Skin expression of IL‐1β in East Atlantic salmon, Salmo salar L., highly susceptible to Gyrodactylus salaris infection is enhanced compared to a low susceptibility Baltic stock

Lindenstrøm, Thomas; Sigh, Jens; Dalgaard, Michael B.; Buchmann, Kurt

doi:10.1111/j.1365-2761.2006.00696.x

Cited by 44 publications

(51 citation statements)

References 22 publications

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“…The notion that at least most of the Baltic strains of Atlantic salmon, with one exception (Bakke et al 2004), are less susceptible to Gyrodactylus salaris infection compared to the East Atlantic strains (Bakke et al 1990, Bakke & MacKenzie 1993, Dalgaard et al 2003, Lindenstrøm et al 2006, Heinecke & Buchmann 2006 is supported by the present investigation. This study showed a clear antiparasitic response in River Ume Älv salmon after 4 wk of infection, whereas the Danish River Skjernå salmon from the western part of Denmark exhibited a continous increase in the parasite load during the entire period.…”

Section: Discussionsupporting

confidence: 72%

“…The mechanisms involved in the response have not been finally resolved. An inappropriate (and possibly parasite-promoting) hyperactivation of IL-1β genes in susceptible Scottish salmon was found by Lindenstrøm et al (2006) (Goodburn et al 2000). Therefore, the results of this study could either be explained by immigration of T-cells, T-cell equivalents or NK-cells from the vascular system to the infected fin epidermis or could be interpreted as increased expression of resident T-cells or NK-cells in fin tissue.…”

Section: Discussionmentioning

confidence: 60%

“…In contrast, a range of East Atlantic strains of salmon are highly susceptible and do not activate effective anti-parasitic responses against this particular parasite (Bakke et al 1990, Bakke & MacKenzie 1993, Malmberg 1993, Dalgaard et al 2003, Heinecke & Buchmann 2006, Lindenstrøm et al 2006. The response patterns of fish against gyrodactylids can be divided into 3 groups: (1) innately resistant, (2) susceptible but finally responding and (3) susceptible with no activation of responses (Bakke et al 2002).…”

Section: Introductionmentioning

confidence: 99%

“…Theoretically a series of immunological effector mechanisms (both humoral and cellular) could be involved in the response of a fish host against monogeneans (Buchmann 1999, Buchmann & Lindenstrøm 2002, but experimental evidence on this topic is limited. Lindenstrøm et al (2006) found that susceptible Scottish salmon overexpressed interleukin-1β (IL-1β)‚ in the skin during the initial phase of G. salaris infections compared to less susceptible Baltic salmon.…”

Section: Introductionmentioning

confidence: 99%

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Baltic salmon activates immune relevant genes in fin tissue when responding to Gyrodactylus salaris infection

Kania

Larsen²,

Ingerslev

et al. 2007

Dis. Aquat. Org.

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Section: Discussionsupporting

confidence: 72%

Section: Discussionmentioning

confidence: 60%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Baltic salmon activates immune relevant genes in fin tissue when responding to Gyrodactylus salaris infection

Kania

Larsen²,

Ingerslev

et al. 2007

Dis. Aquat. Org.

Self Cite

View full text Add to dashboard Cite

“…Expression of IL-8 was not detected in the latter studies. A related study (Lindenstrøm et al 2006) found elevated skin expression of IL-1β-1 in a susceptible strain of Atlantic salmon Salmo salar but not in a resistant strain 2 wk following exposure to G. salaris. These studies indicate that expression patterns of proinflammatory genes vary according to the hostparasite system.…”

Section: Discussionmentioning

confidence: 99%

Differential rejection of salmon lice by pink and chum salmon: disease consequences and expression of proinflammatory genes

Jones¹,

Fast²,

Johnson³

et al. 2007

Dis. Aquat. Org.

123

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The consequences of high (735 copepodids fish ) level exposures of size-matched juvenile pink and chum salmon to Lepeophtheirus salmonis copepodids were examined. At both levels of exposure the prevalence and abundance of L. salmonis was significantly higher on chum salmon. In addition, the weight of exposed chum salmon following the high exposure was significantly less than that of unexposed chum salmon. At both exposures, the haematocrit of exposed chum salmon was significantly less than that of unexposed chum. Neither weight nor haematocrit of pink salmon was affected by exposures at these levels. Despite the presence of microscopic inflammatory lesions associated with attachment of L. salmonis on the epithelium of gill and fin of both salmon species, there were no mortalities following either exposure. A transient cortisol response was observed in chum salmon 21 d after low exposure. An earlier and quantitatively higher expression of the proinflammatory genes interleukin-8 (IL-8), tumour necrosis factor α-1 (TNFα-1) and interleukin-1β (IL-1β) in fin and head kidney of pink salmon suggested a mechanism of more rapid louse rejection in this species. Together, these observations indicate a relatively enhanced innate resistance to L. salmonis in the juvenile pink salmon compared with the juvenile chum salmon.

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Relative quantification of immune-regulatory genes in two rainbow trout strains, Oncorhynchus mykiss, after exposure to Myxobolus cerebralis, the causative agent of whirling disease

Severin¹,

El-Matbouli²

2007

Parasitol Res

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Expression of immune-regulatory genes that code for cyclooxigenase-2 (COX-2), transforming growth factor beta (TGF-beta), and two isoforms of interleukin-1beta (IL-1beta1 and IL-1beta2) was studied in susceptible and non-susceptible rainbow trout strains for 200 days after exposure to Myxobolus cerebralis. Expression of COX-2, IL-1beta1, and IL-1beta2 increased 5 min post exposure (p.e.) and was always more elevated in the susceptible strain than in the non-susceptible strain. In both strains, expression of COX-2 returned to the control level within a few hours p.e. Expression of IL-1beta1 and IL-1beta2 showed two elevated waves in both strains until 4 days p.e. Expression of TGF-beta in the non-susceptible strain was elevated at nearly all sampling points, but was decreased in the susceptible strain until up-regulation between 4 and 20 days p.e.; TGF-beta was the only gene where the expression in the non-susceptible strain was more elevated than in the susceptible strain. Rainbow trout of the non-susceptible strain appeared to resist infection by M. cerebralis with only minor transcriptional regulation of the genes investigated. Increased transcriptions of genes in the susceptible strain may be the result of an inability to antagonize the infection.

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Skin expression of IL‐1β in East Atlantic salmon, Salmo salar L., highly susceptible to Gyrodactylus salaris infection is enhanced compared to a low susceptibility Baltic stock

Cited by 44 publications

References 22 publications

Baltic salmon activates immune relevant genes in fin tissue when responding to Gyrodactylus salaris infection

Baltic salmon activates immune relevant genes in fin tissue when responding to Gyrodactylus salaris infection

Differential rejection of salmon lice by pink and chum salmon: disease consequences and expression of proinflammatory genes

Relative quantification of immune-regulatory genes in two rainbow trout strains, Oncorhynchus mykiss, after exposure to Myxobolus cerebralis, the causative agent of whirling disease

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