A variety of clinical phenotypes are observed in dermatological illnesses, which can occasionally make diagnosis challenging. Our study aimed to conduct a retrospective analysis of dermatopathological correlation and highlight its significance in establishing an accurate diagnosis. Retrospective analysis was done on histopathological data gathered from a tertiary health care centre over a period of 18 months. To facilitate analysis, the results were categorised into various groups. Of the 336 cases that were examined in total, microbial infections accounted for the majority (33.93%, n = 114/336). Non-infectious erythematous papular and squamous disease (18.75% n = 63/336) and non-infectious vesiculobullous and vesicopustular disease (11.31% n = 38/336) were the other two prevalent groups. The least common categories were inflammatory disease of subcutis (0.3% n = 1/336) and disorder associated with physical agent (0.3% n = 1/336). The histological results were generally in agreement with the clinical observations (75.60 percent, n = 253/336). Partial concordance and discordance was seen in 10.12% (34/336) and 6.25% (21/336) cases respectively. Early histopathological diagnosis and clinicopathological correlation helped in timely management of partially concordant and discordant cases. This study highlights the value of skin biopsies as an easy, reasonably priced, and useful tool in a dermatologist's toolbox. Histopathological analysis distinguishes between illnesses with similar morphologies, hence preventing misdiagnosis. Histopathology was useful in diagnosing a number of neoplastic disorders and in determining the progression or resolution of diseases like leprosy. Discordant cases were timely managed with the help of histopathological and clinical correlation.