2015
DOI: 10.1186/s12933-015-0266-4
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Skin collagen advanced glycation endproducts (AGEs) and the long-term progression of sub-clinical cardiovascular disease in type 1 diabetes

Abstract: BackgroundWe recently reported strong associations between eight skin collagen AGEs and two solubility markers from skin biopsies obtained at DCCT study closeout and the long-term progression of microvascular disease in EDIC, despite adjustment for mean glycemia. Herein we investigated the hypothesis that some of these AGEs (fluorescence to be reported elsewhere) correlate with long-term subclinical cardiovascular disease (CVD) measurements, i.e. coronary artery calcium score (CAC) at EDIC year 7–9 (n = 187), … Show more

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Cited by 52 publications
(63 citation statements)
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References 32 publications
(44 reference statements)
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“…The accumulation of compounds in the extracellular space and within the cells of vessel wall contributed to the accelerated endothelial dysfunction in diabetes . In type 1 diabetes, multiple AGEs are associated with intima‐media thickness progression in spite of adjustment for A1c implying a likely participatory role of glycation and AGE mediated cross‐linking on matrix accumulation in coronary arteries . Takeuchi et al .…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…The accumulation of compounds in the extracellular space and within the cells of vessel wall contributed to the accelerated endothelial dysfunction in diabetes . In type 1 diabetes, multiple AGEs are associated with intima‐media thickness progression in spite of adjustment for A1c implying a likely participatory role of glycation and AGE mediated cross‐linking on matrix accumulation in coronary arteries . Takeuchi et al .…”
Section: Discussionmentioning
confidence: 99%
“…[20] In type 1 diabetes, multiple AGEs are associated with intima-media thickness progression in spite of adjustment for A1c implying a likely participatory role of glycation and AGE mediated cross-linking on matrix accumulation in coronary arteries. [21] Takeuchi et al [22] believed that toxic compounds glyceraldehyde-derived AGEs (AGE-2) and glycolaldehyde derived AGEs (AGE-3) were the contributors for the damage of AGEs on endothelial dysfunction, but not all compounds. The endothelial dysfunction activity of AGE-2 and AGE-3 might be associated with the following com-pounds: trihydroxy-triosidine, triosidine-carbaldehyde, arg-hydroxy-triosidine, lys-hydroxy-triosidine, GA-pyridine, tetrahydro-pyrimidine and so on.…”
Section: 36mentioning
confidence: 99%
“…36,37 Skin collagen AGEs obtained from skin biopsies at the close of DCCT, such as glucosepane and methylglyoxal hydroimidazolone, were reported to be correlated with the progression of carotid IMT during the DCCT-EDIC even after adjustment for mean HbA1c values. 38 Furthermore, total fluorescence of collagen digests and long-wave fluorophore 1 (LW-1), a collagen-linked fluorescent product that has a lysine residue coupled to a sugar molecule, were also associated with IMT progression and left ventricular mass at Years 12 and 14-16 in the DCCT-EDIC, respectively. 39…”
Section: Diabetes Control and Complications Trial-epidemiology Of Diamentioning
confidence: 99%
“…Increases in AGE formation on skin collagen [10][11][12] and within the circulation [13,14] predict poor prognosis for patients with diabetes including increased risk for kidney and cardiovascular disease. The kidneys are a major site of AGE detoxification through the filtration of circulating AGEs and their subsequent active uptake and excretion [15,16].…”
Section: Introductionmentioning
confidence: 99%