Skin collagen allografts in the rat

Oliver, R. F.; Hulme, M. J.; Mudie, A.; Grant, R. A.

doi:10.1038/258537a0

Cited by 30 publications

(7 citation statements)

References 6 publications

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“…These results are consistent with previous reports of acellular dermal scaffolds exhibiting a lack of long term inflammation when implanted subcutaneously; and GA crosslinked scaffolds exhibiting a slight response [ 28–31 ]. The reported amount of degradation in decellularized ECM scaffolds also varies greatly, with complete degradation occurring in scaffolds without crosslinking in 50 days and 0–15% degradation in glutaraldehyde crosslinked [ 24 , 31 ], some absorption after 20 weeks for Permacol scaffolds [ 32 ], and 28 days for Alloderm [ 33 ].…”

Section: Discussionsupporting

confidence: 93%

Biocompatibility and degradation of tendon-derived scaffolds

Alberti

2015

Regen Biomater

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Decellularized extracellular matrix has often been used as a biomaterial for tissue engineering applications. Its function, once implanted can be crucial to determining whether a tissue engineered construct will be successful, both in terms of how the material breaks down, and how the body reacts to the material’s presence in the first place. Collagen is one of the primary components of extracellular matrix and has been used for a number of biomedical applications. Scaffolds comprised of highly aligned collagen fibrils can be fabricated directly from decellularized tendon using a slicing, stacking, and rolling technique, to create two- and three-dimensional constructs. Here, the degradation characteristics of the material are evaluated in vitro, showing that chemical crosslinking can reduce degradation while maintaining fiber structure. In vivo, non-crosslinked and crosslinked samples are implanted, and their biological response and degradation evaluated through histological sectioning, trichrome staining, and immunohistochemical staining for macrophages. Non-crosslinked samples are rapidly degraded and lose fiber morphology while crosslinked samples retain both macroscopic structure as well as fiber orientation. The cellular response of both materials is also investigated. The in vivo response demonstrates that the decellularized tendon material is biocompatible, biodegradable and can be crosslinked to maintain surface features for extended periods of time in vivo. This study provides material characteristics for the use of decellularized tendon as biomaterial for tissue engineering.

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Section: Discussionsupporting

confidence: 93%

Biocompatibility and degradation of tendon-derived scaffolds

Alberti

2015

Regen Biomater

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“…Pelvicol-implanted mice display a decreased and shorter lasting in¢ltration of PMN with a predominant Mo/Ma population in the in¢ltrate. These observations are also in concordance with experimental data using other porcine dermal collagen implants [Oliver et al, 1975;Oliver et al, 1982;Livesey et al, 1995] and clinical studies with Pelvicol [Arunkalaivanan and Barrington, 2003;Salomon et al, 2004].…”

Section: Discussionsupporting

confidence: 89%

Cytokine production following experimental implantation of xenogenic dermal collagen and polypropylene grafts in mice

Zheng

Luo

Verbiest

et al. 2006

Neurourology and Urodynamics

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“…In 1975, Oliver and colleagues demonstrated that cross-linking porcine tissues protected the biomaterial from biodegradation, prolonging their permanence following implantation [60]. Tissue Sciences Laboratories employs a cross-linking method in their preservation/processing of Permacol.…”

Section: Degradationmentioning

confidence: 98%

Abdominal wall reconstruction using biological tissue grafts: present status and future opportunities

Bellows¹,

Alder

Helton³

2006

Expert Review of Medical Devices

100

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Surgeons often encounter the challenge of treating acquired abdominal wall defects following abdominal surgery. The current standard of practice is to repair most defects using permanent synthetic mesh material. Mesh augments the strength of the weakened abdominal wall fascia and enables the hernia repair to be performed in a tension-free manner. However, there is a risk of acute and/or chronic infection, fistula formation and chronic abdominal wall pain with the use of permanent mesh materials, which can lead to more complex operations. As a means to avoid such problems, surgeons are turning increasingly to the use of xenogenic and allogenic materials for the repair of abdominal wall defects. Their rapid evolution and introduction into the clinical operating room is leading to a new era in abdominal wall reconstruction. There are promising, albeit limited, clinical data with short-term follow-up for only a few of the many biological tissue grafts that are being promoted currently for the repair of abdominal hernias. Additional clinical studies are required to better understand the long-term efficacy and limitations of these materials.

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Skin collagen allografts in the rat

Cited by 30 publications

References 6 publications

Biocompatibility and degradation of tendon-derived scaffolds

Biocompatibility and degradation of tendon-derived scaffolds

Cytokine production following experimental implantation of xenogenic dermal collagen and polypropylene grafts in mice

Abdominal wall reconstruction using biological tissue grafts: present status and future opportunities

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