Skin Collagen Reduction Drives Selective Aspects of Aging in Sensory Neurons
Meera M. Krishna,
Ariel L. Franitza,
Lezi E
Abstract:Despite significant progress in understanding the molecular processes of aging-associated neurodegeneration, the upstream mechanisms driving neuronal aging remain elusive. Here, we investigate the potential regulatory roles of non-neural tissues in neuronal aging, using Caenorhabditis elegans PVD polymodal neuron as a model. We find that cutaneous PVD neurons develop progressive excessive dendritic branching during normal aging, functionally correlated with age-related deficits in proprioception. Our study rev… Show more
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