Skin Cancers in Organ Transplant Recipients: Two Cases of Virus-Induced Neoplasms

Hofbauer, Günther F.L.; Dummer, Reinhard; Hafner, Jürg; Burg, Günter; Binswanger, U; Kempf, Werner

doi:10.1159/000051683

Cited by 5 publications

(3 citation statements)

References 17 publications

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“…The HPV genome has been detected in SCC in allograft recipients [5, 6, 7]. Furthermore, transitions from viral warts to SCCs have been observed histologically [19].…”

Section: Discussionmentioning

confidence: 99%

“…Whilst the role of HPV in the development of cutaneous malignancies is controversial, this is most likely due to the oncogenic potential of a fraction of the HPVs. Several groups have detected genomic fragments of HPV in SCCs of organ allograft recipients [5, 6, 7]. Besides functional and esthetic inpairment, this is the first priority rationale behind the active treatment of recalcitrant warts in immunosuppressed patients.…”

Section: Introductionmentioning

confidence: 99%

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CO<sub>2</sub> Laser Treatment of Warts in Immunosuppressed Patients

et al. 2003

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Background: A large proportion of chronically immunosuppressed patients suffer from recalcitrant viral warts. Furthermore, the incidence of nonmelanoma skin cancer is clearly elevated in this patient group and human papillomavirus is most likely to play a causal role in these neoplasms. Objective: To analyze the effectiveness of treatment of viral warts with the CO₂ laser in immunosuppressed patients. Methods: Multiple viral warts of 13 patients with immunosuppression, a majority of them renal allograft recipients, were treated with CO₂ laser in local or regional anesthesia. In case of recurrences, the lesions were treated again after 3 months. Results: 12 of 13 patients experienced dramatic improvement after 1–3 treatment sessions, 6 of these patients showed full remission. Side effects such as postoperative pain or scarring were minimal. Conclusion: CO₂ laser treatment of recalcitrant warts in immunosuppressed patients shows promising results which are comparable to those in immunocompetent hosts. This offers a welcome enlargement of the array of therapies in this otherwise difficult-to-treat group of patients and may contribute to the reduction of risk factors for nonmelanoma skin cancer.

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“…The HPV genome has been detected in SCC in allograft recipients [5, 6, 7]. Furthermore, transitions from viral warts to SCCs have been observed histologically [19].…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

CO<sub>2</sub> Laser Treatment of Warts in Immunosuppressed Patients

et al. 2003

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“…27,28 Em estudo recente, Wilkins et al descrevem as múltiplas relações entre neoplasias cutâneas malignas e doença pelo vírus da imunodeficiência humana, reforçando as relações entre vírus, câncer e imunossupressão. Os autores afirmam que a presença do vírus é necessária, mas não suficiente, para causar a neoplasia.…”

Section: Discussionunclassified

Prevalência do herpes-vírus humano tipo 1 em neoplasias cutâneas epiteliais malignas

Ypiranga

Moraes

2009

An. Bras. Dermatol.

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Resumo: FUNDAMENTOS -O DNA viral pode atuar como oncogene, favorecendo o desenvolvimento de neoplasias, como as linfoides e da pele. Entre esses vírus, encontram-se alguns herpes-vírus humanos. OBJETIVO -Identificar a presença de DNA do herpes-vírus humano tipo 1 em neoplasias epiteliais pré-malignas, malignas e pele normal de indivíduos controle, avaliando seu papel na carcinogênese. MÉTODOS -Identificação, por reação em cadeia da polimerase, do DNA viral do tumor e pele sã de 41 pacientes e comparação com grupo controle, sem neoplasia. Análise estatística: Testes de Fisher e de McNemar. RESULTADOS -O vírus foi identificado em 20 indivíduos sem e em 21 com neoplasia. Destes últimos, 11 o expessaram apenas nas células tumorais. A diferença, entretanto, não foi estatisticamente significante. CONCLUSÕES -Parece não haver relação direta entre o encontro do DNA viral na pele sã e na pele tumoral. Sua presença pode facilitar o desenvolvimento da neoplasia ou apenas coincidir de se localizar onde esta já ocorreu. Palavras-chave: Herpes-vírus humano 1; Neoplasias cutâneas; Reação em cadeia de polimerase; Vírus oncogênicos Abstract: Background -Viral DNA may act as an oncogene, especially in skin and lymphoid organs. This group includes some human herpes virus. Objective -To identify human herpes virus type 1 DNA in pre-malignant and malignant skin samples of epithelial tumors comparing to normal skin to determine its role in carcinogenesis. Methods -Forty-one patients with epithelial tumors were submitted to biopsies from tumor and normal skin. The control group comprised 41 biopsies from patients with other dermatoses than cancer. After DNA extraction, polymerase chain reaction was performed to identify 199-bp band. The results were statistically evaluated by Fisher and McNemar tests. Results -The virus was identified in 20 subjects without cancer and in 21 with skin cancer. From these, 11 expressed it only in tumor cells. This difference was not significant. Conclusion -There seem to be no direct relation between viral findings in normal skin and skin cancer cells. It may act as a promoter or just coexist at the same site where a neoplastic transformation has already occurred.

