Skin Carotenoid Level as an Alternative Marker of Serum Total Carotenoid Concentration and Vegetable Intake Correlates with Biomarkers of Circulatory Diseases and Metabolic Syndrome

Matsumoto, Mai; Suganuma, Hiroyuki; Shimizu, Sunao; Hayashi, Hiroki; Sawada, Kahori; Tokuda, Itoyo; Ihara, Kazushige; Nakaji, Shigeyuki

doi:10.3390/nu12061825

Cited by 32 publications

(30 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A relationship between blood carotenoid levels and vegetable intake was also reported by Campbell et al using a frequency survey Food Frequency Questionnaire [ 16 ]. These previous studies are consistent with ours, suggesting that serum carotenoid concentrations could be an indicator of vegetable intake and that this could be expected to be helpful for nutritional guidance according to which non-invasive measurement of skin carotenoid levels has begun to be implemented [ 29 ].…”

Section: Discussionsupporting

confidence: 88%

Association between Biomarkers of Cardiovascular Diseases and the Blood Concentration of Carotenoids among the General Population without Apparent Illness

Matsumoto¹,

Waki²,

Suganuma³

et al. 2020

Nutrients

Self Cite

View full text Add to dashboard Cite

Several studies have demonstrated that carotenoid-rich vegetables are useful against cardiovascular diseases (CVDs). However, it is still unclear when a healthy population should start eating these vegetables to prevent CVDs. In this study, we evaluated the role of carotenoids in CVD markers in healthy subjects using age-stratified analysis. We selected 1350 subjects with no history of apparent illness who were undergoing health examinations. We then evaluated the relationship between the serum concentrations of six major carotenoids as well as their total, and nine CVD markers (i.e., body mass index (BMI), pulse wave velocity (PWV), systolic blood pressure (SBP), diastolic blood pressure (DBP), Homeostatic Model Assessment of Insulin Resistance (HOMA-IR), blood insulin, fasting blood glucose (FBG), triglycerides (TGs), and high-density lipoprotein (HDL) cholesterol) using multiple regression analysis. It was found that the total carotenoid level was significantly associated with seven markers other than BMI and FBG in males and with eight markers other than DBP in females. Many of these relationships were independent of lifestyle habits. Many significant relationships were found in young males (aged 20–39) and middle-aged females (aged 40–59). These findings can be used as lifestyle guidance for disease prevention although the causal relationships should be confirmed.

show abstract

Section: Discussionsupporting

confidence: 88%

Association between Biomarkers of Cardiovascular Diseases and the Blood Concentration of Carotenoids among the General Population without Apparent Illness

Matsumoto¹,

Waki²,

Suganuma³

et al. 2020

Nutrients

Self Cite

View full text Add to dashboard Cite

show abstract

“…A cross-sectional study in a group of ethnically diverse adults in New Zealand found an inverse correlation between skin carotenoid concentrations and BMI ( 54 ). This correlation was confirmed in a sample of Japanese adults ( 55 ). Few studies have examined this association in pediatric populations.…”

Section: Discussionmentioning

confidence: 53%

Weight Status and Visceral Adiposity Mediate the Relation between Exclusive Breastfeeding Duration and Skin Carotenoids in Later Childhood

Liu

Edwards

Cannavale

et al. 2021

Current Developments in Nutrition

View full text Add to dashboard Cite

Background Breastfeeding is associated with healthier weight and nutrient status in early life. However, the impact of breastfeeding on carotenoid status beyond infancy, and the influence of adiposity, is unknown. Objective The aim of the study was to retrospectively investigate the relationship between breastfeeding and carotenoid status, and the mediating effect of weight status and adiposity on this relationship among school-aged children. Methods This was a secondary analysis of baseline data collected from a randomized-controlled clinical trial. (ClinicalTrials.gov Identifier: NCT03521349). 7–12-year-old (n = 81) children were recruited from East-Central Illinois. Dual-energy x-ray absorptiometry (DXA) was used to assess visceral adipose tissue (VAT) and whole-body adiposity (%Fat). Weight was obtained to calculated body mass index percentile (BMI %ile). Skin carotenoids were assessed via reflection spectroscopy. Macular carotenoids were assessed as macular pigment optical density (MPOD). Dietary, birth, and breastfeeding information was self-reported by parents. Results Skin carotenoids were inversely related to %Fat (P < 0.01), VAT (P < 0.01) and BMI %ile (P < 0.01). VAT and BMI %ile significantly mediated this relationship between exclusive breastfeeding duration and skin carotenoids, following adjustment for dietary carotenoids, energy intake, and mother education. Conclusions Weight status and adipose tissue distribution mediate the positive correlation between exclusive breastfeeding duration and skin carotenoids among children aged 7–12 years. The results indicate the need to support breastfeeding and healthy physical growth in childhood for optimal carotenoid status.

show abstract

“…Of the carotenoids present in the skin, β-carotene was present in the highest concentration (0.517 µg/mL). Those authors found that the levels of carotenoids in the skin were associated with a lower body mass index, blood pressure, index of insulin resistance, and triglyceride concentration, as well as an increase in HDL-c levels [ 69 ].…”

Section: Type 2 Diabetes Mellitusmentioning

confidence: 99%

β-Carotene: Preventive Role for Type 2 Diabetes Mellitus and Obesity: A Review

et al. 2020

View full text Add to dashboard Cite

Carotenoids are vital antioxidants for plants and animals. They protect cells from oxidative events and act against the inflammatory process and carcinogenesis. Among the most abundant carotenoids in human and foods is β-carotene. This carotenoid has the highest level of provitamin A activity, as it splits into two molecules of retinol through the actions of the cytosolic enzymes: β-carotene-15,15′-monooxygenase (β-carotene-15,15′-oxygenase 1) and β-carotene-9′,10′-dioxygenase (β-carotene-9′,10′-oxygenase 2). The literature supports the idea that β-carotene acts against type 2 diabetes mellitus, cardiovascular diseases, obesity, and metabolic syndrome. Due to the many processes involved in β-carotene biosynthesis and metabolic function, little is known about such components, since many mechanisms have not yet been fully elucidated. Therefore, our study concisely described the relationships between the consumption of carotenoids, with emphasis on β-carotene, and obesity and type 2 diabetes mellitus and its associated parameters in order to understand the preventive role of carotenoids better and encourage their consumption.

show abstract

Skin Carotenoid Level as an Alternative Marker of Serum Total Carotenoid Concentration and Vegetable Intake Correlates with Biomarkers of Circulatory Diseases and Metabolic Syndrome

Cited by 32 publications

References 44 publications

Association between Biomarkers of Cardiovascular Diseases and the Blood Concentration of Carotenoids among the General Population without Apparent Illness

Association between Biomarkers of Cardiovascular Diseases and the Blood Concentration of Carotenoids among the General Population without Apparent Illness

Weight Status and Visceral Adiposity Mediate the Relation between Exclusive Breastfeeding Duration and Skin Carotenoids in Later Childhood

β-Carotene: Preventive Role for Type 2 Diabetes Mellitus and Obesity: A Review

Contact Info

Product

Resources

About