Skin Denervation and Cutaneous Vasculitis in Eosinophilia-Associated Neuropathy

Abstract

Background: Eosinophilia is frequently associated with peripheral neuropathy, and neuropathic pain is a major presentation. Little is known about the involvement of sensory nerve terminals and the vasculature in the skin of patients with eosinophilia. Objectives: To investigate the skin innervation and the pathological abnormalities of the cutaneous vasculature and their clinical significance in eosinophilia-associated neuropathy.

Eosinophils in Autoimmune Diseases

“…These eosinophils are degranulating and cytotoxic to nerves (209, 210). Sometimes eosinophils form part of the inflammatory infiltrate surrounding necrotizing vessels (209, 211, 212). This may accelerate damage of blood vessels because eosinophils were shown to be directly cytotoxic to endothelial cells in vitro (34, 213).…”

Skin biopsy: an emerging method for small nerve fiber evaluation

“…5,10,[16][17][18][19][20][21] Several studies recently applied IENFD quantification in axonal neuropathy, vasculitic neuropathy, and hereditary neuropathy. [22][23][24] Comparison the IENFD of symptomatic side with that of symmetric healthy side is a useful way to diagnose asymmetric or focal neuropathy. 25 Skin biopsy is a minimally invasive method and repeated biopsy causes no complication.…”

Clinical and diagnostic features of small fiber damage in diabetic polyneuropathy

“…However, no change was observed in 18 diabetic patients after pancreas/kidney transplantation (SPK) (Boucek et al, 2008). Several recent studies have also shown a significant reduction in IENFD in high fat fed mice with moderate hyperglycemia (Chao et al, 2007b;Vincent et al, 2009). These data suggest that IENF loss is an early feature of diabetes, progresses with increasing neuropathic severity, and may improve with appropriate intervention.…”