Skin diseases in indigenous population: retrospective epidemiological study at Xingu Indigenous Park (<scp>XIP</scp>) and review of the literature

Wu, Jenifer Shen Ay; Florian, Marcos César; Rodrigues, Douglas; Tomimori, Jane

doi:10.1111/ijd.13716

Cited by 7 publications

(13 citation statements)

References 25 publications

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“…In two large British studies of dermatological presentations in general practice, infections represented between 6.1% and 20.3% of skin‐related consultations 5,6 . Meanwhile, a low frequency of skin cancers (0.8%) was highlighted in several Brazilian indigenous populations from the Mato Grosso State, 3 which is consistent with our results. Natural skin pigmentation can be protective against basal cell carcinoma, squamous cell carcinoma, and melanoma.…”

Section: Discussionsupporting

confidence: 90%

“…Skin infections were the main reasons for dermatological consultations in this cohort (57.6%). Similar epidemiological features were observed in the Xingu indigenous park in Brazil 3 . These results contrast with those of the European population.…”

Section: Discussionsupporting

confidence: 78%

“…Concerning parasitic infections, scabies is known to be a common disease in Amerindian populations 3 because of promiscuity and poor socioeconomic conditions. Out of 398 consultations, 36 cases (9%) of scabies were reported in the Xingu Park 3 . Similar figures were observed in our study (5%).…”

Section: Discussionmentioning

confidence: 99%

“…Differences in HLA profiles might explain a lower frequency of androgenetic alopecia than in Caucasian populations, 1 while a high frequency of actinic prurigo has been reported among Chimila Indians in Colombia 2 . Only one study in Brazil has screened the full spectrum of dermatologic diseases in such a population, reporting a high prevalence of eczemas and infectious diseases, particularly fungal and parasitic 3 . Conversely, skin cancers seemed to be less frequent than in Caucasian populations 3 .…”

Section: Introductionmentioning

confidence: 99%

“…Only one study in Brazil has screened the full spectrum of dermatologic diseases in such a population, reporting a high prevalence of eczemas and infectious diseases, particularly fungal and parasitic 3 . Conversely, skin cancers seemed to be less frequent than in Caucasian populations 3 . Due to their genetic characteristics, their isolation in remote rainforest areas, and their traditional way of life, 4 one can expect Amerindian populations living in the Amazon to suffer from a different spectrum of dermatoses than Creole and Caucasian people.…”

Section: Introductionmentioning

confidence: 99%

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Spectrum of skin diseases in Amerindian villages of the Upper Oyapock, French Guiana

et al. 2020

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Background Due to their genetic characteristics, their isolation in rainforest areas, and their traditional way of life, Amerindian populations are likely to suffer from a specific spectrum of dermatoses. However, there are few available data on such skin disorders. Our aims were to describe all skin disorders in two Amerindian villages of French Guiana. Methods This retrospective study concerned all patients who consulted in the HealthCentres of Camopi and Trois-Sauts between July 1, 2017, and December 31, 2018. We included all patients classified with an ICD code linked to a skin disorder. All medical records were cross-checked by two dermatologists to correct misclassifications.Results A total of 639 patients formed the study population, for 866 different skin disorders. Non-sexually transmitted infections represented 57.6% of all skin disorders, followed by eczema (11.5%) and bites/envenomations (9.1%). Bacteria were responsible for 238 skin infections, followed by fungi (141 cases) and parasites (69 cases, including 43 scabies, nine cutaneous leishmaniasis, and two tungiasis). We reported a low prevalence of sexually transmitted infections (10 cases) and an absence of skin cancers. ConclusionsThis study revealed the absence of skin cancer in the Amerindian population of the Upper Oyapock and the important burden of infectious and animal-related diseases. Future studies should assess a possible underestimation of sexually transmitted diseases in this area. Public health policies should target neglected diseases such as cutaneous leishmaniasis, tungiasis, scabies, and envenomations. Atopic dermatitis was a significant and unexpected cause of consultations. Dermatological conditions in the Amerindian villages of French Guiana have never been described. About 12,000 Amerindians live in this territory, divided into six different ethnic groups. Many of them live in cities where ethnic diversity makes their study difficult, and the selection of patients according to ª

