Skin depigmentation activity of &lt;i&gt;Crocus sativus&lt;/i&gt; extract cream

Aktar, N; Khan, HMS; Ashraf, Shoaib; Mohammad, IS; Ali, Ayesha

doi:10.4314/tjpr.v13i11.5

Cited by 8 publications

(7 citation statements)

References 10 publications

(3 reference statements)

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“…Then, the oily phase was poured into aqueous phase drop by drop with continuous stirring at 2000 rpm by the mechanical stirrer for 15 min until complete oily phase was added. The speed of mechanical stirrer was then adjusted to 1000 rpm for 5 minutes and further decreased to 500 rpm for next 5 minutes 11 . Base and test formulations were prepared in the same way; the only difference was addition of Albizia lebbeck bark extract in test formulation.…”

Section: Methodsmentioning

confidence: 99%

Development and cosmeceutical evaluation of topical emulgel containing Albizialebbeck bark extract

Tasneem

Khan

Zaka

et al. 2021

J of Cosmetic Dermatology

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Background Antioxidants are widely used in cosmetic products as they have beneficial effects on skin and prevent skin from harmful effects of environment. Albizia lebbeck has a significant potential to be used in cosmeceuticals due to its antioxidant activity. Objectives The aim of this study was to formulate a stable and effective o/w emulsion‐based emulgel containing Albizia lebbeck bark extract, which have considerable antioxidant activity. Methodology Antioxidant activity of Albizia lebbeck bark extract was determined by DPPH (2,2‐diphenyl‐1‐picrylhydrazyl) method. Emulgel containing 3% extract was developed by mixing o/w emulsion in Carbopol gel along with a placebo emulgel without extract (base). In vitro evaluation of these emulgels, that is, liquefaction, color, phase separation, centrifugation, and pH change were carried out for a period of 8 weeks at different storage conditions, that is, 8ºC, 25ºC, 40ºC, and 40ºC & 75% relative humidity (RH). In vivo evaluation of emulgels was carried out on 13 healthy female volunteers by measuring various parameters of skin, that is, melanin level, erythema level, moisture content, sebum content, and elasticity at regular time intervals after applying emulgel (both base and test formulation) for 8 weeks. Results Antioxidant activity of Albizia lebbeck bark extract was 84.7%. Both emulgels (base and test formulation) were stable at all storage conditions. Statistical analysis showed that test formulation produced significant effects (p < 0.05) on melanin, erythema level, moisture content, sebum level, and elasticity of skin. Conclusion It can be concluded that a stable topical emulgel containing 3% Albizia lebbeck bark extract has significant antioxidant effects on human skin.

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Section: Methodsmentioning

confidence: 99%

Development and cosmeceutical evaluation of topical emulgel containing Albizialebbeck bark extract

Tasneem

Khan

Zaka

et al. 2021

J of Cosmetic Dermatology

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“…Saffron cream has been reported to exhibit significant depigmentation effect in a study done by Akhtar et al. (2014) .…”

Section: Safranal In Skin Photoagingmentioning

confidence: 98%

“…Saffron cream has been reported to exhibit significant depigmentation effect in a study done by Akhtar et al (2014). Dried stigma was extracted using maceration and this extract was used to formulate a cream.…”

Section: Safranal In Skin Photoagingmentioning

confidence: 99%

The role of Safranal and saffron stigma extracts in oxidative stress, diseases and photoaging: A systematic review

