healing of wounds. Skin microvasculature undergoes both morphologic changes as well as functional deficits when parts of the body come under stress or injury. Two important theories that have been put forward to explain the abnormalities that have been observed are the haemodynamic hypothesis and capillary steal syndrome. With advances in medical technology, microvasculature can now be measured quantitatively. This article reviews the development of microvascular dysfunction in the diabetic foot and discusses how it may relate to the pathogenesis of diabetic foot problems and ulceration. Common methods for measuring skin microcirculation are also discussed.

show abstract

Skin Flow The Venoarteriolar Response and Capillary Filtration in Diabetics. A 3-year Follow-Up

Cited by 54 publications

References 9 publications

Diabetes Mellitus Accompanied by Nonocclusive Colonic Ischemia.

Diabetes Mellitus Accompanied by Nonocclusive Colonic Ischemia.

Skin Blood Flow in the Upper and Lower Extremities of Diabetic Patients with and without Autonomic Neuropathy

Microvascular dysfunction in diabetic foot disease and ulceration

Contact Info

Product

Resources

About