Skin Care Product Rich in Antioxidants and Anti-Inflammatory Natural Compounds Reduces Itching and Inflammation in the Skin of Atopic Dermatitis Patients

Abstract

The atopic dermatitis (AD) complex pathogenesis mechanism reveals marked changes of certain signaling factors as well as some morphological alterations in the epidermis. Reduced resilience against environmental factors and oxidative stress often makes the treatment with corticosteroids or tacrolismus ointments indispensable. In view of the correlation between oxidative stress and AD pathological factors, antioxidants can be incorporated into AD management strategies. This study investigates a curly kale, apple and green tea-containing natural extract rich in antioxidants for its effects on signaling inflammatory molecules and skin barrier enhancement in human epidermal keratinocytes- (NHEKs) based cell assays. Furthermore, the skin penetration on porcine ears was measured ex vivo using Raman micro spectroscopy. Finally, in a double-blind half-side, placebo-controlled clinical study, the effects of a formulation containing this extract were analyzed for the influence of lesion severity, epidermal barrier function, and pruritus in mild to moderately AD patients. Summarizing our results: The extract reduces expression of inflammatory cytokines in keratinocytes and increases barrier-related molecules. The verum formulation with a very high antioxidant capacity used in AD patients with mild to moderate lesions reduces itching, local SCORAD, and improves barrier function and the hydration of skin lesions.

Atopic Dermatitis: Molecular Alterations between Lesional and Non-Lesional Skin Determined Noninvasively by In Vivo Confocal Raman Microspectroscopy

“…It is known that topical and/or systemic application of carotenoids results in a long-term increase in their concentration in the HS [28]. Furthermore, topical application of antioxidant and anti-inflammatory substances has recently been shown to improve clinical symptoms in AD [87]. Therefore, it might be helpful to test in the future whether topical and/or systemic application of carotenoids in AD patients will improve the SBF and clinical disease management.…”

Role of antioxidants in itch treatment: lessons learned from pain management

“…Animal studies evaluating the use of antioxidants for the treatment of AD show mixed results in their ability to reduce pruritus [46,66] . A cream containing antioxidant such as EGCG, quercetin, and the flavonoid kaempferol was shown to significantly reduce pruritus intensity after 28 days in patients with atopic dermatitis [67] . Another review analyzing the use of topical antioxidant furfuryl palmitate showed that it is useful in reducing pruritus in atopic dermatitis as well as other dermatologic conditions [68] .…”

Biopharmaceutical Investigation of Antioxidant Gel

“…З огляду на зв'язок між оксидативним стресом і патогенетичними факторами захворювань шкіри, антиоксиданти можуть бути включені в стратегії управління цими захворюваннями [8]. Однак дерматологічні лікарські форми з антиоксидантами на фармацевтичному ринку представлені недостатньо.…”