Nanda

Madan

2021

Heliyon

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Reactive oxygen species (ROS) are produced as a result of various environmental factors and cellular metabolism reactions creating oxidative stress. The reversible oxidative modification on proteins such as cysteine oxidation may be useful and can play positive role. ROS generated offer some benefits such as cellular signalling and tissue repair when present in low concentration. However, most of the times, these reactive species cause detrimental effects to cell components which leads to various pathological conditions which causes or aggravates diseases due to oxidative stress. The degenerative diseases due to oxidative stress are diabetes, cardiovascular diseases, epilepsy, cancer and aging. Antioxidants are the compounds which scavenge these free radicals and hence neutralize their effects. Research has enabled the use of natural antioxidants as therapeutic agent in the treatment of diseases. Safranal is one such natural agent which is a major volatile component of saffron. Saffron, Red gold is the most expensive spice found in limited region of the planet and is also reported to be used in traditional systems of medicine. Chemically, safranal is a monoterpene aldehyde possessing a sweet fragrance. While exploring for the photoprotective properties of safranal, we learnt about the immense antioxidant potential of safranal. Investigation by various research groups established safranal as an anti-inflammatory, antidepressant, anxiolytic, antiasthamatic, antihypertensive, anticonvulsant, anticancer and antitussive and antigenotoxic agent. It has brought researchers over the world to explore the antioxidant benefits of saffron for human health. In the present paper, potential of safranal and its related molecules as radical scavenger in combating oxidative stress, diseased conditions is collated and the underlying mechanisms have been explained. Various cell lines and animal models used for study of Safranal have been discussed.

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“…1,5,8 Crocin showed high radical scavenging activity (50% in 500 ppm methanol solution and 65% and 1000 ppm methanol solution) followed by safranal which was 34% in 500 ppm methanol solution. 2,6 Fagot et al who conducted regarding the evaluation of antioxidant activity in saffron, found that crocin has very strong antioxidant activity compared to vitamin E and vitamin C. 8,17,18 Deng et al research on in vitro human fibroblasts used crocin to assess crocin activity in preventing photoaging where crocin was shown to reduce intracellular ROS levels by neutralizing ROS formed through its dose-dependent inhibitory activity, increasing cell cycle repair, and cell proliferation, increased extracellular matrix activity, and preventing apoptosis. 8 Crocin can inhibit UVAinduced cell membrane peroxidation and inhibit the expression of various proinflammatory mediators including IL-8, PGE-2, IL-6, TNF-α, IL-1 α, and Leukotriene B4 (LTB 4).…”

Section: Antioxidant Activitymentioning

confidence: 99%

Literature Review: The Role of Saffron (Crocus sativus L) in Cosmetic Dermatology

Damayanti,

Riyanto

2023

dmj

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Background : Crocus sativus L known as saffron is widely discussed in Indonesia. Although saffron has been used since ancient times for medicinal and cosmetic purposes, scientific research on the mechanism of saffron in its role in promoting skin health is lacking. Objectives : This literature review is to determine the role of saffron in cosmetic dermatology. Methods : This article is a narrative research. The library sources that used was carried out through the database Google Scholar, PubMed, and Cochrane. The article search does not limit study design or study level. All articles were searched from 2012 to June 2023. The study inclusion criteria included: data available in English and Indonesian. Exclusion criteria were articles on the benefits of using saffron in the other field of dermatology and the use of saffron in combination with other topical active ingredients. Results : There were 16 articles which meet the criterias. It was found that saffron play role in the cosmetic dermatology such as in skin aging, melasma, as a photoprotection agents, skin moisturizer, prevention and treatment of skin cancer, as well as preparation of cosmetic products. Saffron has antioxidant, antiinflammatory, antipigmentation, antiwrinkle, anticarcinogenic and photoprotective activities. Conclusion : Crocus sativus L is a natural ingredient that has the potential to be further developed into medicinal forms, both oral and topical preparations because it is proven to have various pharmacological effects that play role in the cosmetic dermatology.

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Skin depigmentation activity of <i>Crocus sativus</i> extract cream

Cited by 8 publications

References 10 publications

Development and cosmeceutical evaluation of topical emulgel containing Albizialebbeck bark extract

Development and cosmeceutical evaluation of topical emulgel containing Albizialebbeck bark extract

The role of Safranal and saffron stigma extracts in oxidative stress, diseases and photoaging: A systematic review

Literature Review: The Role of Saffron (Crocus sativus L) in Cosmetic Dermatology

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