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Spectrum of skin diseases in Amerindian villages of the Upper Oyapock, French Guiana

et al. 2020

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Prevalence of Oral Human Papillomavirus Infection Among Australian Indigenous Adults

et al. 2020

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IMPORTANCE Human papillomavirus (HPV) infection is associated with oropharyngeal squamous cell carcinoma. International estimates suggest overall oral HPV prevalence is 7.5%, with prevalence of oral HPV types 16 and 18 being 1.6%; prior Australian estimates suggest oral HPV prevalence is 2.3%, with HPV-16 and HPV-18 being 1.3%. OBJECTIVES To estimate the prevalence of oral HPV infection among Indigenous Australians and to report the prevalence of factors associated with high-risk HPV types (ie, HPV-16 and HPV-18) and HPV types linked with Heck disease (ie, HPV-13 and HPV-32). DESIGN, SETTING, AND PARTICIPANTS This cross-sectional study analyzed HPV screening results from saliva samples collected from 1011 Indigenous Australians between February 2018 and January 2019. Data were analyzed from May 2018 to May 2019. Recruitment occurred through Aboriginal Community Controlled Health Organisations in South Australia. Eligibility included identifying as Indigenous, residing in South Australia, and being aged 18 years or older. MAIN OUTCOMES AND MEASURES Saliva samples were collected, with microbial DNA for genotyping extracted. Sociodemographic parameters, health-related behaviors, and sexual history data were collected. Analyses were stratified by sex as well as by HPV types 13 and 32 (Heck disease) and 16 and 18 (high risk of oropharyngeal squamous cell carcinoma). Multivariable analyses were conducted to obtain adjusted odds ratios (ORs). RESULTS Data were obtained for 910 participants (median [interquartile range] age, 37 [27-51] years); 595 participants (65%) were female and 572 (63%) resided in nonmetropolitan locations. In all, 321 saliva samples (35.3%; 95% CI, 32.2%-38.4%) were positive for oral HPV (106 [33.7%] men; 215 [36.1%] women). The highest prevalence was found for HPV types 13 and 32 (207 [22.7%] total; 60 [19.0%] men; 147 [24.7%] women) followed by HPV types 16 and 18 (30 [3.3%] total; 9 [2.9%] men; 21 [3.5%] women). After multivariable analysis, risk factors associated with HPV types 13 and 32 included nonmetropolitan residential status (OR, 2.06; 95% CI, 1.10-3.88) and not having had a tonsillectomy (OR, 2.74; 95% CI, 1.05-7.16). Among women, having obtained a high school education or less was associated with lower odds of HPV-16 and HPV-18 infection (OR, 0.16; 95% CI, 0.03-0.97). CONCLUSIONS AND RELEVANCE Prevalence of oral HPV infection in a large sample of Indigenous Australians was high, with one-third testing positive. The most prevalent HPV types were those associated with Heck disease. The prevalence of HPV types associated with oropharyngeal squamous cell carcinoma exceeded both Australian and international population-level estimates.

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Cohort profile: indigenous human papillomavirus and oropharyngeal squamous cell carcinoma study - a prospective longitudinal cohort

et al. 2021

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PurposeOur aims are to: (1) estimate prevalence, incidence, clearance and persistence of oral human papillomavirus (HPV) infection among Indigenous Australians; (2) identify risk factors associated with oropharyngeal squamous cell carcinoma (OPSCC)-related HPV types (HPV 16 or 18); (3) develop HPV-related health state valuations and; (4) determine the impact on OPSCC and cervical cancers, and the cost-effectiveness of extending publicly-funded HPV vaccination among Indigenous Australians.ParticipantsParticipants were recruited from February 2018 to January 2019. Twelve-month follow-up occurred from March 2019 to March 2020. Participants provided socio-demographic characteristics, health-related behaviours including tobacco and alcohol use and sexual history. Health state preferences in regard to HPV vaccination, knowledge regarding HPV infection, OPSCC and cervical cancer were collected using a two-stage standard gamble approach. Participants provided saliva samples and DNA for microbial genotyping was extracted.Findings to dateOf the 910 participants who were positive for β-globin at baseline, 35% had any oral HPV infection. The most prevalent HPV types were 13 or 32 (Heck’s disease; 23%). The second most prevalent types were associated with OPSCC (HPV 16 or 18; 3.3%). Of the 645 participants who were positive for β-globin at 12-month follow-up, 43% had any HPV infection. Of these, 33% were HPV types 13 or 32 and 2.5% were HPV 16 or 18. Some 588 participants had β-globin positive oral samples at baseline and 12-month follow-up. The prevalence of any oral HPV infection increased from 34% at baseline to 44% at 12-month follow-up; due to increases in HPV types 13 or 32 (20% at baseline and 34% at 12-month follow-up).Future plansFurther funding will be sought to continue follow-up of this cohort, and to include (after a full medical history) a thorough clinical examination of the external head and neck; a complete oral examination and examination of the oropharynx. Blood tests for early stage OPSCC will also be undertaken.

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Skin diseases in indigenous population: retrospective epidemiological study at Xingu Indigenous Park (XIP) and review of the literature

Cited by 7 publications

References 25 publications

Spectrum of skin diseases in Amerindian villages of the Upper Oyapock, French Guiana

Spectrum of skin diseases in Amerindian villages of the Upper Oyapock, French Guiana

Prevalence of Oral Human Papillomavirus Infection Among Australian Indigenous Adults

Cohort profile: indigenous human papillomavirus and oropharyngeal squamous cell carcinoma study - a prospective longitudinal cohort

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