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Leitlinie: Analrandkarzinom (Entwicklungsstufe S1, IDA: -)

Wienert

2004

coloproctology

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Zur Erstellung nachfolgender Leitlinie wurde die derzeit vorliegende Literatur systematisch recherchiert. Sie wurde anhand des Erkenntnismaterials verfasst und anschließend in drei jeweils mehrtägigen Konsensuskonferenzen diskutiert und ver abschiedet. Definition ICD 10: C44.5Das Analrandkarzinom (Plattenepithelkarzinom, Spinaliom, Stachelzellkarzinom) ist ein lokal infiltrierender, destruierend wachsender maligner Hauttumor, der sich auf dem Boden einer Analen Intraepithelialen Neoplasie (AIN) entwickelt und eher selten manifestiert. EpidemiologieDas Plattenepithelkarzinom, zweithäufigster maligner Tumor der lichtexponierten Haut, kommt im Analbereich selten vor. Brown et al. sahen in einem Zeitraum von 25 Jahren insgesamt 42 perianale Tumoren bei 26 Frauen und 16 Männern mit einem Durchschnittsalter von 56 Jahren. ÄtiopathogeneseDas Tumorwachstum beginnt in der Regel nicht de novo; es entsteht meist auf vorgeschädigter Haut, wie beispielsweise bei Kondylombefall [1,4,11,13,14,20], bei Lichen ruber planus [5], Acne inversa [7, 12, 15, 19], Morbus Crohn [10, 16] und Lichen sclerosus et atrophicans [3, 17, 18]. Eine Immunsuppression begünstigt die Tumorentstehung [6, 9]. Klinischer Befund Die AIN stellt sich als uncharakteristische ekzemartige Hautveränderung dar. Das eigentliche Analrandkarzinom manifestiert sich als derber, manchmal glatter, meist jedoch verruköser haut farbener bis rötlicher Knoten. Es wächst im Laufe von Monaten und Jahren peripher und in die Tiefe und zerfällt dann geschwürig. Bei Exulzeration haben die Patienten zunehmend Beschwerden. Sie klagen über Jucken, Nässen, Blutung und Schmerzen. Ohne Therapie infiltriert der Tumor in tiefere Gewebsstrukturen und metastasiert schließlich in die regionären Lymphknoten. Fernmetastasen treten nur selten auf. Bezüg-lich der Letalität finden sich in der Literatur keine aussagekräftigen Angaben. Die Prognose hängt von den Faktoren Tumorgröße, Primär-oder Rezidivtumor, Ausbrei tungs stadium, histologische Differenzierung und Immunstatus ab. Diagnostik Mittels Inspektion und Palpation wird die Verdachtsdiagnose gestellt, die histologisch gesichert wird. Es sollte die Dicke des Tumors bestimmt werden (sog. Microstaging). Der histomorpho logische Differenzierungsgrad (Grading) wird nach Broders in gut, mä-coloproctology coloproctology

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Skin Cancers in Organ Transplant Recipients: Two Cases of Virus-Induced Neoplasms

Cited by 5 publications

References 17 publications

CO<sub>2</sub> Laser Treatment of Warts in Immunosuppressed Patients

CO<sub>2</sub> Laser Treatment of Warts in Immunosuppressed Patients

Prevalência do herpes-vírus humano tipo 1 em neoplasias cutâneas epiteliais malignas

Leitlinie: Analrandkarzinom (Entwicklungsstufe S1, IDA: -)

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