Skin conductance measurement for the assessment of analgosedation adequacy in infants treated with mechanical ventilation: A multicenter pilot study

Walas, Wojciech; Halaba, Zenon; Kubiaczyk, Agata; Piotrowski, Andrzej; Latka-Grot, Julita; Szczapa, Tomasz; Romul, Monika; Maroszyńska, Iwona; Malinowska, Ewelina; Rutkowska, Magdalena; Skrzypek, Michał; Śmigiel, Robert

doi:10.17219/acem/126286

Cited by 5 publications

(4 citation statements)

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“…Skin conductance responses to painful procedures can be observed in neonates receiving analgesia or sedation ( 65 ), but are obliterated by neuromuscular blockade ( 68 ). Moreover, skin conductance responses (increased number of peaks per second) have been observed during persistent pain or stress, as experienced postoperatively and during mechanical ventilation ( 69 – 72 ), and a cutoff value of 0.1 fluctuations of skin conductance per second enabled discrimination between pain requiring urgent attention and well-controlled pain in postoperative children ( 69 – 71 ).…”

Section: Monitoring- and Response-biomarkersmentioning

confidence: 99%

Biomarkers for assessing pain and pain relief in the neonatal intensive care unit

ten Barge,

Baudat,

Meesters

et al. 2024

Front. Pain Res.

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Newborns admitted to the neonatal intensive care unit (NICU) regularly undergo painful procedures and may face various painful conditions such as postoperative pain. Optimal management of pain in these vulnerable preterm and term born neonates is crucial to ensure their comfort and prevent negative consequences of neonatal pain. This entails accurate and timely identification of pain, non-pharmacological pain treatment and if needed administration of analgesic therapy, evaluation of treatment effectiveness, and monitoring of adverse effects. Despite the widely recognized importance of pain management, pain assessment in neonates has thus far proven to be a challenge. As self-report, the gold standard for pain assessment, is not possible in neonates, other methods are needed. Several observational pain scales have been developed, but these often rely on snapshot and largely subjective observations and may fail to capture pain in certain conditions. Incorporation of biomarkers alongside observational pain scores holds promise in enhancing pain assessment and, by extension, optimizing pain treatment and neonatal outcomes. This review explores the possibilities of integrating biomarkers in pain assessment in the NICU.

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Section: Monitoring- and Response-biomarkersmentioning

confidence: 99%

Biomarkers for assessing pain and pain relief in the neonatal intensive care unit

ten Barge,

Baudat,

Meesters

et al. 2024

Front. Pain Res.

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“…Redd et al (2020); Shao et al (2020) and Weyn et al (2022) included elementary school students in their research. One study included neonates on mechanical ventilation (Walas et al, 2020). 5.4% of the studies, realised by Melander et al (2017) another 2.7% included subjects with a substance use disorder (Carreiro et al, 2020;Alinia et al, 2021).…”

Section: Study Populationmentioning

confidence: 99%

“…The wristbands DTI2 (Melander et al, 2017) and Empatica E4 (Deutsch et al, 2021;Iaboni et al, 2022) were used in clinical settings with patients with dementia. Additionally, Lai Kwan et al (2019) (Betancourt et al, 2017;Baker et al, 2018;Goodwin et al, 2019;Redd et al, 2020;Weyn et al, 2022), fingers (Shao et al, 2020), palm (Walas et al, 2020) and ankle (Betancourt et al, 2017).…”

Section: Wearablesmentioning

confidence: 99%

Wearables measuring electrodermal activity to assess perceived stress in care: a scoping review

Klimek

Mannheim

Schouten

et al. 2023

Acta Neuropsychiatr.

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Background: Chronic stress responses can lead to physical and behavioural health problems, often experienced and observed in the care of people with intellectual disabilities or people with dementia. Electrodermal activity (EDA) is a bio-signal for stress, which can be measured by wearables and thereby support stress management. However, the how, when and to what extent patients and healthcare providers can benefit, is unclear. This study aims to create an overview of available wearables enabling the detection of perceived stress by using EDA. Methods: Following the PRISMA-SCR protocol for scoping reviews, four databases were included in the search of peer-reviewed studies published between 2012-2022, reporting detection of EDA in relation to self-reported stress or stress-related behaviours. Type of wearable, bodily location, research population, context, stressor type and the reported relationship between EDA and perceived stress were extracted. Results: Of the 74 included studies, the majority included healthy subjects in laboratory situations. Field studies and studies using machine learning to predict stress have increased in the last years. EDA is most often measured on the wrist, with offline data processing. Studies predicting perceived stress or stress-related behaviour using EDA features, reported accuracies between 42%-100% with an average of 82.6%. Of these studies, the majority used machine learning. Conclusion: Wearable EDA sensors are promising in detecting perceived stress. Field studies with relevant populations in a health or care context are lacking. Future studies should focus on the application of EDA-measuring wearables in real-life situations to support stress management.

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“…Changes in electrical skin conductance measured on the palmar side of the hands and soles appear suitable for objective pain evaluation [23,24]. The activation of the sympathetic nervous system by painful stimuli leads to the activation of eccrine sweat glands and an increase in electrical skin conductivity.…”

Section: Skin Conductance Measurement (Scm)mentioning

confidence: 99%

Multimodal Pain Management in Extremely Low Birth Weight Neonates after Major Abdominal Surgery

Jancova,

Pokorna

2023

Topics in Postoperative Pain

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Limited data are available in the literature on multimodal pain management in extremely low birth weight (ELBW) neonates. This chapter aimed to summarize current knowledge about the effects of analgesics and sedatives (paracetamol, opioids, benzodiazepines and anaesthetics) on postoperative pain management (≤ 48 hours after surgery). The primary endpoints of postoperative pain management were searched using validated pain assessment instruments, such as pain intensity, excessive sedation, drug consumption or adequate rescue medication. The secondary endpoints are the safety parameters of the drugs used, while the determinants of short/long-term outcome (duration of mechanical ventilation, intraventricular haemorrhage—IVH, periventricular leukomalacia—PVL, postnatal growth restriction, stage of chronic lung disease—CLD or neurodevelopmental outcome according to the Bayley-II Scale of Infant Development at 18–24 months or developmental equivalents at early-school age) were assessed as tertiary endpoints. Additionally, one of the most important key elements of clinical science is known as clinical research study validation, including specific tools and techniques within the validation processes. This chapter focuses on postoperative multimodal pain management, including the implementation of pain assessment tools and analgesic and sedative dosing regimens needed to achieve the efficacy and safety goals of an optimal pain profile in ELBW neonates; only proven non-pharmacological procedures are not included.

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Skin conductance measurement for the assessment of analgosedation adequacy in infants treated with mechanical ventilation: A multicenter pilot study

Cited by 5 publications

References 0 publications

Biomarkers for assessing pain and pain relief in the neonatal intensive care unit

Biomarkers for assessing pain and pain relief in the neonatal intensive care unit

Wearables measuring electrodermal activity to assess perceived stress in care: a scoping review

Multimodal Pain Management in Extremely Low Birth Weight Neonates after Major Abdominal Surgery

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