Skin colour data from Nowshahr City, Northern Iran

Mehrai, Haideh; Sunderland, E.

doi:10.1080/03014469000000862

Cited by 26 publications

(8 citation statements)

References 7 publications

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“…Yet, within individual ethnic groups, men have been reported to have darker and less reflective complexions [30][31][32]. It has been suggested that this is the consequence of men having a more vascularized upper dermis [26] and more melanin [33,34]. These differences could have hormonal causes because they arise during puberty and also increase with age [35].…”

Section: Skin Tonementioning

confidence: 98%

Gender-linked differences in human skin

Giacomoni

Mammone

Teri

2009

Journal of Dermatological Science

230

185

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Section: Skin Tonementioning

confidence: 98%

Gender-linked differences in human skin

Giacomoni

Mammone

Teri

2009

Journal of Dermatological Science

230

185

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“…A large proportion of inhabitants of Ardabil are Azeri (also of Caucasian ancestry). The average skin pigmentation of people living in these provinces is light, showing affinities with less pigmented populations residing in neighboring countries to the West of Iran (Mehrai and Sunderland, 1990). The province of Kerman is located in southeastern Iran with dry moderate climate in the north of the province and warm and humid in the south.…”

Section: Discussionmentioning

confidence: 99%

Incidence of cutaneous malignant melanoma in Iranian provinces and American states matched on ultraviolet radiation exposure: an ecologic study

Moslehi

Zeinomar

Boscoe

2018

Environmental Pollution

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Objectives Ultraviolet radiation (UVR), with UVB and UVA as the relevant components, is a risk factor for melanoma. Complete ascertainment and registration of melanoma in Iran was conducted in five provinces (Ardabil, Golestan, Mazandaran, Gilan and Kerman) during 1996–2000. The aim of our study was to compare population-based incidence data from these provinces with rates in the United States (US) while standardizing ambient UVR. Methods Population-based rates representing all incident cases of melanoma (1996–2000) across the five Iranian provinces were compared to rates of melanoma among white non-Hispanics in the US. Overall age-standardized rates (ASR) for Iran and the US (per 100,000 person-years adjusted to 2000 world population) and standardized rate ratios (SRR) were calculated. We measured erythemally-weighted average solar UVR exposures (with contributions from both UVB and UVA range) of the five Iranian provinces using data from NASA's Total Ozone Mapping Spectrometer and selected five US states (Kentucky, Utah, Texas, Oklahoma, and Hawaii) with matching UVR exposure to each province. Incidence rates of melanoma during 1996–2000 in each Iranian province were compared to rates among white non-Hispanics in its UVR-matched US state. Results The overall male and female ASRs of melanoma were 0.60 (95%CI: 0.56–0.64) and 0.46 (95%CI: 0.42–0.49), respectively, for Iran and 22.78 (95%CI: 22.42–23.14) and 16.61 (95%CI: 16.30–16.92) for the US. SRRs of melanoma comparing US to Iran were 37.97 (95%CI: 35.78–40.29) for males and 36.11 (95%CI: 33.69–38.70) for females, indicating significantly higher incidence in the US. ASRs and age-specific rates of melanoma for both genders were significantly lower in each Iranian province compared to its UVR-matched US state. Conclusion The markedly lower incidence rates of melanoma in Iranian provinces with similar UVR exposures to US states underscore the need for additional comparative studies to decipher the influence of other extrinsic and intrinsic factors on the risk of this malignancy.

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“…Sexual dimorphism in skin color has been reported, with females tending to have lighter skin color than males after puberty (Cartwright, 1975; Clark et al, 1981; Jaswal, 1983; Frost, 1988; Mehrai and Sunderland, 1990; Williams-Blangero and Blangero, 1991). Lightening of skin color is reported to occur during puberty in both sexes, but the process is less noticeable in males, so that females are lighter than males in adulthood (Mesa, 1983).…”

Section: Discussionmentioning

confidence: 99%

Gene mapping study for constitutive skin color in an isolated Mongolian population

et al. 2012

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To elucidate the genes responsible for constitutive human skin color, we measured the extent of skin pigmentation in the buttock, representative of lifelong non-sun-exposed skin, and conducted a gene mapping study on skin color in an isolated Mongolian population composed of 344 individuals from 59 families who lived in Dashbalbar, Mongolia. The heritability of constitutive skin color was 0.82, indicating significant genetic association on this trait. Through the linkage analysis using 1,039 short tandem repeat (STR) microsatellite markers, we identified a novel genomic region regulating constitutive skin color on 11q24.2 with an logarithm of odds (LOD) score of 3.39. In addition, we also found other candidate regions on 17q23.2, 6q25.1, and 13q33.2 (LOD ≥ 2). Family-based association tests on these regions with suggestive linkage peaks revealed ten and two significant single nucleotide polymorphisms (SNPs) on the linkage regions of chromosome 11 and 17, respectively. We were able to discover four possible candidate genes that would be implicated to regulate human skin color: ETS1, UBASH3B, ASAM, and CLTC.

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Skin colour data from Nowshahr City, Northern Iran

Cited by 26 publications

References 7 publications

Gender-linked differences in human skin

Gender-linked differences in human skin

Incidence of cutaneous malignant melanoma in Iranian provinces and American states matched on ultraviolet radiation exposure: an ecologic study

Gene mapping study for constitutive skin color in an isolated Mongolian population

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