Skin Flap Physiology and Wound Healing

Chu, Eugene A.; Byrne, Patrick J.; Odland, Rick M.; Goding, George S.

doi:10.1016/b978-0-323-05283-2.00080-x

Cited by 3 publications

(3 citation statements)

References 248 publications

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“…Although the preliminary study found that a dose of 1 g/flap was able to provide effective results, further research is needed with different doses and routes of administration and a longer examination time, considering that revascularization occurs as early as 7 days after flap elevation. (Chu et al, 2010)…”

Section: Vegf Administration To Increase Flap Viabilitymentioning

confidence: 99%

Administration of botulinum toxin a and vascular endhotelial growth factor reduce norepinephrine levels and increase viability of modified mcfarlane flap in wistar rat

Purwanthi

Hamid

Mahadewa

et al. 2022

ijhs

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Local hyperadrenergic states after a random flap elevation mediated by humoral vasoconstrictors can lead to flap necrosis. This study aimed to evaluate the effect of Botulinum Toxin A (BoNT-A) on reducing levels of Norepinephrine (NE) as the main humoral vasoactive substance, as well as its additive effect with Vascular Endothelial Growth Factor (VEGF) in increasing the viability of random flap. 28 Wistar Rats with Caudally Based Modified McFarlane Flap were divided into four groups. Group I received BoNT-A 3 days before flap elevation, group II received VEGF immediately after flap elevation, group III received a combination of BoNT-A and VEGF, group IV was a control group. Result in this study NE levels lowest was found in the BoNT-A+VEGF combination group (94.63 ± 5 .25 ng/ml, p<0.05 in group I, p<0.01 in groups II and IV). The highest value of FVR was shown in the BoNT-A+VEGF combination group (93.37 ± 2.19 %, p < 0.05 in group I, p < 0.01 in groups II and IV). Meanwhile, the increase in flap viability in the VEGF group was not statistically significant. So Conclusion administration of BoNT-A in combination with VEGF can increase the viability of random flaps by decreasing NE levels.

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Section: Vegf Administration To Increase Flap Viabilitymentioning

confidence: 99%

Administration of botulinum toxin a and vascular endhotelial growth factor reduce norepinephrine levels and increase viability of modified mcfarlane flap in wistar rat

Purwanthi

Hamid

Mahadewa

et al. 2022

ijhs

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show abstract

“…There are three phases of wound healing-inflammatory, proliferation, and remodeling. 32 Typically, wound closure is considered complete by the third week, and the remodeling stage is entered 33 ; therefore, monitoring prior to this point should be performed for any signs of infection, tissue loss, or dehiscence.…”

Section: Common Postoperative Considerationsmentioning

confidence: 99%

Soft Tissue Trauma to the Nose: Management and Special Considerations

Basa

Ezzat

2021

Facial Plast Surg

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The nose is one of the most common sites of facial injury due to its prominence and anatomical placement. Given its intricate anatomy, function, and high visibility, it also proves to be one of the most complex regions for repair. We provide a review of the management of soft tissue injuries to the nose, including the various reconstructive tools available and adjunctive wound care measures. We also discuss special considerations based on mechanism of injury and treatment of this condition in the pediatric population. The main goals of reconstruction should be to preserve function while achieving optimal cosmetic results in this highly visible region of the face.

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“…Smoking tobacco is associated with flap necrosis, either through direct endothelial damage, vasoconstriction via catecholamine release, or local concentrations of prostaglandins, which may contribute to decreased capillary blood flow. 2 Other disease states that may have a deleterious effect on blood flow, such as diabetes and peripheral vascular disease, may place patients at a higher risk for postoperative complications. Irradiated tissue is also not ideal for flap survival.…”

Section: Making Good Scars and Flaps Preoperative Evaluationmentioning

confidence: 99%

Enhanced Contouring of Local Flaps

Sclafani

Lin

2018

Facial plast Surg

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Scars and flaps represent a disruption of the normal skin contour, shape, and texture. Successful reconstruction of facial defects with local flaps requires prior planning to choose the correct reconstructive method. However, thorough preoperative planning should include consideration of adjunctive procedures to improve expected postoperative results as well as potential procedures to improve less-than-ideal results. Approaching facial reconstruction holistically allows the surgeon to soberly assess his/her reconstructive results and attain outstanding appearance.

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Skin Flap Physiology and Wound Healing

Cited by 3 publications

References 248 publications

Administration of botulinum toxin a and vascular endhotelial growth factor reduce norepinephrine levels and increase viability of modified mcfarlane flap in wistar rat

Administration of botulinum toxin a and vascular endhotelial growth factor reduce norepinephrine levels and increase viability of modified mcfarlane flap in wistar rat

Soft Tissue Trauma to the Nose: Management and Special Considerations

Enhanced Contouring of Local Flaps

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