Skin Cancer

Abstract

Skin cancer is the most common form of human cancer and causes significant morbidity and mortality. A wide variety of techniques have been used to model skin cancer in mice, including genetically engineered mice, exposure to chemical carcinogens or ultraviolet light, and xenograft studies of human skin and human skin reconstructs. These models have been used to validate human cancer genetics, identify new oncogenes and tumor suppressors, and to develop novel therapies for use in human skin cancer.