Skin Delivery Aspects of Benzoyl Peroxide-Loaded Solid Lipid Nanoparticles for Acne Treatment

Pokharkar, Varsha; Mendiratta, Charu; Kyadarkunte, Abhay; Bhosale, S.H.; Barhate, Ganesh

doi:10.4155/tde.14.31

Cited by 30 publications

(13 citation statements)

References 40 publications

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“…21 Benzoyl peroxide-loaded SLN showed a higher drug deposition in skin organelles, lower skin irritation, sustained drug release, lower drug absorption to the systemic circulation, and reduced adverse effects in comparison with available marketed formulations. 23 Lipid nanoparticles are promising carriers for the topical delivery of lipophilic drugs with high log P values (log P>3) and large molecular weights. Because of their lipidic nature, SLNs have higher entrapment efficiency and penetrate deeply through skin layers.…”

Section: Solid Lipid Nanoparticles (Slns)mentioning

confidence: 99%

<p>Potential of Nanoparticles as Permeation Enhancers and Targeted Delivery Options for Skin: Advantages and Disadvantages</p>

Ghasemiyeh

Mohammadi-Samani

2020

DDDT

188

113

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The topical route of administration has many advantages for the treatment of various skin disorders as well as cosmeceutical purposes. This route bypasses hepatic firstpass effect and systemic availability of many pharmaceuticals is limited to skin organelles such as hair follicles and so could avoid unwanted adverse reactions and increase the localized therapeutic effect. Despite such attributed advantages of the topical route, the most important challenge is skin barrier characteristics that should be overcome to obtain dermal or trans-dermal drug delivery. Different approaches have been recruited to overcome this barrier. In this review, different types of nanoparticles for skin permeation enhancement and targeted delivery to skin organelles are discussed. The potential mechanisms of each nanocarrier in permeation enhancement and dermal delivery are considered and finally, the most important advantages and disadvantages of each group are summarized.

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Section: Solid Lipid Nanoparticles (Slns)mentioning

confidence: 99%

<p>Potential of Nanoparticles as Permeation Enhancers and Targeted Delivery Options for Skin: Advantages and Disadvantages</p>

Ghasemiyeh

Mohammadi-Samani

2020

DDDT

188

113

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“…The optimized SLN (F4) was successfully incorporated into the carbopol-based hydrogel. The comparison in vitro release of ERY from the SLN gel showed 90.94% and plain gel showed 87.94% .Therefore concluding that In vitro study of ERY-loaded SLN gel showed sustained delivery of drug from formulation thus enhancing the antimicrobial activity after 30 hours when compared to ERY plain gel (20).…”

Section: Solid Lipid Nanoparticles Slnmentioning

confidence: 77%

Recent advances for commedonal acne treatment by employing lipid nanocarriers topically

Patnaik

Purohit

Biswasroy

et al. 2022

ijhs

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Acne is one of the most common chronic inflammatory dermatological disorder associated with multifactorial pathogenesis. Approximately 95 % of the population suffers from it at some point in their lifetime. Antibiotics, acids, benzoyl peroxide, and retinoids are the most commonly drugs used for the treatment of acne. However, conventional formulations of these drugs are associated with undesirable toxicities, inadequate penetration across stratum corneum, short retention time of the drug in the target site, and poor aqueous solubility of drugs, that limited their medicinal applications. As a consequence pharmaceutical researchers are turning towards novel drug delivery systems to overcome these limitations.With respect to their small particle size, lipid occlusive nature and unique surface characteristics, lipid nanocarriers can promote skin hydration, enhance drug permeation, improve its targeting properties and retention time on the skin, increase drug solubility and protect it from degradation, provide sustained drug release and reduce dosing frequency. The current review summarizes the better nanotechnological systems that can be used in future for better and effective treatment of acne.

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“…It has been demonstrated that reducing the drug particle size to the nanometer range in diameter using SLNs provides effective ocular tissue penetration and resolution of pain and inflammation despite a reduced drug concentration (0.38%) and dosing frequency (Salinger et al, 2019). Benzoyl peroxide SLN has demonstrated higher drug accumulation in lower skin inflammation, skin organelles, continuous release of drugs, lower systemic absorption of drugs, and decreased adverse effects relative to the current marketing formulations (Pokharkar et al, 2014). Lipid NPs are significant carriers for lipophilic drugs for topical delivery having high log P-values (logP > 3) and maximum molecular weight (≤500).…”

Section: Solid Lipid Nanoparticles (Slns)mentioning

confidence: 99%

Enhancing Permeation of Drug Molecules Across the Skin via Delivery in Nanocarriers: Novel Strategies for Effective Transdermal Applications

Yang

et al. 2021

Front. Bioeng. Biotechnol.

182

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The transdermal route of administration provides numerous advantages over conventional routes i.e., oral or injectable for the treatment of different diseases and cosmetics applications. The skin also works as a reservoir, thus deliver the penetrated drug for more extended periods in a sustained manner. It reduces toxicity and local irritation due to multiple sites for absorption and owes the option of avoiding systemic side effects. However, the transdermal route of delivery for many drugs is limited since very few drugs can be delivered at a viable rate using this route. The stratum corneum of skin works as an effective barrier, limiting most drugs’ penetration posing difficulty to cross through the skin. Fortunately, some non-invasive methods can significantly enhance the penetration of drugs through this barrier. The use of nanocarriers for increasing the range of available drugs for the transdermal delivery has emerged as a valuable and exciting alternative. Both the lipophilic and hydrophilic drugs can be delivered via a range of nanocarriers through the stratum corneum with the possibility of having local or systemic effects to treat various diseases. In this review, the skin structure and major obstacle for transdermal drug delivery, different nanocarriers used for transdermal delivery, i.e., nanoparticles, ethosomes, dendrimers, liposomes, etc., have been discussed. Some recent examples of the combination of nanocarrier and physical methods, including iontophoresis, ultrasound, laser, and microneedles, have also been discussed for improving the therapeutic efficacy of transdermal drugs. Limitations and future perspectives of nanocarriers for transdermal drug delivery have been summarized at the end of this manuscript.

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Skin Delivery Aspects of Benzoyl Peroxide-Loaded Solid Lipid Nanoparticles for Acne Treatment

Abstract: Desired goals were achieved by factorial design approach in shortest possible time with minimum number of experiments. The developed BPO-SLN system provided controlled drug release, thereby reducing the well-known side effects.

Cited by 30 publications

References 40 publications

<p>Potential of Nanoparticles as Permeation Enhancers and Targeted Delivery Options for Skin: Advantages and Disadvantages</p>

<p>Potential of Nanoparticles as Permeation Enhancers and Targeted Delivery Options for Skin: Advantages and Disadvantages</p>

Recent advances for commedonal acne treatment by employing lipid nanocarriers topically

Enhancing Permeation of Drug Molecules Across the Skin via Delivery in Nanocarriers: Novel Strategies for Effective Transdermal Applications

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