Skin-Derived Tenocyte-like Cells for the Treatment of Patellar Tendinopathy

Clarke, Andrew; Alyas, Faisal; Morris, Tim P.; Robertson, Claire; Bell, Jonathan; Connell, David

doi:10.1177/0363546510387095

Cited by 134 publications

(134 citation statements)

References 36 publications

Supporting

Mentioning

131

Contrasting

Unclassified

Order By: Relevance

“…30 Tenocyte transplant is a new method of treatment in tendinosis. 31 The aim is that by using skin-derived tenocytes that have been cultured in vitro, cells are placed at the site of tendinosis to help produce Type 1 and Type 2 collagen where needed. This procedure started in the equine world, has now been translated into the human population and has been used in patellar tendinopathy with some success.…”

Section: Injectable Substances and Techniquesmentioning

confidence: 99%

Ultrasound-guided intervention in the ankle and foot

Drakonaki¹,

Watura²

2016

BJR

View full text Add to dashboard Cite

Section: Injectable Substances and Techniquesmentioning

confidence: 99%

Ultrasound-guided intervention in the ankle and foot

Drakonaki¹,

Watura²

2016

BJR

View full text Add to dashboard Cite

“…Other types of stem cells including pluripotent embryonic stem cells, cord blood stem cells and fetal stem cells are currently under investigation [32]. Cells are the most important factor in wound healing [124][125][126]. It is a fact that without cells there is no healing response [1].…”

Section: Stem Cellsmentioning

confidence: 99%

“…It is a fact that without cells there is no healing response [1]. Endogenous healing cells migrate, proliferate, differentiate and produce matrix during healing process, but the role of exogenous stem cells is in doubt [120][121][122][123][124][125][126]. It has been suggested that the effectiveness of stem cells is related to their differentiation state [32].…”

Section: Stem Cellsmentioning

confidence: 99%

“…There is no well approved and comprehensive study to answer this question [12]. The results of various investigations are also contraindicated [120][121][122][123][124][125][126][127]. Some studies suggested the effectiveness of various stem cell types including differentiated and undifferentiated ones while others suggest no effectiveness [126][127][128].…”

Section: Stem Cellsmentioning

confidence: 99%

See 1 more Smart Citation

Tendon and Ligament Tissue Engineering, Healing and Regenerative Medicine

Moshiri¹,

Oryan²

2013

J Sports Med Doping Stud 2013

102

View full text Add to dashboard Cite

Tendons transmit forces from muscle to bone and provide the joint function and ligaments transmit forces from bone to bone and provide joint stability. Tendon and ligament injuries have high incidence and management of tendon and ligament injuries is technically demanding because the healing response of these soft connective tissues is low. In addition, number of the available options to be considered as tissue replacement for large defects is low and healing of tendon and ligaments is faced to significant limitations. Among the available options, autografts are still gold standard but all the auto-allo and xenografts have their own limitations. Tissue engineering is a newer option but it is still primitive to be applicable extensively, in clinical setting. Tissue engineering could be divided into four categories including scaffolds, healing promotive factors, stem cells and gene therapy. To be able to have a good judgment regarding the management of tendon and ligament injuries, it is crucial to have a basic knowledge of tendon and ligament healing and regeneration. In this review, we discussed various types of tendon and ligament injuries and their incidence, and introduced the available and future options in managing large and massive tendon and ligament injuries. We specifically discussed the tissue engineering and it's advantageous and disadvantageous. To give a better clarification for the readers, we described different phases and cascades of tendon and ligament healing, modeling and remodeling, host-graft interaction after implantation of the graft and various types of prosthetic implants and finally provided some suggestions for the future investigations.

show abstract

“…To date, only 5 clinical studies of cell based therapy in tendons have been reported (Table 6). Of the five human studies reported, only one was randomized control trial, which showed the skin-derived tenocyte-like cells has a better potential than the autologous plasma to improve pain and function in patellar tendinopathy (63). Cohort studies showed that the bone marrow-derived mononuclear cells (64) and skin derived tenocyte-like cells (65) have a potential to improve rotator cuff tear and in lateral epicondylitis respectively.…”

Section: Surgical Repair and Cell Based Therapy In Tendon Healingmentioning

confidence: 99%

A MINI REVIEW ON THE BASIC KNOWLEDGE ON TENDON: REVISITING THE NORMAL & INJURED TENDON

Tan

Selvaratnam²,

Ahmad

2015

JUMMEC

View full text Add to dashboard Cite

Tendon is a dense connective tissue that connects muscle to bone. Tendon can adapt to mechanical forces passing across it, through a reciprocal relationship between its cellular components (tenocytes and tenoblasts) and the extracellular matrix (ECM). In early development, the formation of scleraxis-expressing tendon progenitor population in the sclerotome is induced by a fibroblast growth factor signal secreted by the myotome. Tendon injury has been defined as a loss of cells or ECM caused by trauma. It represents a failure of cells and matrix adaptation to mechanical loading. Injury initiates attempts of tendon to repair itself, which has been defined as replacement of damaged or lost cells and ECM by new cells or new matrices. Tendon healing generally consists of four different phases: the inflammatory, proliferation, differentiation and remodelling phases. Clinically, tendons are repaired with a variety of surgical techniques, which show various degrees of success. In order to improve the conventional tendon repair methods, current tendon tissue engineering aims to investigate a repair method which can restore tissue defects with living cells, or cell based therapy. Advances in tissue engineering techniques would potentially yield to a cell-based product that could regenerate functional tendon tissue.

show abstract

Skin-Derived Tenocyte-like Cells for the Treatment of Patellar Tendinopathy

Abstract: Ultrasound-guided injection of autologous skin-derived tendon-like cells can be safely used in the short term to treat patellar tendinopathy, with faster response of treatment and significantly greater improvement in pain and function than with plasma alone.

Cited by 134 publications

References 36 publications

Ultrasound-guided intervention in the ankle and foot

Ultrasound-guided intervention in the ankle and foot

Tendon and Ligament Tissue Engineering, Healing and Regenerative Medicine

A MINI REVIEW ON THE BASIC KNOWLEDGE ON TENDON: REVISITING THE NORMAL & INJURED TENDON

Contact Info

Product

Resources

About