Skin Cancer Risk Among Solid Organ Recipients: A Nationwide Cohort Study in Denmark

Jensen, Annette Østergaard; Sværke, Claus; Farkas, Dóra Körmendiné; Pedersen, Lars; Kragballe, Knud; Sørensen, Henrik Toft

doi:10.2340/00015555-0919

Cited by 104 publications

(97 citation statements)

References 24 publications

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“…There is, however, no conclusive evidence regarding the causal role of HPV in actinic keratosis at this time. Additional evidence for the role of HPV comes from a study on post-transplant SCC that occurred in a cohort of 500 recipients of allografts; HPV DNA could be detected in nearly 50% of all SCCs (21)(22)(23).…”

Section: Discussionmentioning

confidence: 99%

Long-Term Risk of Cancer in Survivors of Pediatric ESRD

Amstel

Vogelzang

Starink

et al. 2015

Clinical Journal of the American Society of Nephrology

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Background and objectives ESRD is associated with an increased risk of malignancies. We analyzed the incidence of cancer in patients with pediatric ESRD after long-term follow-up.Design, setting, participants, & measurements All Dutch patients born before 1979 who were transplanted at age ,15 years old in 1972-1992 were followed until 2010. We explored type and incidence of malignancies in patients compared with the general population using the National Cancer Registry.Results After a median of 25.3 years (1.3-37.8) of transplantation and at a median age of 33.5 years old (11.0-49.0), 105 primary malignancies had occurred in 54 of 249 patients. Among them, cutaneous squamous cell carcinoma was most frequent. Patients ages 25-30 years old had developed 16.5 times (95% confidence interval, 7.9 to 34.6) as many de novo tumors and 991 times (95% confidence interval, 313 to 3137) as many de novo cutaneous squamous cell carcinomas as their general population counterparts; in survivors ages 45-50 years old, these numbers were 81.5 (95% confidence interval, 50.7 to 131.1) and 2610 (95% confidence interval, 1596 to 4267), respectively. Cumulative incidence competing risk analysis showed that, after 30 years of transplantation, 41% of the survivors had developed cancer; 31% had developed a second de novo cancer ,1 year after initial cancer diagnosis.Conclusions Cancer is highly prevalent among patients with pediatric ESRD after 25.3 years of transplantation, with a high rate of recurrence.

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Section: Discussionmentioning

confidence: 99%

Long-Term Risk of Cancer in Survivors of Pediatric ESRD

Amstel

Vogelzang

Starink

et al. 2015

Clinical Journal of the American Society of Nephrology

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“…Jensen et al reported an SIR of 5.6 for BCC and 113 for SCC (ref. 7 ). In our study it was not possible to calculate adjusted risk for different types of NMSC, as data in the external group do not specify the exact type of NMSC.The relatively low incidence of skin cancer in a cohort of HTRs was recorded by Rinaldiet al or Park et al in a single centre in Korea 8,9 .…”

Section: Discussionmentioning

confidence: 99%

Significantly higher incidence of skin cancer than other malignancies in patients after heart transplantation. A retrospective cohort study in the Czech Republic

Sečníková¹,

Göpfertová²,

Hošková³

et al. 2015

BIOMED PAP

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Aims.To perform the first study in Czech Republic on heart transplant recipients (HTRs), compare the risks for different types of cancer and provide comprehensive analysis of skin cancer and other types of cancer morbidity from which we would be able to derive an evidence-based skin cancer surveillance program. Materials and Methods. A retrospective cohort study was performed to determine and compare standardized morbidity ratio (SMR) of different types of cancer developed after heart transplantation. We analysed data obtained from medical documentation of 603 HTRs transplanted between 1993 and 2010. Results. 191 incident cases of malignancy occurred in123 HTRs (20.4%). According to expectations, nonmelanoma skin cancer was the most frequent type of malignancy (119 cases) with SMR 7.6 (P < 0.001), followed by lung cancer with SMR 2.7 (P < 0.001). SMR for melanoma was 2.5, P = 0.129. Other types of cancer in HTRs (prostate and kidney cancer) were less frequent (SMR 2.06, P = 0.038 and SMR 2.03, P = 0.122). Conclusion. The risk of malignancy development is significantly higher for HTRs compared to the general population. Squamous cell carcinoma of the skin is the most frequent type of cancer followed by basal cell carcinoma. These findings emphasise the importance of regular skin cancer screening in HTRs.

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“…[27][28][29][30][31][32] Immunosuppressive drugs were a specific exclusion from this study because the increased risks of skin cancer for patients on long-term immunosuppression are profound. 33,34 To reveal a potential role of dietary furanocoumarins and antioxidants, we included a short dietary section in the questionnaire asking participants to report if they regularly (three or more times per week) took any of the following foods known to contain furanocoumarins: celery, celeriac, parsnips, lemons ⁄limes and carrots. 35 Likewise, consumption of antioxidant-rich food items like figs, tomatoes, red grapes ⁄red wine, blackcurrants or other red berries, pomegranate, green tea, soyabeans or antioxidant supplements was assessed.…”

Section: Questionnairementioning

confidence: 99%

Known and potential new risk factors for skin cancer in European populations: a multicentre case-control study

Vries

Trakatelli

Kalabalikis

et al. 2012

British Journal of Dermatology

140

111

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BACKGROUND: \ud \ud During recent years numerous studies have suggested that personal and environmental factors might influence cancer development.\ud \ud OBJECTIVES: \ud \ud To investigate environmental and personal characteristics associated with skin cancer risk.\ud \ud METHODS: \ud \ud A multicentre hospital-based case-control study was performed in Finland, Germany, Greece, Italy, Malta, Poland, Scotland and Spain, including 409 patients with squamous cell carcinoma (SCC), 602 with basal cell carcinoma (BCC) and 360 with cutaneous malignant melanoma (CMM) and 1550 control persons. Exposures were assessed by questionnaires that were partly self-administered, partly completed by dermatologists. Unconditional logistic regression modelling was used to assess associations including the influence of certain drugs and food items on skin cancer risk.\ud \ud RESULTS: \ud \ud The usual associations were observed for sun exposure and pigmentation characteristics, with chronic sun exposure being most strongly associated with SCC risk, and naevi and atypical naevi with CMM risk. Use of ciprofloxacin was associated with a decreased risk of BCC [odds ratio (OR) 0·33] and use of thiazide diuretics was associated with an increased risk of SCC (OR 1·66). Ciprofloxacin was also associated with SCC (OR 0·34) and thiazines with BCC (OR 2·04), but these associations lost significance after correction for multiple testing. Consumption of pomegranate, rich in antioxidants, was associated with decreased BCC and SCC risk, also after correcting for multiple testing. Recent experience of stressful events was associated with increased risk, particularly of CMM.\ud \ud CONCLUSIONS: \ud \ud In this large case-control study from across Europe the expected associations were observed for known risk factors. Some new potential protective factors and potential risk factors were identified for consumption of certain food items, medication use and stress, which deserve further investigation in future studies

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Skin Cancer Risk Among Solid Organ Recipients: A Nationwide Cohort Study in Denmark

Cited by 104 publications

References 24 publications

Long-Term Risk of Cancer in Survivors of Pediatric ESRD

Long-Term Risk of Cancer in Survivors of Pediatric ESRD

Significantly higher incidence of skin cancer than other malignancies in patients after heart transplantation. A retrospective cohort study in the Czech Republic

Known and potential new risk factors for skin cancer in European populations: a multicentre case-control study

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