Skin cancer, photoprotection, and skin of color

Dadzie, Ophelia E.; Jablonski, Nina G.; Mahalingam, Meera; Dupuy, Alain; Petit, Antoine

doi:10.1016/j.jaad.2014.04.071

Cited by 7 publications

(4 citation statements)

References 2 publications

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“…Agbai et al were also uncertain about the role of sunscreen in the prevention of CM in PADs 31 . Dadzie et al find unrealistic the recommendation of routine use of sunscreen in PADs living in sub‐Saharan Africa especially as sun exposure is not proven to be contributory to CM in these individuals unlike their Caucasian counterparts 53 . So, in PADs, regular skin examination specifically of the feet especially if there is a history of trauma or atypical nevi should be encouraged.…”

Section: Prevention Practicesmentioning

confidence: 99%

“…31 Dadzie et al find unrealistic the recommendation of routine use of sunscreen in PADs living in sub-Saharan Africa especially as sun exposure is not proven to be contributory to CM in these individuals unlike their Caucasian counterparts. 53 So, in PADs, regular skin examination specifically of the feet especially if there is a history of trauma or atypical nevi should be encouraged. Worrisome in PAD, is the practice of sun exposure to increase serum Vitamin D, a practice which could potentially increase the risk of CM in these individuals.…”

Section: Prevention Practicesmentioning

confidence: 99%

See 1 more Smart Citation

Comparative study of cutaneous melanoma and its associated issues between people of African decent and Caucasians

Anaba

2021

Dermatologic Therapy

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Cutaneous melanoma is uncommon in people of African descent unlike their Caucasian counterparts. This rarity of cutaneous melanoma in people of African descent makes studies in this group difficult. In the few studies that are available, several differences exist in the incidence, disease severity, course of the disease, treatment modalities and survival rates between these two groups. Observed difference in cutaneous melanoma between people of African descent and Caucasians include; a higher incidence and better prognosis in Caucasians, a low awareness of melanoma, no definite risk factors, presentation with advanced disease, poor melanoma specific survival in people of African descent. Other differences are a better UV-induced DNA damage recovery, acral as opposed to truncal melanoma, female preponderance and lack of preventive measures in people of African descent.

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Section: Prevention Practicesmentioning

confidence: 99%

Section: Prevention Practicesmentioning

confidence: 99%

Comparative study of cutaneous melanoma and its associated issues between people of African decent and Caucasians

Anaba

2021

Dermatologic Therapy

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“…Skin color, a well-established heritable trait, is highly influenced by environmental and endocrine factors [1, 2]. Upregulation of melanin in specialized melanin-producing cells is most often observed in response to environmental stresses and has been established to provide protection against UV-induced DNA damage [3].…”

Section: Introductionmentioning

confidence: 99%

Modulation of Diacylglycerol-Induced Melanogenesis in Human Melanoma and Primary Melanocytes: Role of Stress Chaperone Mortalin

Wadhwa

Singh

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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Skin color/pigmentation is regulated through melanogenesis process in specialized melanin-producing cells, melanocytes, involving multiple signaling pathways. It is highly influenced by intrinsic and extrinsic factors such as oxidative, ultraviolet radiations and other environmental stress conditions. Besides determining the color, it governs response and tolerance of skin to a variety of environmental stresses and pathological conditions including photodamage, hyperpigmentation, and skin cancer. Depigmenting reagents have been deemed useful not only for cosmetics but also for pigmentation-related pathologies. In the present study, we attempted modulation of 1-oleoyl-2-acetyl-glycerol- (OAG-) induced melanogenesis in human melanoma and primary melanocytes. In both cell types, OAG-induced melanogenesis was associated with increase in enhanced expression of melanin, tyrosinase, as well as stress chaperones (mortalin and HSP60) and Reactive Oxygen Species (ROS). Treatment with TXC (trans-4-(Aminomethyl) cyclohexanecarboxylic acid hexadecyl ester hydrochloride) and 5/40 natural compounds resulted in their reduction. The data proposed an important role of mortalin and oxidative stress in skin pigmentation and the use of TXC and natural extracts for modulation of pigmentation pathways in normal and pathological conditions.

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“…Quel paradoxe d'émettre des recommandations destinées à une population qu'on ne peut pas définir et qu'on ne souhaite pas cibler ! De cet étrange tissu de contradictions émerge la plus inquiétante des craintes, que nous avons soulevée dans une lettre aux auteurs [7], qui serait l'hypothèse d'un conflit d'intérêts entre les institutions dermatologiques et l'industrie des cosmétiques antisolaires. Les recommandations officielles de l'AAD ayant une portée internationale, elles sont susceptibles de soutenir la promotion des antisolaires dans toutes les régions du monde, là où personne n'imagine que de tels produits puissent avoir le moindre intérêt pour la santé des populations -mais où les populations elles-mêmes pourraient, pour différentes raisons, être sensibles à cette promotion.…”

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