Skin cancer prevention – Recent advances and unmet challenges

Mortaja, Mahsa; Demehri, Shadmehr

doi:10.1016/j.canlet.2023.216406

Cited by 5 publications

(2 citation statements)

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“…The UV spectrum of sunlight is one of the most important exogenous factors (component of the exposome) in the development of skin cancer. This is supported by the observation that non‐melanoma skin tumours such as basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) occur on Caucasian race mainly in areas regularly exposed to sunlight 1,2 . Annual total UV radiation depends primarily on geographical location, as UV radiation increases as one approaches the equator 3–5 .…”

Section: Introductionmentioning

confidence: 92%

“…All these factors contribute to the development of skin tumours. The immunosuppressive drugs significantly reduce the skin's ability to protect itself from the carcinogenic effects of UV light, indirectly by reducing certain immune functions and directly by sensitising keratinocytes to the DNA‐damaging effects of UV light 1,2,6,9–15 . Therefore skin tumours in OTRs usually have a multiplex appearance, behave aggressively and are prone to recurrence 9 …”

Section: Introductionmentioning

confidence: 99%

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Effect of education on sun‐safe behaviour in kidney transplant recipients

Tári,

Janka,

Emri

et al. 2024

Photoderm Photoimm Photomed

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BackgroundOrgan transplant recipients (OTR) are more likely to develop skin cancer than the general population. One of the main components of the exposome that triggers the development of skin tumours is solar ultraviolet (UV) radiation. To reduce the incidence of harmful consequences of sun exposure, sun protection education is needed for patients taking long‐term immunosuppressive drugs.MethodsIn a previous study, we assessed the sun‐safe behaviour of 221 OTR using a questionnaire before and after transplantation and personally educated the patients about proper sun protection. After the education, there were no further reminder presentations. Presently, the sun protection and sun seeking habits of the available 176 of these patients were questioned to assess the long‐term effect of the previous sun protection education.ResultsTwo‐four years after the education, more patients wore hats and protected their skin with long‐sleeved clothing than before the education. In terms of sun seeking habits, both occupational and recreational sun exposure decreased significantly. Significantly fewer people went on holiday after transplantation, but those who went on holiday spent significantly less time in the sun.ConclusionThe long‐term positive effects of education can be seen both in the patients' sun protection and in their sun seeking habits. However, the long‐term goal is to maintain these results and thereby reduce the likelihood of skin tumours and consequently the associated tumour death.

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Section: Introductionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%